Translating non-invasive signals such as photoplethysmography (PPG) and ballistocardiography (BCG) into clinically meaningful signals like arterial blood pressure (ABP) is vital for continuous, low-cost healthcare monitoring. However, temporal misalignment in multimodal signal transformation impairs transformation accuracy, especially in capturing critical features like ABP peaks. Conventional synchronization methods often rely on strong similarity assumptions or manual tuning, while existing Learning with Noisy Labels (LNL) approaches are ineffective under time-shifted supervision, either discarding excessive data or failing to correct label shifts. To address this challenge, we propose ShiftSyncNet, a meta-learning-based bi-level optimization framework that automatically mitigates performance degradation due to time misalignment. It comprises a transformation network (TransNet) and a time-shift correction network (SyncNet), where SyncNet learns time offsets between training pairs and applies Fourier phase shifts to align supervision signals. Experiments on one real-world industrial dataset and two public datasets show that ShiftSyncNet outperforms strong baselines by 9.4%, 6.0%, and 12.8%, respectively. The results highlight its effectiveness in correcting time shifts, improving label quality, and enhancing transformation accuracy across diverse misalignment scenarios, pointing toward a unified direction for addressing temporal inconsistencies in multimodal physiological transformation.

Arterial blood pressure (ABP) holds substantial promise for proactive cardiovascular health management. Notwithstanding its potential, the invasive nature of ABP measurements confines their utility primarily to clinical environments, limiting their applicability for continuous monitoring beyond medical facilities. The conversion of photoplethysmography (PPG) signals into ABP equivalents has garnered significant attention due to its potential in revolutionizing cardiovascular disease management. Recent strides in PPG-to-ABP prediction encompass the integration of generative and discriminative models. Despite these advances, the efficacy of these models is curtailed by the latent space shift predicament, stemming from alterations in PPG data distribution across disparate hardware and individuals, potentially leading to distorted ABP waveforms. To tackle this problem, we present an innovative solution named the Latent Space Constraint Transformer (LSCT), leveraging a quantized codebook to yield robust latent spaces by employing multiple discretizing bases. To facilitate improved reconstruction, the Correlation-boosted Attention Module (CAM) is introduced to systematically query pertinent bases on a global scale. Furthermore, to enhance expressive capacity, we propose the Multi-Spectrum Enhancement Knowledge (MSEK), which fosters local information flow within the channels of latent code and provides additional embedding for reconstruction. Through comprehensive experimentation on both publicly available datasets and a private downstream task dataset, the proposed approach demonstrates noteworthy performance enhancements compared to existing methods. Extensive ablation studies further substantiate the effectiveness of each introduced module.

Robust and reliable semantic segmentation in complex scenes is crucial for many real-life applications such as autonomous safe driving and nighttime rescue. In most approaches, it is typical to make use of RGB images as input. They however work well only in preferred weather conditions; when facing adverse conditions such as rainy, overexposure, or low-light, they often fail to deliver satisfactory results. This has led to the recent investigation into multispectral semantic segmentation, where RGB and thermal infrared (RGBT) images are both utilized as input. This gives rise to significantly more robust segmentation of image objects in complex scenes and under adverse conditions. Nevertheless, the present focus in single RGBT image input restricts existing methods from well addressing dynamic real-world scenes. Motivated by the above observations, in this paper, we set out to address a relatively new task of semantic segmentation of multispectral video input, which we refer to as Multispectral Video Semantic Segmentation, or MVSS in short. An in-house MVSeg dataset is thus curated, consisting of 738 calibrated RGB and thermal videos, accompanied by 3,545 fine-grained pixel-level semantic annotations of 26 categories. Our dataset contains a wide range of challenging urban scenes in both daytime and nighttime. Moreover, we propose an effective MVSS baseline, dubbed MVNet, which is to our knowledge the first model to jointly learn semantic representations from multispectral and temporal contexts. Comprehensive experiments are conducted using various semantic segmentation models on the MVSeg dataset. Empirically, the engagement of multispectral video input is shown to lead to significant improvement in semantic segmentation; the effectiveness of our MVNet baseline has also been verified.

Growing interests in multispectral semantic segmentation (MSS) have been witnessed in recent years, thanks to the unique advantages of combining RGB and thermal infrared images to tackle challenging scenarios with adverse conditions. However, unlike traditional RGB-only semantic segmentation, the lack of a large-scale MSS dataset has become a hindrance to the progress of this field. To address this issue, we introduce a SemanticRT dataset - the largest MSS dataset to date, comprising 11,371 high-quality, pixel-level annotated RGB-thermal image pairs. It is 7 times larger than the existing MFNet dataset, and covers a wide variety of challenging scenarios in adverse lighting conditions such as low-light and pitch black. Further, a novel Explicit Complement Modeling (ECM) framework is developed to extract modality-specific information, which is propagated through a robust cross-modal feature encoding and fusion process. Extensive experiments demonstrate the advantages of our approach and dataset over the existing counterparts. Our new dataset may also facilitate further development and evaluation of existing and new MSS algorithms.

Adversarial-based adaptation has dominated the area of domain adaptive detection over the past few years. Despite their general efficacy for various tasks, the learned representations may not capture the intrinsic topological structures of the whole images and thus are vulnerable to distributional shifts especially in real-world applications, such as geometric distortions across imaging devices in medical images. In this case, forcefully matching data distributions across domains cannot ensure precise knowledge transfer and are prone to result in the negative transfer. In this paper, we explore the problem of domain adaptive lesion detection from the perspective of relational reasoning, and propose a Graph-Structured Knowledge Transfer (GraphSKT) framework to perform hierarchical reasoning by modeling both the intra- and inter-domain topological structures. To be specific, we utilize cross-domain correspondence to mine meaningful foreground regions for representing graph nodes and explicitly endow each node with contextual information. Then, the intra- and inter-domain graphs are built on the top of instance-level features to achieve a high-level understanding of the lesion and whole medical image, and transfer the structured knowledge from source to target domains. The contextual and semantic information is propagated through graph nodes methodically, enhancing the expressive power of learned features for the lesion detection tasks. Extensive experiments on two types of challenging datasets demonstrate that the proposed GraphSKT significantly outperforms the state-of-the-art approaches for detection of polyps in colonoscopy images and of mass in mammographic images.

Due to the lack of expertise for medical image annotation, the investigation of label-efficient methodology for medical image segmentation becomes a heated topic. Recent progresses focus on the efficient utilization of weak annotations together with few strongly-annotated labels so as to achieve comparable segmentation performance in many unprofessional scenarios. However, these approaches only concentrate on the supervision inconsistency between strongly- and weakly-annotated instances but ignore the instance inconsistency inside the weakly-annotated instances, which inevitably leads to performance degradation. To address this problem, we propose a novel label-efficient hybrid-supervised framework, which considers each weakly-annotated instance individually and learns its weight guided by the gradient direction of the strongly-annotated instances, so that the high-quality prior in the strongly-annotated instances is better exploited and the weakly-annotated instances are depicted more precisely. Specially, our designed dynamic instance indicator (DII) realizes the above objectives, and is adapted to our dynamic co-regularization (DCR) framework further to alleviate the erroneous accumulation from distortions of weak annotations. Extensive experiments on two hybrid-supervised medical segmentation datasets demonstrate that with only 10% strong labels, the proposed framework can leverage the weak labels efficiently and achieve competitive performance against the 100% strong-label supervised scenario.

Due to the lack of properly annotated medical data, exploring the generalization capability of the deep model is becoming a public concern. Zero-shot learning (ZSL) has emerged in recent years to equip the deep model with the ability to recognize unseen classes. However, existing studies mainly focus on natural images, which utilize linguistic models to extract auxiliary information for ZSL. It is impractical to apply the natural image ZSL solutions directly to medical images, since the medical terminology is very domain-specific, and it is not easy to acquire linguistic models for the medical terminology. In this work, we propose a new paradigm of ZSL specifically for medical images utilizing cross-modality information. We make three main contributions with the proposed paradigm. First, we extract the prior knowledge about the segmentation targets, called relation prototypes, from the prior model and then propose a cross-modality adaptation module to inherit the prototypes to the zero-shot model. Second, we propose a relation prototype awareness module to make the zero-shot model aware of information contained in the prototypes. Last but not least, we develop an inheritance attention module to recalibrate the relation prototypes to enhance the inheritance process. The proposed framework is evaluated on two public cross-modality datasets including a cardiac dataset and an abdominal dataset. Extensive experiments show that the proposed framework significantly outperforms the state of the arts.

In medical image analysis, it is typical to collect multiple annotations, each from a different clinical expert or rater, in the expectation that possible diagnostic errors could be mitigated. Meanwhile, from the computer vision practitioner viewpoint, it has been a common practice to adopt the ground-truth labels obtained via either the majority-vote or simply one annotation from a preferred rater. This process, however, tends to overlook the rich information of agreement or disagreement ingrained in the raw multi-rater annotations. To address this issue, we propose to explicitly model the multi-rater (dis-)agreement, dubbed MRNet, which has two main contributions. First, an expertise-aware inferring module or EIM is devised to embed the expertise level of individual raters as prior knowledge, to form high-level semantic features. Second, our approach is capable of reconstructing multi-rater gradings from coarse predictions, with the multi-rater (dis-)agreement cues being further exploited to improve the segmentation performance. To our knowledge, our work is the first in producing calibrated predictions under different expertise levels for medical image segmentation. Extensive empirical experiments are conducted across five medical segmentation tasks of diverse imaging modalities. In these experiments, superior performance of our MRNet is observed comparing to the state-of-the-arts, indicating the effectiveness and applicability of our MRNet toward a wide range of medical segmentation tasks. Source code is publicly available.

Unsupervised domain adaption has proven to be an effective approach for alleviating the intensive workload of manual annotation by aligning the synthetic source-domain data and the real-world target-domain samples. Unfortunately, mapping the target-domain distribution to the source-domain unconditionally may distort the essential structural information of the target-domain data. To this end, we firstly propose to introduce a novel multi-anchor based active learning strategy to assist domain adaptation regarding the semantic segmentation task. By innovatively adopting multiple anchors instead of a single centroid, the source domain can be better characterized as a multimodal distribution, thus more representative and complimentary samples are selected from the target domain. With little workload to manually annotate these active samples, the distortion of the target-domain distribution can be effectively alleviated, resulting in a large performance gain. The multi-anchor strategy is additionally employed to model the target-distribution. By regularizing the latent representation of the target samples compact around multiple anchors through a novel soft alignment loss, more precise segmentation can be achieved. Extensive experiments are conducted on public datasets to demonstrate that the proposed approach outperforms state-of-the-art methods significantly, along with thorough ablation study to verify the effectiveness of each component. The code will be released soon at https://github.com/munanning/MADA.

Knowledge of whole heart anatomy is a prerequisite for many clinical applications. Whole heart segmentation (WHS), which delineates substructures of the heart, can be very valuable for modeling and analysis of the anatomy and functions of the heart. However, automating this segmentation can be challenging due to the large variation of the heart shape, and different image qualities of the clinical data. To achieve this goal, an initial set of training data is generally needed for constructing priors or for training. Furthermore, it is difficult to perform comparisons between different methods, largely due to differences in the datasets and evaluation metrics used. This manuscript presents the methodologies and evaluation results for the WHS algorithms selected from the submissions to the Multi-Modality Whole Heart Segmentation (MM-WHS) challenge, in conjunction with MICCAI 2017. The challenge provided 120 three-dimensional cardiac images covering the whole heart, including 60 CT and 60 MRI volumes, all acquired in clinical environments with manual delineation. Ten algorithms for CT data and eleven algorithms for MRI data, submitted from twelve groups, have been evaluated. The results showed that the performance of CT WHS was generally better than that of MRI WHS. The segmentation of the substructures for different categories of patients could present different levels of challenge due to the difference in imaging and variations of heart shapes. The deep learning (DL)-based methods demonstrated great potential, though several of them reported poor results in the blinded evaluation. Their performance could vary greatly across different network structures and training strategies. The conventional algorithms, mainly based on multi-atlas segmentation, demonstrated good performance, though the accuracy and computational efficiency could be limited. The challenge, including provision of the annotated training data and the blinded evaluation for submitted algorithms on the test data, continues as an ongoing benchmarking resource via its homepage (www.sdspeople.fudan.edu.cn/zhuangxiahai/0/mmwhs/).

Volumetric ultrasound is rapidly emerging as a viable imaging modality for routine prenatal examinations. Biometrics obtained from the volumetric segmentation shed light on the reformation of precise maternal and fetal health monitoring. However, the poor image quality, low contrast, boundary ambiguity, and complex anatomy shapes conspire toward a great lack of efficient tools for the segmentation. It makes 3-D ultrasound difficult to interpret and hinders the widespread of 3-D ultrasound in obstetrics. In this paper, we are looking at the problem of semantic segmentation in prenatal ultrasound volumes. Our contribution is threefold: 1) we propose the first and fully automatic framework to simultaneously segment multiple anatomical structures with intensive clinical interest, including fetus, gestational sac, and placenta, which remains a rarely studied and arduous challenge; 2) we propose a composite architecture for dense labeling, in which a customized 3-D fully convolutional network explores spatial intensity concurrency for initial labeling, while a multi-directional recurrent neural network (RNN) encodes spatial sequentiality to combat boundary ambiguity for significant refinement; and 3) we introduce a hierarchical deep supervision mechanism to boost the information flow within RNN and fit the latent sequence hierarchy in fine scales, and further improve the segmentation results. Extensively verified on in-house large data sets, our method illustrates a superior segmentation performance, decent agreements with expert measurements and high reproducibilities against scanning variations, and thus is promising in advancing the prenatal ultrasound examinations.