Current 3D Gaussian Splatting methods often overlook structured information, leading to disorganized 3D Gaussians that compromise memory and structure efficiency, particularly in Level-of-Detail (LOD) management. This inefficiency results in excessive memory use, limiting their application in resource-sensitive environments like virtual reality and interactive simulations. To overcome these challenges, we introduce a scalable Gaussian Soup that enables high-performance LOD management with progressively reduced memory usage. Our method utilizes triangle primitives with Gaussian splats embedded and adaptive pruning/growing strategies to ensure high-quality scene rendering with significantly reduced memory demands. By embedding neural Gaussians within the triangle primitives through the triangle-MLP, we achieve further memory savings while maintaining rendering fidelity. Experimental results demonstrate that our approach achieves consistently superior performance than recent leading techniques across various LOD while progressively reducing memory usage.

Current methods based on Neural Radiance Fields (NeRF) significantly lack the capacity to quantify uncertainty in their predictions, particularly on the unseen space including the occluded and outside scene content. This limitation hinders their extensive applications in robotics, where the reliability of model predictions has to be considered for tasks such as robotic exploration and planning in unknown environments. To address this, we propose a novel approach to estimate a 3D Uncertainty Field based on the learned incomplete scene geometry, which explicitly identifies these unseen regions. By considering the accumulated transmittance along each camera ray, our Uncertainty Field infers 2D pixel-wise uncertainty, exhibiting high values for rays directly casting towards occluded or outside the scene content. To quantify the uncertainty on the learned surface, we model a stochastic radiance field. Our experiments demonstrate that our approach is the only one that can explicitly reason about high uncertainty both on 3D unseen regions and its involved 2D rendered pixels, compared with recent methods. Furthermore, we illustrate that our designed uncertainty field is ideally suited for real-world robotics tasks, such as next-best-view selection.

Neural Radiance Fields (NeRF) has become a popular framework for learning implicit 3D representations and addressing different tasks such as novel-view synthesis or depth-map estimation. However, in downstream applications where decisions need to be made based on automatic predictions, it is critical to leverage the confidence associated with the model estimations. Whereas uncertainty quantification is a long-standing problem in Machine Learning, it has been largely overlooked in the recent NeRF literature. In this context, we propose Stochastic Neural Radiance Fields (S-NeRF), a generalization of standard NeRF that learns a probability distribution over all the possible radiance fields modeling the scene. This distribution allows to quantify the uncertainty associated with the scene information provided by the model. S-NeRF optimization is posed as a Bayesian learning problem that is efficiently addressed using the Variational Inference framework. Exhaustive experiments over benchmark datasets demonstrate that S-NeRF is able to provide more reliable predictions and confidence values than generic approaches previously proposed for uncertainty estimation in other domains.

Tumor suppressor genes (TSGs) exhibit distinct evolutionary features. We speculated that TSG promoters could have evolved specific features that facilitate their tumor-suppressing functions. We found that the promoter CpG dinucleotide frequencies of TSGs are significantly higher than that of non-cancer genes across vertebrate genomes, and positively correlated with gene expression across tissue types. The promoter CpG dinucleotide frequencies of all genes gradually increase with gene age, for which young TSGs have been subject to a stronger evolutionary pressure. Transcription-related features, namely chromatin accessibility, methylation and ZNF263-, SP1-, E2F4- and SP2-binding elements, are associated with gene expression. Moreover, higher promoter CpG dinucleotide frequencies and chromatin accessibility are positively associated with the ability of TSGs to resist downregulation during tumorigenesis. These results were successfully validated with independent datasets. In conclusion, TSGs evolved specific promoter features that optimized cancer resistance through achieving high expression in normal tissues and resistance to downregulation during tumorigenesis.

Patients with spinal muscular atrophy (SMA) are susceptible to the respiratory infections and might be at a heightened risk of poor clinical outcomes upon contracting coronavirus disease 2019 (COVID-19). In the face of the COVID-19 pandemic, the potential associations of SMA with the susceptibility to and prognostication of COVID-19 need to be clarified. We documented an SMA case who contracted COVID-19 but only developed mild-to-moderate clinical and radiological manifestations of pneumonia, which were relieved by a combined antiviral and supportive treatment. We then reviewed a cohort of patients with SMA who had been living in the Hubei province since November 2019, among which the only 1 out of 56 was diagnosed with COVID-19 (1.79%, 1/56). Bioinformatic analysis was carried out to delineate the potential genetic crosstalk between SMN1 (mutation of which leads to SMA) and COVID-19/lung injury-associated pathways. Protein-protein interaction analysis by STRING suggested that loss-of-function of SMN1 might modulate COVID-19 pathogenesis through CFTR, CXCL8, TNF and ACE. Expression quantitative trait loci analysis also revealed a link between SMN1 and ACE2, despite low-confidence protein-protein interactions as suggested by STRING. This bioinformatic analysis could give hint on why SMA might not necessarily lead to poor outcomes in patients with COVID-19.