Objective gait assessment in Parkinson’s Disease (PD) is limited by the absence of large, diverse, and clinically annotated motion datasets. We introduce Care-PD, the largest publicly available archive of 3D mesh gait data for PD, and the first multi-site collection spanning 9 cohorts from 8 clinical centers. All recordings (RGB video or motion capture) are converted into anonymized SMPL meshes via a harmonized preprocessing pipeline. Care-PD supports two key benchmarks: supervised clinical score prediction (estimating Unified Parkinson’s Disease Rating Scale, UPDRS, gait scores) and unsupervised motion pretext tasks (2D-to-3D keypoint lifting and full-body 3D reconstruction). Clinical prediction is evaluated under four generalization protocols: within-dataset, cross-dataset, leave-one-dataset-out, and multi-dataset in-domain adaptation.To assess clinical relevance, we compare state-of-the-art motion encoders with a traditional gait-feature baseline, finding that encoders consistently outperform handcrafted features. Pretraining on Care-PD reduces MPJPE (from 60.8mm to 7.5mm) and boosts PD severity macro-F1 by 17\%, underscoring the value of clinically curated, diverse training data. Care-PD and all benchmark code are released for non-commercial research (Code, Data).

Current test-time adaptation (TTA) approaches aim to adapt a machine learning model to environments that change continuously. Yet, it is unclear whether TTA methods can maintain their adaptability over prolonged periods. To answer this question, we introduce a diagnostic setting - **recurring TTA** where environments not only change but also recur over time, creating an extensive data stream. This setting allows us to examine the error accumulation of TTA models, in the most basic scenario, when they are regularly exposed to previous testing environments. Furthermore, we simulate a TTA process on a simple yet representative $\epsilon$-**perturbed Gaussian Mixture Model Classifier**, deriving theoretical insights into the dataset- and algorithm-dependent factors contributing to gradual performance degradation. Our investigation leads us to propose **persistent TTA (PeTTA)**, which senses when the model is diverging towards collapse and adjusts the adaptation strategy, striking a balance between the dual objectives of adaptation and model collapse prevention. The supreme stability of PeTTA over existing approaches, in the face of lifelong TTA scenarios, has been demonstrated over comprehensive experiments on various benchmarks. Our project page is available at [https://hthieu166.github.io/petta](https://hthieu166.github.io/petta).

Understanding the efficacy of digital biomarkers in vision-based human motion analysis is essential, not only for interpreting the computer-aided exam results but also for advancing the next generation of digital health tool solutions. This study extensively analyzes digitized neurological examination (DNE) biomarkers for detecting and documenting exam features of Parkinson's disease (PD) and other neurological disorders (OD). Collected over 113 participants, DNE-113, a multi-test DNE database of finger tapping, finger to finger, forearm roll, stand-up and walk, and facial activation tests, covering a broader range of neurological abnormalities beyond PD is first proposed. Subsequently, DNE-113 is integrated into pyDNE - a convenient open-source toolbox, streamlining the creation and assessment of digital biomarkers. This toolbox empowers us to assess the quality of DNE biomarkers across diverse classification tasks. We showcase the discriminative potency of DNE biomarkers, successfully characterizing abnormal signals in neurological patients. Our findings highlight not only the potential use cases but also the persisting challenges in constructing digital biomarkers for computer-aided movement analysis on PD and OD patients.

Cross-silo privacy-preserving federated learning (PPFL) is a powerful tool to collaboratively train robust and generalized machine learning (ML) models without sharing sensitive (e.g., healthcare of financial) local data. To ease and accelerate the adoption of PPFL, we introduce APPFLx, a ready-to-use platform that provides privacy-preserving cross-silo federated learning as a service. APPFLx employs Globus authentication to allow users to easily and securely invite trustworthy collaborators for PPFL, implements several synchronous and asynchronous FL algorithms, streamlines the FL experiment launch process, and enables tracking and visualizing the life cycle of FL experiments, allowing domain experts and ML practitioners to easily orchestrate and evaluate cross-silo FL under one platform. APPFLx is available online at https://appflx.link

The ability to use digitally recorded and quantified neurological exam information is important to help healthcare systems deliver better care, in-person and via telehealth, as they compensate for a growing shortage of neurologists. Current neurological digital biomarker pipelines, however, are narrowed down to a specific neurological exam component or applied for assessing specific conditions. In this paper, we propose an accessible vision-based exam and documentation solution called Digitized Neurological Examination (DNE) to expand exam biomarker recording options and clinical applications using a smartphone/tablet. Through our DNE software, healthcare providers in clinical settings and people at home are enabled to video capture an examination while performing instructed neurological tests, including finger tapping, finger to finger, forearm roll, and stand-up and walk. Our modular design of the DNE software supports integrations of additional tests. The DNE extracts from the recorded examinations the 2D/3D human-body pose and quantifies kinematic and spatio-temporal features. The features are clinically relevant and allow clinicians to document and observe the quantified movements and the changes of these metrics over time. A web server and a user interface for recordings viewing and feature visualizations are available. DNE was evaluated on a collected dataset of 21 subjects containing normal and simulated-impaired movements. The overall accuracy of DNE is demonstrated by classifying the recorded movements using various machine learning models. Our tests show an accuracy beyond 90% for upper-limb tests and 80% for the stand-up and walk tests.

In this paper, we introduce a practical system for interactive video object mask annotation, which can support multiple back-end methods. To demonstrate the generalization of our system, we introduce a novel approach for video object annotation. Our proposed system takes scribbles at a chosen key-frame from the end-users via a user-friendly interface and produces masks of corresponding objects at the key-frame via the Control-Point-based Scribbles-to-Mask (CPSM) module. The object masks at the key-frame are then propagated to other frames and refined through the Multi-Referenced Guided Segmentation (MRGS) module. Last but not least, the user can correct wrong segmentation at some frames, and the corrected mask is continuously propagated to other frames in the video via the MRGS to produce the object masks at all video frames.

Gastrointestinal (GI) endoscopy has been an active field of research motivated by the large number of highly lethal GI cancers. Early GI cancer precursors are often missed during the endoscopic surveillance. The high missed rate of such abnormalities during endoscopy is thus a critical bottleneck. Lack of attentiveness due to tiring procedures, and requirement of training are few contributing factors. An automatic GI disease classification system can help reduce such risks by flagging suspicious frames and lesions. GI endoscopy consists of several multi-organ surveillance, therefore, there is need to develop methods that can generalize to various endoscopic findings. In this realm, we present a comprehensive analysis of the Medico GI challenges: Medical Multimedia Task at MediaEval 2017, Medico Multimedia Task at MediaEval 2018, and BioMedia ACM MM Grand Challenge 2019. These challenges are initiative to set-up a benchmark for different computer vision methods applied to the multi-class endoscopic images and promote to build new approaches that could reliably be used in clinics. We report the performance of 21 participating teams over a period of three consecutive years and provide a detailed analysis of the methods used by the participants, highlighting the challenges and shortcomings of the current approaches and dissect their credibility for the use in clinical settings. Our analysis revealed that the participants achieved an improvement on maximum Mathew correlation coefficient (MCC) from 82.68% in 2017 to 93.98% in 2018 and 95.20% in 2019 challenges, and a significant increase in computational speed over consecutive years.

Inspired by recent advances in computer vision and deep learning, we propose new enhancements to tackle problems appearing in endoscopic image analysis, especially abnormality finding and anatomical landmark detection. In details, a combination of Residual Neural Network and Faster R-CNN are jointly applied in order to take all of their advantages and improve the overall performance. Nevertheless, novel data augmentation is designed and adapted to corresponding domains. Our approaches prove their competitive results in term of not only the accuracy but also the inference time in Medico: The 2018 Multimedia for Medicine Task and The Biomedia ACM MM Grand Challenge 2019. These results show the great potential of the collaborating between deep learning models and data augmentation in medical image analysis applications. Especially, more than 4900 bounding boxes localizing the symptom of some classes from KVASIR dataset that we annotated and used in this project are shared online for future research.