We introduce a comprehensive framework for modeling single cell transcriptomic responses to perturbations, aimed at standardizing benchmarking in this rapidly evolving field. Our approach includes a modular and user-friendly model development and evaluation platform, a collection of diverse perturbational datasets, and a set of metrics designed to fairly compare models and dissect their performance. Through extensive evaluation of both published and baseline models across diverse datasets, we highlight the limitations of widely used models, such as mode collapse. We also demonstrate the importance of rank metrics which complement traditional model fit measures, such as RMSE, for validating model effectiveness. Notably, our results show that while no single model architecture clearly outperforms others, simpler architectures are generally competitive and scale well with larger datasets. Overall, this benchmarking exercise sets new standards for model evaluation, supports robust model development, and furthers the use of these models to simulate genetic and chemical screens for therapeutic discovery.

In this paper we present the first safe system for full control of self-driving vehicles trained from human demonstrations and deployed in challenging, real-world, urban environments. Current industry-standard solutions use rule-based systems for planning. Although they perform reasonably well in common scenarios, the engineering complexity renders this approach incompatible with human-level performance. On the other hand, the performance of machine-learned (ML) planning solutions can be improved by simply adding more exemplar data. However, ML methods cannot offer safety guarantees and sometimes behave unpredictably. To combat this, our approach uses a simple yet effective rule-based fallback layer that performs sanity checks on an ML planner's decisions (e.g. avoiding collision, assuring physical feasibility). This allows us to leverage ML to handle complex situations while still assuring the safety, reducing ML planner-only collisions by 95%. We train our ML planner on 300 hours of expert driving demonstrations using imitation learning and deploy it along with the fallback layer in downtown San Francisco, where it takes complete control of a real vehicle and navigates a wide variety of challenging urban driving scenarios.

In this work we present a simple end-to-end trainable machine learning system capable of realistically simulating driving experiences. This can be used for verification of self-driving system performance without relying on expensive and time-consuming road testing. In particular, we frame the simulation problem as a Markov Process, leveraging deep neural networks to model both state distribution and transition function. These are trainable directly from the existing raw observations without the need of any handcrafting in the form of plant or kinematic models. All that is needed is a dataset of historical traffic episodes. Our formulation allows the system to construct never seen scenes that unfold realistically reacting to the self-driving car’s behaviour. We train our system directly from 1,000 hours of driving logs and measure both realism, reactivity of the simulation as the two key properties of the simulation. At the same time we apply the method to evaluate performance of a recently proposed state-of-the-art ML planning system [1] trained from human driving logs. We discover this planning system is prone to previously unreported causal confusion issues that are difficult to test by non-reactive simulation. To the best of our knowledge, this is the first work that directly merges highly realistic data-driven simulations with a closed loop evaluation for self-driving vehicles. We make the data, code, and pre-trained models publicly available to further stimulate simulation development.

We investigate what grade of sensor data is required for training an imitation-learning-based AV planner on human expert demonstration. Machine-learned planners [1] are very hungry for training data, which is usually collected using vehicles equipped with the same sensors used for autonomous operation [1]. This is costly and non-scalable. If cheaper sensors could be used for collection instead, data availability would go up, which is crucial in a field where data volume requirements are large and availability is small. We present experiments using up to 1000 hours worth of expert demonstration and find that training with 10x lower-quality data outperforms 1x AV-grade data in terms of planner performance (see Fig. 1). The important implication of this is that cheaper sensors can indeed be used. This serves to improve data access and democratize the field of imitation-based motion planning. Alongside this, we perform a sensitivity analysis of planner performance as a function of perception range, field-of-view, accuracy, and data volume, and reason about why lower-quality data still provide good planning results.

We use reinforcement learning in simulation to obtain a driving system controlling a full-size real-world vehicle. The driving policy takes RGB images from a single camera and their semantic segmentation as input. We use mostly synthetic data, with labelled real-world data appearing only in the training of the segmentation network.Using reinforcement learning in simulation and synthetic data is motivated by lowering costs and engineering effort.In real-world experiments we confirm that we achieved successful sim-to-real policy transfer. Based on the extensive evaluation, we analyze how design decisions about perception, control, and training impact the real-world performance.