Evidence has accumulated enough to prove non-coding RNAs (ncRNAs) play important roles in cellular biological processes and disease pathogenesis. High throughput techniques have produced a large number of ncRNAs whose function remains unknown. Since the accurate identification of ncRNAs family is helpful to the research of their function, it is of necessity and urgency to predict the family of each ncRNAs. Although several traditional excellent methods are applicable to predict the family of ncRNAs, their complex procedures or inaccurate performance remain major problems confronting us. The main idea of those methods is first to predict the secondary structure, and then identify ncRNAs family according to properties of the secondary structure. Unfortunately, the multi-step error superposition, especially the imperfection of RNA secondary structure prediction tools, maybe the cause of low accuracy. In this paper, a novel end-to-end method 'ncRFP' was proposed to complete the prediction task based on Deep Learning. Instead of predicting the secondary structure, ncRFP predicts the ncRNAs family by automatically extracting features from ncRNAs sequences. Compared with other methods, ncRFP not only simplifies the process but also improves accuracy. The source code of ncRFP can be available at https://github.com/linyuwangPHD/ncRFP.

Nodes performing different functions in a network have different roles, and these roles can be gleaned from the structure of the network. Learning latent representations for the roles of nodes helps to understand the network and to transfer knowledge across networks. However, most existing structural embedding approaches suffer from high computation and space cost or rely on heuristic feature engineering. Here we propose RiWalk, a flexible paradigm for learning structural node representations as it decouples the structural embedding problem into a role identification procedure and a network embedding procedure. Through role identification, rooted kernels with structural dependencies kept are built to better integrate network embedding methods. To demonstrate the effectiveness of RiWalk, we develop two different role identification methods named RiWalk-SP and RiWalk-WL respectively and employ random walk based network embedding methods. Experiments on within-network classification tasks show that our proposed algorithms achieve comparable performance with other baselines while being an order of magnitude more efficient. Besides, we also conduct across-network role classification tasks. The results show potential of structural embeddings in transfer learning. RiWalk is also scalable, making it capable of capturing structural roles in massive networks.