The collection of large, complex datasets has become common across a wide variety of domains. Visual analytics tools increasingly play a key role in exploring and answering complex questions about these large datasets. However, many visualizations are not designed to concurrently visualize the large number of dimensions present in complex datasets (e.g. tens of thousands of distinct codes in an electronic health record system). This fact, combined with the ability of many visual analytics systems to enable rapid, ad-hoc specification of groups, or cohorts, of individuals based on a small subset of visualized dimensions, leads to the possibility of introducing selection bias-when the user creates a cohort based on a specified set of dimensions, differences across many other unseen dimensions may also be introduced. These unintended side effects may result in the cohort no longer being representative of the larger population intended to be studied, which can negatively affect the validity of subsequent analyses. We present techniques for selection bias tracking and visualization that can be incorporated into high-dimensional exploratory visual analytics systems, with a focus on medical data with existing data hierarchies. These techniques include: (1) tree-based cohort provenance and visualization, including a user-specified baseline cohort that all other cohorts are compared against, and visual encoding of cohort "drift", which indicates where selection bias may have occurred, and (2) a set of visualizations, including a novel icicle-plot based visualization, to compare in detail the per-dimension differences between the baseline and a user-specified focus cohort. These techniques are integrated into a medical temporal event sequence visual analytics tool. We present example use cases and report findings from domain expert user interviews.

Temporal event data are collected across a broad range of domains, and a variety of visual analytics techniques have been developed to empower analysts working with this form of data. These techniques generally display aggregate statistics computed over sets of event sequences that share common patterns. Such techniques are often hindered, however, by the high-dimensionality of many real-world event sequence datasets which can prevent effective aggregation. A common coping strategy for this challenge is to group event types together prior to visualization, as a pre-process, so that each group can be represented within an analysis as a single event type. However, computing these event groupings as a pre-process also places significant constraints on the analysis. This paper presents a new visual analytics approach for dynamic hierarchical dimension aggregation. The approach leverages a predefined hierarchy of dimensions to computationally quantify the informativeness, with respect to a measure of interest, of alternative levels of grouping within the hierarchy at runtime. This information is then interactively visualized, enabling users to dynamically explore the hierarchy to select the most appropriate level of grouping to use at any individual step within an analysis. Key contributions include an algorithm for interactively determining the most informative set of event groupings for a specific analysis context, and a scented scatter-plus-focus visualization design with an optimization-based layout algorithm that supports interactive hierarchical exploration of alternative event type groupings. We apply these techniques to high-dimensional event sequence data from the medical domain and report findings from domain expert interviews.