Event co-occurrences have been proven effective for event argument extraction (EAE) in previous studies; however, few have considered intra- and inter-event role correlations. Since role varies among different event types, event structure heterogeneity and overlap pose significant challenges to EAE. To address this issue, we propose a Role Correlation Structure-Enhanced model for Multi-Event Argument Extraction (RoSE), capable of capturing both heterogeneity and overlap of event structures through modeling role correlations. The proposed RoSE model employs a joint context-prompts input, role-centric graph-guided encoder (RoGE), and role-specific information fusion (RoIF). The RoGE is designed to enhance the intra- and inter-event role correlation between prompts and their corresponding event contexts. The RoIF module utilizes intra-event role information to improve multi-event arguments extraction. Extensive experiments on four widely-used benchmarks (RAMS, WikiEvents, MLEE, and ACE05) demonstrate that our proposed approach achieves state-of-the-art performance, validating the effectiveness of incorporating both intra- and inter-event role correlations.

Data economics drives AI by optimizing data usage, reducing costs, and enhancing efficiency. In 3D tumor segmentation, efficiency is crucial due to the high demand for labor-intensive manual annotations. Box-supervised segmentation offers a promising alternative but is constrained by tumor morphology complexity and boundary ambiguity. In this paper, we propose a novel 3D tumor segmentation model that integrates both positional and embedding features to facilitate inter-task collaboration. We introduce an Anatomical-Driven Class Activation Map to predefine the complex tumor morphology prior, which is further refined by our Geometric Pixel Co-embedding Learner. This learner utilizes contrastive learning to encode semantic information between center and edge pixels, enhancing pixel clustering and progressively refining tumor boundary segmentation in a coarse-to-fine manner. Our approach outperforms existing box-supervised methods in segmentation performance, with extensive experiments on four tumor datasets demonstrating significant improvements. This work provides a cost-effective and efficient solution for tumor segmentation, advancing the application of data economics in medical imaging.

Entity hallucination poses a major challenge in radiology report generation (RRG), particularly for 3D CT scans where complex spatial contexts amplify factual errors. To address this, medical entity phrases serve as key carriers for multi-modal prompting, integrating expert knowledge into the vision-language model. Current methods use unified cross-attention for volume-phrase alignment, failing to account for anatomical specificity during the alignment process. In this work, we introduce the Dual-stream Entity Alignment Reporting network (DEAR) that separately models organ and lesion entities to resolve anatomical bias. Specifically, the dual-stream entity aligner is designed to partition medical entity phrases into organ and lesion streams, feeding them into separate cross-attention blocks in parallel to achieve fine-grained volume–phrase alignment. For structurally regular and spatially stable organ entities, an organ-guided cross-attention (OGCA) block is proposed to enforce structural consistency by retrieving the top-k voxel tokens via volume–phrase similarity and preserving spatial connectivity through morphological dilation. Meanwhile, a lesion-guided cross-attention (LGCA) block is introduced for structurally irregular and spatially variable lesion entities, enhancing anomaly sensitivity through phrase-weighted attention and refining discriminative boundaries via 3D residual Laplacian filtering. Experiments demonstrate that DEAR significantly reduces entity hallucinations and improves clinical factuality in 3D RRG benchmarks.

Deep learning-based tumor segmentation methods typically require precise pixel-level annotations, which are costly in clinical practice. While bounding box supervision offers a more efficient alternative, existing approaches assume unrealistically tight box annotations, leading to performance degradation when applied to the loose boxes commonly produced by medical annotators. To address this challenge, we propose LooBox, a novel 3D segmentation framework that utilizes loose box annotations through a self-correction and bidirectional rectification paradigm. For the self-correction part, we propose a noise cleaner that comprehensively utilizes deterministic outer box information by integrating three complementary perspectives for predictive self-rectification: entropy mapping, gradient monitoring, and foreground-background affinity measurement. For the bidirectional rectification part, we introduce an augmentation-driven comprehensive consistency constraint strategy. Specifically, the framework incorporates: an asymmetric co-teaching architecture comprising a basic UNet and an enhanced UNet variant with a noise adapter, and an augmentation-driven consistency mechanism that computes pairwise loss between self-corrected predictions after each training iteration to ensure robust tumor feature extraction. Comprehensive evaluations on LIDC-IDRI, MSD-Lung, and MSD-Pancreas datasets demonstrate that LooBox achieves superior segmentation accuracy compared to state-of-the-art box-supervised methods.

Segmentation of the airway tree plays a vital role in clinical practice. However, the complex airway tree structure makes it quite challenging to annotate accurately. Although some annotation-efficient methods have shown promising results in medical image segmentation, most are developed for locally focused segmentation objects and are incompatible with the airway. In this work, we propose an annotation-efficient segmentation method to improve annotation efficiency and tree completeness. It includes a new efficient annotation way and an accompanying segmentation method. The saliency-based annotation method only needs to annotate high-saliency regions, thus greatly improving the annotation efficiency. Inspired by positive-unlabeled learning, we model the dependency relationship between key items in the annotation process to learn from biased weak annotation. The probabilistic model of the annotation process is divided into the score function and the bias function. The score function models the uniform foreground feature representation of the airway, while the bias function models the saliency bias between labeled and unlabeled airway regions. Then, the two models are implemented with convolutional neural networks and optimized by applying an EM algorithm during training. Experimental results reveal that our approach saves 89% annotation time and significantly narrows the performance gap between weak and full annotations. This highlights its potential for clinical applications.

The deep neural network, based on the backpropagation learning algorithm, has achieved tremendous success. However, the backpropagation algorithm is consistently considered biologically implausible. Many efforts have recently been made to address these biological implausibility issues, nevertheless, these methods are tailored to discrete neural network structures. Continuous neural networks are crucial for investigating novel neural network models with more biologically dynamic characteristics and for interpretability of large language models. The neural memory ordinary differential equation (nmODE) is a recently proposed continuous neural network model that exhibits several intriguing properties. In this study, we present a forward-learning algorithm, called nmForwardLA, for nmODE. This algorithm boasts lower computational dimensions and greater efficiency. Compared with the other learning algorithms, experimental results on MNIST, CIFAR10, and CIFAR100 demonstrate its potency.

Thoracic computed tomography (CT) currently plays the primary role in pulmonary nodule detection, where the reconstruction kernel significantly impacts performance in computer-aided pulmonary nodule detectors. The issue of kernel selection affecting performance has been overlooked in pulmonary nodule detection. This paper first introduces a novel pulmonary nodule detection dataset named Reconstruction Kernel Imaging for Pulmonary Nodule Detection (RKPN) for quantifying algorithm differences between the two imaging types. The dataset contains pairs of images taken from the same patient on the same date, featuring both smooth (B31f) and sharp kernel (B60f) reconstructions. All other imaging parameters and pulmonary nodule labels remain entirely consistent across these pairs. Extensive quantification reveals mainstream detectors perform better on smooth kernel imaging than on sharp kernel imaging. To address suboptimal detection on the sharp kernel imaging, we further propose an image conversion-based pulmonary nodule detector called ICNoduleNet. A lightweight 3D slice-channel converter (LSCC) module is introduced to convert sharp kernel images into smooth kernel images, which can sufficiently learn inter-slice and inter-channel feature information while avoiding introducing excessive parameters. We conduct thorough experiments that validate the effectiveness of ICNoduleNet, it takes sharp kernel images as input and can achieve comparable or even superior detection performance to the baseline that uses the smooth kernel images. The evaluation shows promising results and proves the effectiveness of ICNoduleNet.

Radiographic attributes of lung nodules remedy the shortcomings of lung cancer computer-assisted diagnosis systems, which provides interpretable diagnostic reference for doctors. However, current studies fail to dedicate multi-label classification of lung nodules using convolutional neural networks (CNNs) and are inferior in exploiting statistical dependency between the labels. In addition, data imbalance is an indispensable problem to be reckoned with when employing CNNs to perform lung nodule classification. It introduces greater challenges especially in the multi-label classification. In this paper, we propose a method called MLSL-Net to discriminate lung nodule characteristics and simultaneously address the challenges. Particularly, the proposal employs multi-label softmax loss (MLSL) as the performance index, aiming to reduce the ranking errors between the labels and within the labels during training, thereby optimizing ranking loss and AUC directly. Such criterions can better evaluate the classifier's performance on the multi-label imbalanced dataset. Furthermore, a scale factor is introduced based on the investigation of the max surrogate function. Different from preceding usages, the small factor is used so that to narrow the discrepancy of gradients produced by different labels. More interestingly, this factor also facilitates the exploit of label dependency. Experimental results on the LIDC-IDRI dataset as well as another akin dataset demonstrate that MLSL-Net can effectively perform multi-label classification despite the imbalance issue. Meanwhile, the results confirm the responsibility of the factor for capturing label correlations, accordingly leading to more accurate predictions.

Lung cancer postoperative complication prediction (PCP) is significant for decreasing the perioperative mortality rate after lung cancer surgery. In this paper we concentrate on two PCP tasks: (1) the binary classification for predicting whether a patient will have postoperative complications; and (2) the three-class multi-label classification for predicting which postoperative complication a patient will experience. Furthermore, an important clinical requirement of PCP is the extraction of crucial variables from electronic medical records. We propose a novel multi-layer perceptron (MLP) model called medical MLP (MediMLP) together with the gradient-weighted class activation mapping (Grad-CAM) algorithm for lung cancer PCP. The proposed MediMLP, which involves one locally connected layer and fully connected layers with a shortcut connection, simultaneously extracts crucial variables and performs PCP tasks. The experimental results indicated that MediMLP outperformed normal MLP on two PCP tasks and had comparable performance with existing feature selection methods. Using MediMLP and further experimental analysis, we found that the variable of "time of indwelling drainage tube" was very relevant to lung cancer postoperative complications.