Text-attributed graphs (TAGs) enhance graph learning by integrating rich textual semantics and topological context for each node. While boosting expressiveness, they also expose new vulnerabilities in graph learning through text-based adversarial surfaces. Recent advances leverage diverse backbones, such as graph neural networks (GNNs) and pre-trained language models (PLMs), to capture both structural and textual information in TAGs. This diversity raises a key question: How can we design universal adversarial attacks that generalize across architectures to assess the security of TAG models? The challenge arises from the stark contrast in how different backbones—GNNs and PLMs—perceive and encode graph patterns, coupled with the fact that many PLMs are only accessible via APIs, limiting attacks to black-box settings. To address this, we propose BadGraph, a novel attack framework that deeply elicits large language models' (LLMs) understanding of general graph knowledge to jointly perturb both node topology and textual semantics. Specifically, we design a target influencer retrieval module that leverages graph priors to construct cross-modally aligned attack shortcuts, thereby enabling efficient LLM-based perturbation reasoning. Experiments show that BadGraph achieves universal and effective attacks across GNN- and LLM-based reasoners, with up to a 76.3% performance drop, while theoretical and empirical analyses confirm its stealthy yet interpretable nature.

Heterogeneous Graph Neural Networks (HGNNs) are vulnerable, highlighting the need for tailored attacks to assess their robustness and ensure security. However, existing HGNN attacks often require complex retraining of parameters to generate specific perturbations for new scenarios. Recently, foundation models have opened new horizons for the generalization of graph neural networks by capturing shared semantics across various graph distributions. This leads us to ask: Can we design a foundation attack model for HGNNs that enables generalizable perturbations across different HGNNs, and quickly adapts to new heterogeneous graphs (HGs)? Empirical findings reveal that, despite significant differences in model design and parameter space, different HGNNs surprisingly share common vulnerability patterns from a relation-aware perspective. Therefore, we explore how to design foundation HGNN attack criteria by mining shared attack units. In this paper, we propose a novel relation-wise heterogeneous graph foundation attack model, HeTa. We introduce a foundation surrogate model to align heterogeneity and identify the importance of shared relation-aware attack units. Building on this, we implement a serialized relation-by-relation attack based on the identified relational weights. In this way, the perturbation can be transferred to various target HGNNs and easily fine-tuned for new HGs. Extensive experiments exhibit powerful attack performances and generalizability of our method.

Taste peptides have emerged as promising natural flavoring agents attributed to their unique organoleptic properties, high safety profile, and potential health benefits. However, the de novo identification of taste peptides derived from animal, plant, or microbial sources remains a time-consuming and resource-intensive process, significantly impeding their widespread application in the food industry. In this work, we present TastePepAI, a comprehensive artificial intelligence framework for customized taste peptide design and safety assessment. As the key element of this framework, a loss-supervised adaptive variational autoencoder (LA-VAE) is implemented to efficiently optimize the latent representation of sequences during training and facilitate the generation of target peptides with desired taste profiles. Notably, our model incorporates a novel taste-avoidance mechanism, allowing for selective flavor exclusion. Subsequently, our in-house developed toxicity prediction algorithm (SpepToxPred) is integrated in the framework to undergo rigorous safety evaluation of generated peptides. Using this integrated platform, we successfully identified 73 peptides exhibiting sweet, salty, and umami, significantly expanding the current repertoire of taste peptides. This work demonstrates the potential of TastePepAI in accelerating taste peptide discovery for food applications and provides a versatile framework adaptable to broader peptide engineering challenges.