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Jyun-Hong Lin

dblp:244/3368 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2022
—ORCID · unresolved

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 3 heaviest of 3, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology
genomics
0.612022
LongPhase: an ultra-fast chromosome-scale phasing algorithm for small and large variants · Bioinform. 2022
Bioinformatics and computational biology › statistical genetics › haplotype analysis
haplotype phasing
0.612022
LongPhase: an ultra-fast chromosome-scale phasing algorithm for small and large variants · Bioinform. 2022
Bioinformatics and computational biology › sequence analysis
long-read sequencing
0.212022
LongPhase: an ultra-fast chromosome-scale phasing algorithm for small and large variants · Bioinform. 2022

Methods — techniques the papers use, named apart from their topics

long-read phasing · 0.6
YearPublicationVenuePosition
2022 LongPhase: an ultra-fast chromosome-scale phasing algorithm for small and large variants
abstract
MOTIVATION: Long-read phasing has been used for reconstructing diploid genomes, improving variant calling and resolving microbial strains in metagenomics. However, the phasing blocks of existing methods are broken by large Structural Variations (SVs), and the efficiency is unsatisfactory for population-scale phasing. RESULTS: This article presents a novel algorithm, LongPhase, which can simultaneously phase single nucleotide polymorphisms (SNPs) and SVs of a human genome in 10-20 min, 10× faster than the state-of-the-art WhatsHap, HapCUT2 and Margin. In particular, co-phasing SNPs and SVs produces much larger haplotype blocks (N50 = 25 Mbp) than those of existing methods (N50 = 10-15 Mbp). We show that LongPhase combined with Nanopore ultra-long reads is a cost-effective and highly contiguous solution, which can produce between one and 26 blocks per chromosome arm without the need for additional trios, chromosome-conformation and strand-seq data. AVAILABILITYAND IMPLEMENTATION: LongPhase is freely available at https://github.com/twolinin/LongPhase/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Jyun-Hong Lin, Liang-Chi Chen, Shu-Chi Yu, Yao-Ting Huang
Bioinform.1