Biological sequences, including RNAs and proteins, share similarities with natural languages, enabling the application of advanced language models to various biological tasks. However, due to its flexibility and lack of experimental data, RNA is a particularly challenging biological ``language'' compared to other biological sequences like proteins. RNA multiple sequence alignments (MSAs), which align evolutionarily related RNA sequences, can greatly enhance RNA biology modeling, as evidenced by their significant roles in structure prediction and function annotation. This raises the question of whether RNA MSAs can also benefit RNA design, which remains unexplored. This paper introduces RMSAGen, a model comprising RMSA-Encoder and RMSA-Decoder, that leverages MSAs to design functional RNA sequences. RMSA-Encoder effectively extracts MSA features, enhancing performance in functional prediction and solvent accessibility prediction tasks and supporting RMSA-Decoder in accurate RNA generation. RMSAGen can design RNA sequences that effectively bind to target RNA-binding proteins, and the design performance improves with an increasing number of sequences. In addition, the ribozymes designed with structural features by RMSAGen show strong computational metrics and exhibit biological activity during gel electrophoresis. These results highlight the effectiveness of RMSAGen, establishing it as a powerful tool and a new direction for RNA design.

Previous work adopts large language models (LLMs) as evaluators to evaluate natural language process (NLP) tasks. However, certain shortcomings, e.g., fairness, scope, and accuracy, persist for current LLM evaluators. To analyze whether LLMs can serve as reliable alternatives to humans, we examine the fine-grained alignment between LLM evaluators and human annotators, particularly in understanding the target evaluation tasks and conducting evaluations that meet diverse criteria. This paper explores both conventional tasks (e.g., story generation) and alignment tasks (e.g., math reasoning), each with different evaluation criteria. Our analysis shows that 1) LLM evaluators can generate unnecessary criteria or omit crucial criteria, resulting in a slight deviation from the experts. 2) LLM evaluators excel in general criteria, such as fluency, but face challenges with complex criteria, such as numerical reasoning. We also find that LLM-pre-drafting before human evaluation can help reduce the impact of human subjectivity and minimize annotation outliers in pure human evaluation, leading to more objective evaluation. All resources are available at https://github.com/qtli/CoEval.

Large language models (LLMs) have significantly benefited from training on diverse, high-quality task-specific data, leading to impressive performance across a range of downstream applications. Current methods often rely on human-annotated data or predefined task templates to direct powerful LLMs in synthesizing task-relevant data for effective model training. However, this dependence on manually designed components may constrain the scope of generated data, potentially overlooking critical edge cases or novel scenarios that could challenge the model. In this paper, we present a novel approach, ReverseGen, designed to automatically generate effective training samples that expose the weaknesses of LLMs. Specifically, we introduce a dedicated proposer trained to produce queries that lead target models to generate unsatisfactory responses. These failure-inducing queries are then used to construct training data, helping to address the models' shortcomings and improve overall performance. Our approach is flexible and can be applied to models of various scales (3B, 7B, and 8B). We evaluate ReverseGen on three key applications—safety, honesty, and math—demonstrating that our generated data is both highly effective and diverse. Models fine-tuned with ReverseGen-generated data consistently outperform those trained on human-annotated or general model-generated data, offering a new perspective on data synthesis for task-specific LLM enhancement.

Model customization necessitates high-quality and diverse datasets, but acquiring such data remains time-consuming and labor-intensive. Despite the great potential of large language models (LLMs) for data synthesis, current approaches are constrained by limited seed data, model biases and low-variation prompts, resulting in limited diversity and biased distribution with the increase of data scales. To tackle this challenge, we introduce TreeSynth, a tree-guided subspace-based data synthesis approach inspired by decision trees. It constructs a spatial partitioning tree to recursively divide a task-specific full data space (i.e., root node) into numerous atomic subspaces (i.e., leaf nodes) with mutually exclusive and exhaustive attributes to ensure both distinctiveness and comprehensiveness, before synthesizing samples within each atomic subspace. This globally divide-and-synthesize method finally collects subspace samples into a comprehensive dataset, effectively circumventing repetition and space collapse to ensure the diversity of large-scale data synthesis. Furthermore, the spatial partitioning tree enables sample allocation into atomic subspaces, allowing the re-balancing of existing datasets for more balanced and comprehensive distributions. Empirically, extensive experiments across diverse benchmarks consistently validates the superior data diversity, model performance, and robust scalability of TreeSynth compared to both human-crafted datasets and peer data synthesis methods, with the average performance gain reaching 10%. Besides, the consistent improvements of TreeSynth-balanced datasets highlight its efficacious application to redistribute existing datasets for more comprehensive coverage and the induced performance enhancement. The code is available at https://github.com/cpa2001/TreeSynth.

Recent research has increasingly focused on reconciling the reasoning capabilities of System 2 with the efficiency of System 1. While existing training-based and prompt-based approaches face significant challenges in terms of efficiency and stability, model merging emerges as a promising strategy to integrate the diverse capabilities of different Large Language Models (LLMs) into a unified model. However, conventional model merging methods often assume uniform importance across layers, overlooking the functional heterogeneity inherent in neural components. To address this limitation, we propose \textbf{A}ctivation-Guided \textbf{C}onsensus \textbf{M}erging (\textbf{ACM}), a plug-and-play merging framework that determines layer-specific merging coefficients based on mutual information between activations of pre-trained and fine-tuned models. ACM effectively preserves task-specific capabilities without requiring gradient computations or additional training. Extensive experiments on Long-to-Short (L2S) and general merging tasks demonstrate that ACM consistently outperforms all baseline methods. For instance, in the case of Qwen-7B models, TIES-Merging equipped with ACM achieves a \textbf{55.3\%} reduction in response length while simultaneously improving reasoning accuracy by \textbf{1.3} points. We submit the code with the paper for reproducibility, and it will be publicly available.

In modern sequential decision-making systems, the construction of an optimal candidate action space is critical to efficient inference. However, existing approaches either rely on manually defined action spaces that lack scalability or utilize unstructured spaces that render exhaustive search computationally prohibitive. In this paper, we propose a novel framework named \textsc{DynaAct} for automatically constructing a compact action space to enhance sequential reasoning in complex problem-solving scenarios. Our method first estimates a proxy for the complete action space by extracting general sketches observed in a corpus covering diverse complex reasoning problems using large language models. We then formulate a submodular function that jointly evaluates candidate actions based on their utility to the current state and their diversity, and employ a greedy algorithm to select an optimal candidate set. Extensive experiments on six diverse standard benchmarks demonstrate that our approach significantly improves overall performance, while maintaining efficient inference without introducing substantial latency. The implementation is available at \url{https://github.com/zhaoxlpku/DynaAct}.

Large language models (LLMs) have achieved impressive performance across various mathematical reasoning benchmarks.However, there are increasing debates regarding whether these models truly understand and apply mathematical knowledge or merely rely on shortcuts for mathematical reasoning.One essential and frequently occurring evidence is that when the math questions are slightly changed, LLMs can behave incorrectly.This motivates us to evaluate the robustness of LLMs' math reasoning capability by testing a wide range of question variations.We introduce the adversarial grade school math (GSM-PLUS) dataset, an extension of GSM8K augmented with various mathematical perturbations.Our experiments on 25 LLMs and 4 prompting techniques show that while LLMs exhibit different levels of math reasoning abilities, their performances are far from robust.In particular, even for problems that have been solved in GSM8K, LLMs can make mistakes when new statements are added or the question targets are altered.We also explore whether more robust performance can be achieved by composing existing prompting methods, in which we try an iterative method that generates and verifies each intermediate thought based on its reasoning goal and calculation result.

Yafu Li, Qintong Li, Leyang Cui, Wei Bi, Zhilin Wang, Longyue Wang, Linyi Yang, Shuming Shi, Yue Zhang. Proceedings of the 62nd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2024.

Chang Ma, Haiteng Zhao, Lin Zheng, Jiayi Xin, Qintong Li, Lijun Wu, Zhihong Deng, Yang Young Lu, Qi Liu, Sheng Wang, Lingpeng Kong. Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing. 2024.

Enhancing low-light images improves both the visibility and quality of the images. Existing methods primarily focus on the enhancement process and heavily rely on the supervised learning strategy , where low/normal-light image pairs are used as the training dataset. In this paper, we propose a novel method called Learn Enhancement by Learning Degradation (LELD) to achieve efficient light adjustment and scene fidelity. We use a carefully designed degradation network (DNet) to guide the enhancement network (ENet). Specifically, the role of DNet is transforming normal-light images into low-light images. For better generalization ability , we employ an unsupervised learning strategy and a generative adversarial network framework. The training is totally dependent on unpaired datasets. Inspired by Retinex theory , we propose a fidelity loss to maintain color and detail during the degradation process . The ENet exhibits a straightforward architecture and achieves efficient enhancement. Experimental results demonstrate the advantages of our method over state-of-the-art methods in terms of visual quality and enhancement efficiency.

When communicating with elders with cognitive impairment, cognitive stimulation (CS) help to maintain the cognitive health of elders.Data sparsity is the main challenge in building CS-based dialogue systems, particularly in the Chinese language.To fill this gap, we construct a Chinese CS conversation (CSConv) dataset, which contains about 2.6K groups of dialogues with therapy principles and emotional support strategy labels.Making chit chat while providing emotional support is overlooked by the majority of existing cognitive dialogue systems.In this paper, we propose a multi-source knowledge fusion method for CS dialogue (CSD), to generate open-ended responses guided by the therapy principle and emotional support strategy.We first use a progressive mask method based on external knowledge to learn encoders as effective classifiers, which is the prerequisite to predict the therapy principle and emotional support strategy of the target response.Then a decoder interacts with the perceived therapy principle and emotional support strategy to generate responses.Extensive experiments conducted on the CSConv dataset demonstrate the effectiveness of the proposed method, while there is still a large space for improvement compared to human performance 1 .

Lack of external knowledge makes empathetic dialogue systems difficult to perceive implicit emotions and learn emotional interactions from limited dialogue history. To address the above problems, we propose to leverage external knowledge, including commonsense knowledge and emotional lexical knowledge, to explicitly understand and express emotions in empathetic dialogue generation. We first enrich the dialogue history by jointly interacting with external knowledge and construct an emotional context graph. Then we learn emotional context representations from the knowledge-enriched emotional context graph and distill emotional signals, which are the prerequisites to predicate emotions expressed in responses. Finally, to generate the empathetic response, we propose an emotional cross-attention mechanism to learn the emotional dependencies from the emotional context graph. Extensive experiments conducted on a benchmark dataset verify the effectiveness of the proposed method. In addition, we find the performance of our method can be further improved by integrating with a pre-trained model that works orthogonally.

There is a growing interest in dataset generation recently due to the superior generative capacity of large pre-trained language models (PLMs).In this paper, we study a flexible and efficient zero-short learning method, ZEROGEN.Given a zero-shot task, we first generate a dataset from scratch using PLMs in an unsupervised manner.Then, we train a tiny task model (e.g., LSTM) under the supervision of the synthesized dataset.This approach allows highly efficient inference as the final task model only has orders of magnitude fewer parameters comparing to PLMs (e.g., GPT2-XL).Apart from being annotation-free and efficient, we argue that ZEROGEN can also provide useful insights from the perspective of datafree model-agnostic knowledge distillation, and unreferenced text generation evaluation.Experiments and analysis on different NLP tasks, namely, text classification, question answering, and natural language inference, show the effectiveness of ZEROGEN.

In e-commerce, opinion tags refer to a ranked list of tags provided by the e-commerce platform that reflect characteristics of reviews of an item. To assist consumers to quickly grasp a large number of reviews about an item, opinion tags are increasingly being applied by e-commerce platforms. Current mechanisms for generating opinion tags rely on either manual labelling or heuristic methods, which is time-consuming and ineffective. In this paper, we propose the abstractive opinion tagging task, where systems have to automatically generate a ranked list of opinion tags that are based on, but need not occur in, a given set of user-generated reviews. The abstractive opinion tagging task comes with three main challenges: the noisy nature of reviews; the formal nature of opinion tags vs. the colloquial language usage in reviews; and the need to distinguish between different items with very similar aspects. To address these challenges, we propose an abstractive opinion tagging framework, named AOT-Net, to generate a ranked list of opinion tags given a large number of reviews. First, a sentence-level salience estimation component estimates each review's salience score. Next, a review clustering and ranking component ranks reviews in two steps: first, reviews are grouped into clusters and ranked by cluster size; then, reviews within each cluster are ranked by their distance to the cluster center. Finally, given the ranked reviews, a rank-aware opinion tagging component incorporates an alignment feature and alignment loss to generate a ranked list of opinion tags. To facilitate the study of this task, we create and release a large-scale dataset, called eComTag, crawled from real-world e-commerce websites. Extensive experiments conducted on the eComTag dataset verify the effectiveness of the proposed AOT-Net in terms of various evaluation metrics.

A humanized dialogue system is expected to generate empathetic replies, which should be sensitive to the users' expressed emotion.The task of empathetic dialogue generation is proposed to address this problem.The essential challenges lie in accurately capturing the nuances of human emotion and considering the potential of user feedback, which are overlooked by the majority of existing work.In response to this problem, we propose a multi-resolution adversarial model -EmpDG, to generate more empathetic responses.EmpDG exploits both the coarse-grained dialogue-level and fine-grained token-level emotions, the latter of which helps to better capture the nuances of user emotion.In addition, we introduce an interactive adversarial learning framework which exploits the user feedback, to identify whether the generated responses evoke emotion perceptivity in dialogues.Experimental results show that the proposed approach significantly outperforms the state-of-the-art baselines in both content quality and emotion perceptivity.