Early diagnosis and intervention are crucial for mild cognitive impairment (MCI), as MCI often progresses to more severe neurodegenerative conditions. In this study, we explore utilizing deep learning for MCI detection without loosing the interpretability provided by feature-based approaches. We used a dataset consisting of 90 MCI patients and 91 controls collected via a remote assessment platform and analyzed the participants' spontaneous speech responses to the Patient Report of Problems (PROP) which asks patients to report their most bothersome general health problems. The proposed deep neural network, which features a bottleneck layer including 13 interpretable symptom domains, achieved an AUC of 0.62, thereby outperforming a set of feature-based classifiers while ensuring interpretability due to the bottleneck layer. We further illustrated the model's interpretability by examining how the predicted PROP domains influence final predictions using Shapley values.

We investigate the feasibility, task compliance and audiovisual data quality of a multimodal dialog-based solution for remote assessment of Amyotrophic Lateral Sclerosis (ALS). 53 people with ALS and 52 healthy controls interacted with Tina, a cloud-based conversational agent, in performing speech tasks designed to probe various aspects of motor speech function while their audio and video was recorded. We rated a total of 250 recordings for audio/video quality and participant task compliance, along with the relative frequency of different issues observed. We observed excellent compliance (98%) and audio (95.2%) and visual quality rates (84.8%), resulting in an overall yield of 80.8% recordings that were both compliant and of high quality. Furthermore, recording quality and compliance were not affected by level of speech severity and did not differ significantly across end devices. These findings support the utility of dialog systems for remote monitoring of speech in ALS.

Abstract We explore the utility of an on-demand multimodal conversational platform in extracting speech and facial metrics in children with Autism Spectrum Disorder (ASD). We investigate the extent to which these metrics correlate with objective clinical measures, particularly as they pertain to the interplay be-tween the affective, phonatory and motoric subsystems. 22 participants diagnosed with ASD engaged with a virtual agent in conversational affect production tasks designed to elicit facial and vocal affect. We found significant correlations between vocal pitch and loudness extracted by our platform during these tasks and accuracy in recognition of facial and vocal affect, as-sessed via the Diagnostic Analysis of Nonverbal Accuracy-2 (DANVA-2) neuropsychological task. We also found significant correlations between jaw kinematic metrics extracted using our platform and motor speed of the dominant hand assessed via a standardised neuropsychological finger tapping task. These findings offer preliminary evidence for the usefulness of these audiovisual analytic metrics and could help us better model the interplay between different physiological subsystems in individuals with ASD.

We propose a cloud-based multimodal dialog platform for the remote assessment and monitoring of Amyotrophic Lateral Sclerosis (ALS) at scale. This paper presents our vision, technology setup, and an initial investigation of the efficacy of the various acoustic and visual speech metrics automatically extracted by the platform. 82 healthy controls and 54 people with ALS (pALS) were instructed to interact with the platform and completed a battery of speaking tasks designed to probe the acoustic, articulatory, phonatory, and respiratory aspects of their speech. We find that multiple acoustic (rate, duration, voicing) and visual (higher order statistics of the jaw and lip) speech metrics show statistically significant differences between controls, bulbar symptomatic and bulbar pre-symptomatic patients. We report on the sensitivity and specificity of these metrics using five-fold cross-validation. We further conducted a LASSO-LARS regression analysis to uncover the relative contributions of various acoustic and visual features in predicting the severity of patients' ALS (as measured by their self-reported ALSFRS-R scores). Our results provide encouraging evidence of the utility of automatically extracted audiovisual analytics for scalable remote patient assessment and monitoring in ALS.

In order to interact with people in a natural way, a robot must be able to link words to objects and actions. Although previous studies in the literature have investigated grounding, they did not consider grounding of unknown synonyms. In this paper, we introduce a probabilistic model for grounding unknown synonymous object and action names using cross-situational learning. The proposed Bayesian learning model uses four different word representations to determine synonymous words. Afterwards, they are grounded through geometric characteristics of objects and kinematic features of the robot joints during action execution. The proposed model is evaluated through an interaction experiment between a human tutor and HSR robot. The results show that semantic and syntactic information both enable grounding of unknown synonyms and that the combination of both achieves the best grounding.

We present NEMSI, a cloud-based multimodal dialog system designed to have naturalistic interactions with individuals for the purpose of screening neurological or mental conditions. The system has been used by thousands of people capturing audio and video responses to open-ended questions and structured health surveys.