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Tábita Hünemeier

dblp:224/0347 · DBLP profile ↗
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1ranked-venue papers
0as first author
1since 2021 · last 2023
0000-0002-3156-2079ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%
Theoretical computer science
1 paper
Information theory · 100%

Topics — the 2 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › population genetics
population genomics
0.712023
Population-based change-point detection for the identification of homozygosity islands · Bioinform. 2023
Information theory › hypothesis testing
change-point detection
0.712023
Population-based change-point detection for the identification of homozygosity islands · Bioinform. 2023

Methods — techniques the papers use, named apart from their topics

penalized maximum likelihood · 1.3dynamic programming · 1.3binary segmentation · 1.3
YearPublicationVenuePosition
2023 Population-based change-point detection for the identification of homozygosity islands
abstract
MOTIVATION: This work is motivated by the problem of identifying homozygosity islands on the genome of individuals in a population. Our method directly tackles the issue of identification of the homozygosity islands at the population level, without the need of analysing single individuals and then combine the results, as is made nowadays in state-of-the-art approaches. RESULTS: We propose regularized offline change-point methods to detect changes in the parameters of a multidimensional distribution when we have several aligned, independent samples of fixed resolution. We present a penalized maximum likelihood approach that can be efficiently computed by a dynamic programming algorithm or approximated by a fast binary segmentation algorithm. Both estimators are shown to converge almost surely to the set of change-points without the need of specifying a priori the number of change-points. In simulation, we observed similar performances from the exact and greedy estimators. Moreover, we provide a new methodology for the selection of the regularization constant which has the advantage of being automatic, consistent, and less prone to subjective analysis. AVAILABILITY AND IMPLEMENTATION: The data used in the application are from the Human Genome Diversity Project (HGDP) and is publicly available. Algorithms were implemented using the R software R Core Team (R: A Language and Environment for Statistical Computing. Vienna (Austria): R Foundation for Statistical Computing, 2020.) in the R package blockcpd, found at https://github.com/Lucas-Prates/blockcpd.
Lucas Prates, Renan B. Lemes, Tábita Hünemeier, Florencia G. Leonardi
Bioinform.3