Sequencing-based microbial count data analysis is a challenging task due to the presence of numerous non-biological zeros, which can impede downstream analysis. To tackle this issue, we introduce two novel approaches, PhyImpute and UniFracImpute, which leverage similar microbial samples to identify and impute non-biological zeros in microbial count data. Our proposed methods utilize the probability of non-biological zeros and phylogenetic trees to estimate sample-to-sample similarity, thus addressing this challenge. To evaluate the performance of our proposed methods, we conduct experiments using both simulated and real microbial data. The results demonstrate that PhyImpute and UniFracImpute outperform existing methods in recovering the zeros and empowering downstream analyses such as differential abundance analysis, and disease status classification.

Call-and-response is a musical technique that enriches the creativity of music, crafting coherent musical ideas that mirror the back-and-forth nature of human dialogue with distinct musical characteristics. Although this technique is integral to numerous musical compositions, it remains largely uncharted in automatic music composition. To enhance the creativity of machine-composed music, we first introduce the Call-Response Dataset (CRD) containing 19,155 annotated musical pairs and crafted comprehensive objective evaluation metrics for musical assessment. Then, we design a knowledge-enhanced learning-based method to bridge the gap between human and machine creativity. Specifically, we train the composition module using the call-response pairs, supplementing it with musical knowledge in terms of rhythm, melody, and harmony. Our experimental results underscore that our proposed model adeptly produces a wide variety of creative responses for various musical calls.