Abstract. We consider the time and space required for quantum computers to solve a wide variety of problems involving matrices, many of which have only been analyzed classically in prior work. Our main results show that for a range of linear algebra problems—including matrix-vector product, matrix inversion, matrix multiplication and powering—existing classical time-space tradeoffs, several of which are tight for every space bound, also apply to quantum algorithms with at most a constant factor loss. For example, for almost all fixed matrices [Formula: see text], including the discrete Fourier transform matrix, we prove that quantum circuits with at most [Formula: see text] input queries and [Formula: see text] qubits of memory require [Formula: see text] to compute matrix-vector product [Formula: see text] for [Formula: see text]. We similarly prove that matrix multiplication for [Formula: see text] binary matrices requires [Formula: see text]. Because many of our lower bounds are matched by deterministic algorithms with the same time and space complexity, our results show that quantum computers cannot provide any asymptotic advantage for these problems with any space bound. We obtain matching lower bounds for the stronger notion of quantum cumulative memory complexity—the sum of the space per layer of a circuit. We also consider Boolean (i.e., AND-OR) matrix multiplication and matrix-vector products, improving the previous quantum time-space tradeoff lower bounds for [Formula: see text] Boolean matrix multiplication to [Formula: see text] from [Formula: see text]. Our improved lower bound for Boolean matrix multiplication is based on a new coloring argument that extracts more from the strong direct product theorem that was the basis for prior work. To obtain our tight lower bounds for linear algebra problems, we require much stronger bounds than strong direct product theorems. We obtain these bounds by adding a new bucketing method to the quantum recording-query technique of Zhandry that lets us apply classical arguments to upper bound the success probability of quantum circuits.

We prove lower bounds on the time and space required for quantum computers to solve a wide variety of problems involving matrices, many of which have only been analyzed classically in prior work. Using a novel way of applying recording query methods we show that for many linear algebra problems—including matrix-vector product, matrix inversion, matrix multiplication and powering—existing classical time-space tradeoffs also apply to quantum algorithms with at most a constant factor loss. For example, for almost all fixed matrices A, including the discrete Fourier transform (DFT) matrix, we prove that quantum circuits with at most T input queries and S qubits of memory require T=Ω(n2/S) to compute matrix-vector product Ax for x ∈ {0,1}n. We similarly prove that matrix multiplication for n× n binary matrices requires T=Ω(n3 / √S). Because many of our lower bounds are matched by deterministic algorithms with the same time and space complexity, our results show that quantum computers cannot provide any asymptotic advantage for these problems at any space bound. We also improve the previous quantum time-space tradeoff lower bounds for n× n Boolean (i.e. AND-OR) matrix multiplication from T=Ω(n2.5/S1/2) to T=Ω(n2.5/S1/4) which has optimal exponents for the powerful query algorithms to which it applies. Our method also yields improved lower bounds for classical algorithms.

Cumulative memory - the sum of space used per step over the duration of a computation - is a fine-grained measure of time-space complexity that was introduced to analyze cryptographic applications like password hashing. It is a more accurate cost measure for algorithms that have infrequent spikes in memory usage and are run in environments such as cloud computing that allow dynamic allocation and de-allocation of resources during execution, or when many multiple instances of an algorithm are interleaved in parallel. We prove the first lower bounds on cumulative memory complexity for both sequential classical computation and quantum circuits. Moreover, we develop general paradigms for bounding cumulative memory complexity inspired by the standard paradigms for proving time-space tradeoff lower bounds that can only lower bound the maximum space used during an execution. The resulting lower bounds on cumulative memory that we obtain are just as strong as the best time-space tradeoff lower bounds, which are very often known to be tight. Although previous results for pebbling and random oracle models have yielded time-space tradeoff lower bounds larger than the cumulative memory complexity, our results show that in general computational models such separations cannot follow from known lower bound techniques and are not true for many functions. Among many possible applications of our general methods, we show that any classical sorting algorithm with success probability at least 1/poly(n) requires cumulative memory ̃ Ω(n²), any classical matrix multiplication algorithm requires cumulative memory Ω(n⁶/T), any quantum sorting circuit requires cumulative memory Ω(n³/T), and any quantum circuit that finds k disjoint collisions in a random function requires cumulative memory Ω(k³n/T²).

Biological regulatory networks depend upon chemical interactions to process information. Engineering such molecular computing systems is a major challenge for synthetic biology and related fields. The chemical reaction network (CRN) model idealizes chemical interactions, allowing rigorous reasoning about the computational power of chemical kinetics. Here we focus on function computation with CRNs, where we think of the initial concentrations of some species as the input and the equilibrium concentration of another species as the output. Specifically, we are concerned with CRNs that are rate-independent (the computation must be correct independent of the reaction rate law) and composable ( f°g can be computed by concatenating the CRNs computing f and g). Rate independence and composability are important engineering desiderata, permitting implementations that violate mass-action kinetics, or even "well-mixedness", and allowing the systematic construction of complex computation via modular design. We show that to construct composable rate-independent CRNs, it is necessary and sufficient to ensure that the output species of a module is not a reactant in any reaction within the module. We then exactly characterize the functions computable by such CRNs as superadditive, positive-continuous, and piecewise rational linear. Thus composability severely limits rate-independent computation unless more sophisticated input/output encodings are used.