We present a demonstration of a highly scalable, spatially explicit infectious disease simulation that models the spread of disease across all 220,000+ census block groups in the United States using a compartmental Susceptible-Infectious-Recovered (SIR) epidemiological framework. To achieve this unprecedented scale and resolution, our system leverages efficient sparse matrix and vector operations alongside statistical approximations of large numbers of independent random events via Poisson and Normal distributions. The resulting simulation produces realistic spatiotemporal dynamics that align with empirical patterns observed in major epidemics, including the COVID-19 outbreak. Our live demonstration at the conference will highlight the simulation's computational efficiency and interactive capabilities. Starting from the conference venue in Minneapolis, participants will be able to configure disease parameters and observe the geographic spread of infection in real time, offering both an educational and analytical perspective on pandemic modeling.

Pathogen genome data offers valuable structure for spatial models, but its utility is limited by incomplete sequencing coverage. We propose a probabilistic framework for inferring genetic distances between unsequenced cases and known sequences within defined transmission chains, using time-aware evolutionary distance modeling. The method estimates pairwise divergence from collection dates and observed genetic distances, enabling biologically plausible imputation grounded in observed divergence patterns, without requiring sequence alignment or known transmission chains. Applied to highly pathogenic avian influenza A/H5 cases in wild birds in the United States, this approach supports scalable, uncertainty-aware augmentation of genomic datasets and enhances the integration of evolutionary information into spatiotemporal modeling workflows.

Massive datasets related to infectious diseases became available after the COVID-19 pandemic, supporting data-driven approaches in modeling and forecasting infectious diseases. However, these approaches are known to exacerbate data biases present in the training data such as having certain demographic groups being over or underrepresented in the data. Such data collection biases may propagate through the modeling and prediction pipelines to decision-making, and the consequences are relatively unknown. Therefore, efforts are needed to understand how data collection bias affects data-driven infectious disease models. This datasets and benchmarks paper provides a suite of datasets, each corresponding to a simulated disease spread among a population of 5000 simulated agents over 90 days in Atlanta and San Francisco. For each dataset, we provide not only the full (simulated ground truth) of the disease spread in terms of when, where, and by whom the disease spreads, but also information on which cases are observed when different types and degrees of data collection bias are applied. The agents' characteristics, check-ins, and social network data are also available to support downstream tasks. Additionally, we also describe how to use the simulation to re-generate the data and to generate new datasets in different regions and with different parameters. With the provided datasets and the simulation tools, researchers studying the spread of infectious diseases may better understand, account for, and correct the systematic bias caused by the inherent real-world data bias, and hence improve the prediction of infectious diseases.

‘Watch The Flu’ is a tool that monitors tweets posted in Australia for symptoms of influenza. The tool is a unique combination of two areas of artificial intelligence: natural language processing and time series monitoring, in order to assist public health surveillance. Using a real-time data pipeline, it deploys a web-based dashboard for visual analysis, and sends out emails to a set of users when an outbreak is detected. We expect that the tool will assist public health experts with their decision-making for disease outbreaks, by providing them insights from social media.