Quantum error correction (QEC) is essential for scalable quantum computing, yet repeated syndrome-measurement cycles dominate its spacetime and hardware cost. Although stabilizers commute and admit many valid execution orders, different schedules induce distinct error-propagation paths under realistic noise, leading to large variations in logical error rate. Outside of surface codes, effective syndrome-measurement scheduling remains largely unexplored. We present AlphaSyndrome, an automated synthesis framework for scheduling syndrome-measurement circuits in general commuting-stabilizer codes under minimal assumptions: mutually commuting stabilizers and a heuristic decoder. AlphaSyndrome formulates scheduling as an optimization problem that shapes error propagation to (i) avoid patterns close to logical operators and (ii) remain within the decoder's correctable region. The framework uses Monte Carlo Tree Search (MCTS) to explore ordering and parallelism, guided by code structure and decoder feedback. Across diverse code families, sizes, and decoders, AlphaSyndrome reduces logical error rates by 80.6% on average (up to 96.2%) relative to depth-optimal baselines, matches Google's hand-crafted surface-code schedules, and outperforms IBM's schedule for the Bivariate Bicycle code.

Quantum Error Correction (QEC) codes are essential for achieving fault-tolerant quantum computing (FTQC). However, their implementation faces significant challenges due to disparity between required dense qubit connectivity and sparse hardware architectures. Current approaches often either underutilize QEC circuit features or focus on manual designs tailored to specific codes and architectures, limiting their capability and generality. In response, we introduce QECC-Synth, an automated compiler for QEC code implementation that addresses these challenges. We leverage the ancilla bridge technique tailored to the requirements of QEC circuits and introduces a systematic classification of its design space flexibilities. We then formalize this problem using the MaxSAT framework to optimize these flexibilities. Evaluation shows that our method significantly outperforms existing methods while demonstrating broader applicability across diverse QEC codes and hardware architectures.

This paper introduces the Hamiltonian-Adaptive Ternary Tree (HATT) framework to compile optimized Fermion-to-qubit mapping for specific Fermionic Hamiltonians. In the simulation of Fermionic quantum systems, efficient Fermion-toqubit mapping plays a critical role in transforming the Fermionic system into a qubit system. HATT utilizes ternary tree mapping and a bottom-up construction procedure to generate Hamiltonian aware Fermion-to-qubit mapping to reduce the Pauli weight of the qubit Hamiltonian, resulting in lower quantum simulation circuit overhead. Additionally, our optimizations retain the important vacuum state preservation property in our Fermion-toqubit mapping and reduce the complexity of our algorithm from $O\left(N^{4}\right)$ to $O\left(N^{3}\right)$. Evaluations on various Fermionic systems demonstrate $5 \sim 25 \%$ reduction in Pauli weight, gate count, and circuit depth, alongside excellent scalability to larger systems. Experiments on the Ionq device also show the advantages of HATT in noise resistance in quantum simulations.

Quantum Error Correction (QEC) is essential for fault-tolerant, large-scale quantum computation.However, error drift in qubits undermines QEC performance during long computations, necessitating frequent calibration.Conventional calibration methods disrupt quantum states, requiring system downtime and rendering in situ calibration impractical.To address this challenge, we propose QECali, a novel framework that enables in situ calibration for surface codes.Our evaluation demonstrates that QECali introduces modest qubit overhead and negligible increases in execution time, offering the first practical solution for in situ calibration in surface code based quantum computation.

Quantum Hamiltonian simulation, fundamental in quantum algorithm design, extends far beyond its foundational roots, powering diverse quantum computing applications. However, optimizing the compilation of quantum Hamiltonian simulation poses significant challenges. Existing approaches fall short in reconciling deterministic and randomized compilation, lack appropriate intermediate representations, and struggle to guarantee correctness. Addressing these challenges, we present MarQSim, a novel compilation framework. MarQSim leverages a Markov chain-based approach, encapsulated in the Hamiltonian Term Transition Graph, adeptly reconciling deterministic and randomized compilation benefits. Furthermore, we formulate a Minimum-Cost Flow model that can tune transition matrices to enforce correctness while accommodating various optimization objectives. Experimental results demonstrate MarQSim’s superiority in generating more efficient quantum circuits for simulating various quantum Hamiltonians while maintaining precision.

Designing performant and noise-robust circuits for Quantum Machine Learning (QML) is challenging --- the design space scales exponentially with circuit size, and there are few well-supported guiding principles for QML circuit design. Although recent Quantum Circuit Search (QCS) methods attempt to search for such circuits, they directly adopt designs from classical Neural Architecture Search (NAS) that are misaligned with the unique constraints of quantum hardware, resulting in high search overheads and severe performance bottlenecks.

This paper introduces Fermihedral, a compiler framework focusing on discovering the optimal Fermion-to-qubit encoding for targeted Fermionic Hamiltonians. Fermion-to-qubit encoding is a crucial step in harnessing quantum computing for efficient simulation of Fermionic quantum systems. Utilizing Pauli algebra, Fermihedral redefines complex constraints and objectives of Fermion-to-qubit encoding into a Boolean Satisfiability problem which can then be solved with high-performance solvers. To accommodate larger-scale scenarios, this paper proposed two new strategies that yield approximate optimal solutions mitigating the overhead from the exponentially large number of clauses. Evaluation across diverse Fermionic systems highlights the superiority of Fermihedral, showcasing substantial reductions in implementation costs, gate counts, and circuit depth in the compiled circuits. Real-system experiments on IonQ's device affirm its effectiveness, notably enhancing simulation accuracy.

Bosonic quantum computing, based on the infinite-dimensional qumodes, has shown promise for various practical applications that are classically hard. However, the lack of compiler optimizations has hindered its full potential. This paper introduces Bosehedral, an efficient compiler optimization framework for (Gaussian) Boson sampling on Bosonic quantum hardware. Bosehedral overcomes the challenge of handling infinite-dimensional qumode gate matrices by performing all its program analysis and optimizations at a higher algorithmic level, using a compact unitary matrix representation. It optimizes qumode gate decomposition and logical-to-physical qumode mapping, and introduces a tunable probabilistic gate dropout method. Overall, Bosehedral significantly improves the performance by accurately approximating the original program with much fewer gates. Our evaluation shows that Bosehedral can largely reduce the program size but still maintain a high approximation fidelity, which can translate to significant end-to-end application performance improvement.

In this paper, we introduce Surf-Deformer, a code deformation framework that seamlessly integrates adaptive defect mitigation functionality into the current surface code workflow. It crafts several basic deformation instructions based on fundamental gauge transformations, which can be combined to explore a larger design space than previous methods. This enables more optimized deformation processes tailored to specific defect situations, restoring the QEC capability of deformed codes more efficiently with minimal qubit resources. Additionally, we design an adaptive code layout that accommodates our defect mitigation strategy while ensuring efficient execution of logical operations. Our evaluation shows that Surf-Deformer outperforms previous methods by significantly reducing the end-to-end failure rate of various quantum programs by 35× to 70×, while requiring only about 50% of the qubit resources compared to the previous method to achieve the same level of failure rate. Ablation studies show that Surf-Deformer surpasses previous defect removal methods in preserving QEC capability and facilitates surface code communication by achieving nearly optimal throughnut.

Quantum Computing (QC) is a new computational paradigm that promises significant speedup over classical computing in various domains. However, near-term QC faces numerous challenges, including limited qubit connectivity and noisy quantum operations. To address the qubit connectivity constraint, circuit mapping is required for executing quantum circuits on quantum computers. This process involves performing initial qubit placement and using the quantum SWAP operations to relocate non-adjacent qubits for nearest-neighbor interaction. Reducing the SWAP count in circuit mapping is essential for improving the success rate of quantum circuit execution as SWAPs are costly and error-prone. In this work, we introduce a novel circuit mapping method by combining incremental and parallel solving for Boolean Satisfiability (SAT). We present an innovative SAT encoding for circuit mapping problems, which significantly improves solver-based mapping methods and provides a smooth trade-off between compilation quality and compilation time. Through comprehensive benchmarking of 78 instances covering 3 quantum algorithms on 2 distinct quantum computer topologies, we demonstrate that our method is 26× faster than state-of-the-art solver-based methods, reducing the compilation time from hours to minutes for important quantum applications. Our method also surpasses the existing heuristics algorithm by 26% in SWAP count.

Near-term intermediate-scale quantum (NISQ) devices are subject to considerable noise and short coherence time. Consequently, it is critical to minimize circuit execution latency and improve fidelity. Traditionally, each basis gate of a transpiled circuit is decoded into a fixed episode of the device control pulses. Recent studies investigate the merged pulse generation method for customized gates through quantum optimal control (QOC). In this work, we propose PAQOC, a novel QOC framework that can (i) exploit an augmented program-aware (APA) basis gate set for the tradeoff between compilation time and circuit performance, (ii) prune the search space based on a criticality-centric analytical model and experiment observations we learned from 150 benchmarks. Evaluations using seventeen applications show that PAQOC can achieve an average 54% reduction of the circuit latency, on average 43% reduction in compilation overhead, and a 1.27× improvement in fidelity. PAQOC is available on GitHub1.

Quantum programs are written in high-level languages, whereas quantum hardware can only execute low-level native gates. To run programs on quantum systems, each high- level instruction must be decomposed into native gates. This process is called gate nativization and is performed by the compiler. Recent quantum computers support a richer native gate set to reduce crosstalk by tackling frequency crowding and enable compilers to generate quantum executables with fewer native gates. On these systems, any two-qubit CNOT instruction can be decomposed using more than a single two-qubit native gate. For example, a CNOT can be decomposed using either XY, CPHASE, or CZ native gates on Rigetti machines. Unfortunately, two-qubit native gates have high-error rates and exhibit temporal and spatial variations, which limits the success-rate of quantum programs. Therefore, identifying the native gate that maximizes the success-rate of each CNOT operation in a program is crucial.Our experiments on Rigetti machines show that noise-adaptive gate nativization to select the native gate with the highest fidelity for each CNOT operation is often sub-optimal at the application level. This is because the performance of such nativization heavily depends on the correctness of the device calibration data which only provides the average gate fidelities and may not accurately capture the error trends specific to the qubit state space of a program. Moreover, the calibration data may go stale due to device drifts going undetected. To overcome these limitations, we propose Application-specific Native Gate Selection (ANGEL). ANGEL designs a CopyCat that imitates a given program but has a known solution. Then, ANGEL employs the CopyCat to test different combinations of native gates and learn the optimal combination, which is then used to nativize the given program. To avoid an exponential search, ANGEL uses a divide-and-conquer- based localized search, the complexity of which scales linear with the number of device links used by the program. Our evaluations on Rigetti Aspen-11 show that ANGEL improves the success-rate of programs by 1.40x on average and by up-to 2x.

The quantum simulation kernel is an important subroutine appearing as a very long gate sequence in many quantum programs. In this paper, we propose Paulihedral, a block-wise compiler framework that can deeply optimize this subroutine by exploiting high-level program structure and optimization opportunities. Paulihedral first employs a new Pauli intermediate representation that can maintain the high-level semantics and constraints in quantum simulation kernels. This naturally enables new large-scale optimizations that are hard to implement at the low gate-level. In particular, we propose two technology-independent instruction scheduling passes, and two technology-dependent code optimization passes which reconcile the circuit synthesis, gate cancellation, and qubit mapping stages of the compiler. Experimental results show that Paulihedral can outperform state-of-the-art compiler infrastructures in a wide-range of applications on both near-term superconducting quantum processors and future fault-tolerant quantum computers.

The control of cryogenic qubits in today’s super-conducting quantum computer prototypes presents significant scalability challenges due to the massive costs of generating/routing the analog control signals that need to be sent from a classical controller at room temperature to the quantum chip inside the dilution refrigerator. Thus, researchers in industry and academia have focused on designing in-fridge classical controllers in order to mitigate these challenges. Due to the maturity of CMOS logic, many industrial efforts (Microsoft, Intel) have focused on Cryo-CMOS as a near-term solution to design in-fridge classical controllers. Meanwhile, Supercon-ducting Single Flux Quantum (SFQ) is an alternative, less mature classical logic family proposed for large-scale in-fridge controllers. SFQ logic has the potential to maximize scalability thanks to its ultra-high speed and very low power consumption. However, architecture design for SFQ logic poses challenges due to its unconventional pulse-driven nature and lack of dense memory and logic. Thus, research at the architecture level is essential to guide architects to design SFQ-based classical controllers for large-scale quantum machines.In this paper, we present DigiQ, the first system-level design of a Noisy Intermediate Scale Quantum (NISQ)-friendly SFQ-based classical controller. We perform a design space exploration of SFQ-based controllers and co-design the quantum gate decompositions and SFQ-based implementation of those decompositions to find an optimal SFQ-friendly design point that trades area and power for latency and control while ensuring good quantum algorithmic performance. Our co-design results in a single instruction, multiple data (SIMD) controller architecture, which has high scalability, but imposes new challenges on the calibration of control pulses. We present software-level solutions to address these challenges, which if unaddressed would degrade quantum circuit fidelity given the imperfections of qubit hardware.To validate and characterize DigiQ, we first implement it using hardware description languages and synthesize it using state-of-the-art/validated SFQ synthesis tools. Our synthesis results show that DigiQ can operate within the tight power and area budget of dilution refrigerators at >42,000-qubit scales. Second, we confirm the effectiveness of DigiQ in running quantum algorithms by modeling the execution time and fidelity of a variety of NISQ applications. We hope that the promising results of this paper motivate experimentalists to further explore SFQ-based quantum controllers to realize large-scale quantum machines with maximized scalability.

This paper presents Giallar, a fully-automated verification toolkit for quantum compilers. Giallar requires no manual specifications, invariants, or proofs, and can automatically verify that a compiler pass preserves the semantics of quantum circuits. To deal with unbounded loops in quantum compilers, Giallar abstracts three loop templates, whose loop invariants can be automatically inferred. To efficiently check the equivalence of arbitrary input and output circuits that have complicated matrix semantics representation, Giallar introduces a symbolic representation for quantum circuits and a set of rewrite rules for showing the equivalence of symbolic quantum circuits. With Giallar, we implemented and verified 44 (out of 56) compiler passes in 13 versions of the Qiskit compiler, the open-source quantum compiler standard, during which three bugs were detected in and confirmed by Qiskit. Our evaluation shows that most of Qiskit compiler passes can be automatically verified in seconds and verification imposes only a modest overhead to compilation performance.

Computational chemistry is the leading application to demonstrate the advantage of quantum computing in the near term. However, large-scale simulation of chemical systems on quantum computers is currently hindered due to a mismatch between the computational resource needs of the program and those available in today’s technology. In this paper we argue that significant new optimizations can be discovered by co-designing the application, compiler, and hardware. We show that multiple optimization objectives can be coordinated through the key abstraction layer of Pauli strings, which are the basic building blocks of computational chemistry programs. In particular, we leverage Pauli strings to identify critical program components that can be used to compress program size with minimal loss of accuracy. We also leverage the structure of Pauli string simulation circuits to tailor a novel hardware architecture and compiler, leading to significant execution overhead reduction by up to 99%. While exploiting the high-level domain knowledge reveals significant optimization opportunities, our hardware/software framework is not tied to a particular program instance and can accommodate the full family of computational chemistry problems with such structure. We believe the co-design lessons of this study can be extended to other domains and hardware technologies to hasten the onset of quantum advantage.

Practical error analysis is essential for the design, optimization, and evaluation of Noisy Intermediate-Scale Quantum(NISQ) computing. However, bounding errors in quantum programs is a grand challenge, because the effects of quantum errors depend on exponentially large quantum states. In this work, we present Gleipnir, a novel methodology toward practically computing verified error bounds in quantum programs. Gleipnir introduces the (ρ,δ)-diamond norm, an error metric constrained by a quantum predicate consisting of the approximate state ρ and its distance δ to the ideal state ρ. This predicate (ρ,δ) can be computed adaptively using tensor networks based on the Matrix Product States. Gleipnir features a lightweight logic for reasoning about error bounds in noisy quantum programs, based on the (ρ,δ)-diamond norm metric. Our experimental results show that Gleipnir is able to efficiently generate tight error bounds for real-world quantum programs with 10 to 100 qubits, and can be used to evaluate the error mitigation performance of quantum compiler transformations.

Quantum computers are traditionally operated by programmers at the granularity of a gate-based instruction set. However, the actual device-level control of a quantum computer is performed via analog pulses. We introduce a compiler that exploits direct control at this microarchitectural level to achieve significant improvements for quantum programs. Unlike quantum optimal control, our approach is bootstrapped from existing gate calibrations and the resulting pulses are simple. Our techniques are applicable to any quantum computer and realizable on current devices. We validate our techniques with millions of experimental shots on IBM quantum computers, controlled via the OpenPulse control interface. For representative benchmarks, our pulse control techniques achieve both 1.6x lower error rates and 2x faster execution time, relative to standard gate-based compilation. These improvements are critical in the near-term era of quantum computing, which is bottlenecked by error rates and qubit lifetimes.

Building a quantum computer that surpasses the computational power of its classical counterpart is a great engineering challenge. Quantum software optimizations can provide an accelerated pathway to the first generation of quantum computing (QC) applications that might save years of engineering effort. Current quantum software stacks follow a layered approach similar to the stack of classical computers, which was designed to manage the complexity. In this review, we point out that greater efficiency of QC systems can be achieved by breaking the abstractions between these layers. We review several works along this line, including two hardware-aware compilation optimizations that break the quantum instruction set architecture (ISA) abstraction and two error-correction/information-processing schemes that break the qubit abstraction. Last, we discuss several possible future directions.

Recent developments in engineering and algorithms have made real-world applications in quantum computing possible in the near future. Existing quantum programming languages and compilers use a quantum assembly language composed of 1- and 2-qubit (quantum bit) gates. Quantum compiler frameworks translate this quantum assembly to electric signals (called control pulses) that implement the specified computation on specific physical devices. However, there is a mismatch between the operations defined by the 1- and 2-qubit logical ISA and their underlying physical implementation, so the current practice of directly translating logical instructions into control pulses results in inefficient, high-latency programs. To address this inefficiency, we propose a universal quantum compilation methodology that aggregates multiple logical operations into larger units that manipulate up to 10 qubits at a time. Our methodology then optimizes these aggregates by (1) finding commutative intermediate operations that result in more efficient schedules and (2) creating custom control pulses optimized for the aggregate (instead of individual 1- and 2-qubit operations). Compared to the standard gate-based compilation, the proposed approach realizes a deeper vertical integration of high-level quantum software and low-level, physical quantum hardware. We evaluate our approach on important near-term quantum applications on simulations of superconducting quantum architectures. Our proposed approach provides a mean speedup of $5\times$, with a maximum of $10\times$. Because latency directly affects the feasibility of quantum computation, our results not only improve performance but also have the potential to enable quantum computation sooner than otherwise possible.

Quantum computing is on the cusp of reality with Noisy Intermediate-Scale Quantum (NISQ) machines currently under development and testing. Some of the most promising algorithms for these machines are variational algorithms that employ classical optimization coupled with quantum hardware to evaluate the quality of each candidate solution. Recent work used GRadient Descent Pulse Engineering (GRAPE) to translate quantum programs into highly optimized machine control pulses, resulting in a significant reduction in the execution time of programs. This is critical, as quantum machines can barely support the execution of short programs before failing.