An algorithm of power control in two-tier heterogeneous networks is proposed in this paper. We consider femtocell base stations (FBSs) dense deployment in the macrocell base station (MBS) coverage, the MBS dynamically estimates total uplink interference of femtocell user equipments (FUEs). In order to cope with interference issues, the MBS decides the transmit power of macrocell user equipment (MUE) according to the uplink power budget. In the meanwhile, the interference pricing mechanism is introduced. We assume that the MBS protects itself by pricing the interference on each FUEs, so as to achieve the goal of controlling the interference from FUEs. Simulation results show that the proposed algorithm yields a significant performance improvement in terms of the channel capacity.