Hyperspectral remote sensing images often suffer from mixed noise-Gaussian, stripe, and impulse-due to atmospheric interference, solar variability, and sensor imperfections. These noises are typically band-dependent and diverse in distribution, making unified denoising particularly challenging. Existing deep denoising methods rely on clean/noisy pairs, which are unavailable in real-world remote sensing, while traditional approaches require manual tuning and lack adaptability. We propose SpecEStop, a fully self-supervised spectral vector denoising framework that requires only a single noisy HSI for training. Leveraging a novel deep spectral prior, SpecEStop exploits the spectral bias of neural networks, which tend to learn low-frequency (clean) signal components with Gaussian noise before overfitting to non-Gaussian noise ones. An adaptive early stopping strategy halts training before non-Gaussian noise is learned, enabling effective suppression of complex noise patterns. To address remaining Gaussian noise, we purposely design the network architecture to preserve its statistical properties in the latent space, allowing the use of off-the-shelf Gaussian denoisers during inference. Without any clean supervision, SpecEStop achieves effective, stage-wise removal of mixed noise, as validated across diverse real-world scenarios. Code will be released at https://github.com/ruobing-Zhang and the permanent code repository maintained by the corresponding author at http://github.com/LinaZhuang.

Electron microscopy (EM) image denoising is critical for visualization and subsequent analysis. Despite the remarkable achievements of deep learning-based non-blind denoising methods, their performance drops significantly when domain shifts exist between the training and testing data. To address this issue, unpaired blind denoising methods have been proposed. However, these methods heavily rely on image-to-image translation and neglect the inherent characteristics of EM images, limiting their overall denoising performance. In this paper, we propose the first unsupervised domain adaptive EM image denoising method, which is grounded in the observation that EM images from similar samples share common content characteristics. Specifically, we first disentangle the content representations and the noise components from noisy images and establish a shared domain-agnostic content space via domain alignment to bridge the synthetic images (source domain) and the real images (target domain). To ensure precise domain alignment, we further incorporate domain regularization by enforcing that: the pseudo-noisy images, reconstructed using both content representations and noise components, accurately capture the characteristics of the noisy images from which the noise components originate, all while maintaining semantic consistency with the noisy images from which the content representations originate. To guarantee lossless representation decomposition and image reconstruction, we introduce disentanglement-reconstruction invertible networks. Finally, the reconstructed pseudo-noisy images, paired with their corresponding clean counterparts, serve as valuable training data for the denoising network. Extensive experiments on synthetic and real EM datasets demonstrate the superiority of our method in terms of image restoration quality and downstream neuron segmentation accuracy. Our code is publicly available at https://github.com/sydeng99/DADn.

Serial section electron microscopy (ssEM) is a pivotal technique for investigating neuronal connections and brain microstructures. However, imperfect sample preparation and image acquisition often lead to degradation, posing challenges for subsequent analysis. While previous deep learning methods, such as the interpolation model using spatially adaptive convolutions, have been proven to outperform conventional approaches, they struggle to recover high-frequency details, resulting in poor perceptual quality and segmentation performance. This study presents a novel approach leveraging diffusion models to restore missing slices of ssEM images. To accommodate the anisotropic characteristic of ssEM images, we enhance the backbone network with asymmetric and symmetric 3D convolutions. Additionally, we propose the Adaptive and Learnable Reconstruction (ALR) module with the First and Last slices Attention Block (FLAB) for effective feature extraction. A Multi-output Joint Strategy (MJS) is utilized for noise estimation, reducing training-testing discrepancies and achieving diffusion correction. Moreover, we also redesign the inference process to optimize the restoration of partially damaged slices, enabling restoration without additional artifact simulation or retraining. Experiment results demonstrate the effectiveness of our approach in generating more realistic slices and its superior performance in downstream tasks, surpassing previous methods.

Accurate 3D neuron segmentation from electron mi-croscopy (EM) volumes is crucial for neuroscience re-search. However, the complex neuron morphology often leads to over-merge and over-segmentation results. Recent advancements utilize 3D CNNs to predict a 3D affinity map with improved accuracy but suffer from two challenges: high computational cost and limited input size, especially for practical deployment for large-scale EM volumes. To address these challenges, we propose a novel method to leverage lightweight 2D CNNs for efficient neuron segmen-tation. Our method employs a 2D Y-shape network to generate two embedding maps from adjacent 2D sections, which are then converted into an affinity map by measuring their embedding distance. While the 2D network better captures pixel dependencies inside sections with larger in-put sizes, it overlooks inter-section dependencies. To over-come this, we introduce a cross-dimension affinity distillation (CAD) strategy that transfers inter-section dependency knowledge from a 3D teacher network to the 2D student network by ensuring consistency between their output affin-ity maps. Additionally, we design a feature grafting in-teraction (FGI) module to enhance knowledge transfer by grafting embedding maps from the 2D student onto those from the 3D teacher. Extensive experiments on multiple EM neuron segmentation datasets, including a newly built one by ourselves, demonstrate that our method achieves supe-rior performance over state-of-the-art methods with only 1/20 inference latency. We release our code and dataset at https://github.com/liuxyll03/CAD.

As the mainstream technique for capturing images of biological specimens at nanometer resolution, electron microscopy (EM) is extremely time-consuming for scanning wide field-of-view (FOV) specimens. In this paper, we investigate a challenging task of large-factor EM image super-resolution (EMSR), which holds great promise for reducing scanning time, relaxing acquisition conditions, and expanding imaging FOV. By exploiting the repetitive structures and volumetric coherence of EM images, we propose the first generative learning-based framework for large-factor EMSR. Specifically, motivated by the predictability ofrepetitive structures and textures in EM images, we first learn a discrete codebook in the latent space to represent highresolution (HR) cell-specific priors and a latent vector indexer to map low-resolution (LR) EM images to their corresponding latent vectors in a generative manner. By incorporating the generative cell-specific priors from HR EM images through a multi-scale prior fusion module, we then deploy multi-image feature alignment and fusion to further exploit the inter-section coherence in the volumetric EM data. Extensive experiments demonstrate that our proposed framework outperforms advanced single-image and video super-resolution methods for 8× and 16× EMSR (i.e., with 64 times and 256 times less data acquired, respectively), achieving superior visual reconstruction quality and down-stream segmentation accuracy on benchmark EM datasets. Code is available at https://github.com/jtshou/GPEMSR.

The delayed feedback is becoming one of the main obstacles in online advertising due to the pervasive deployment of the cost-per-conversion display strategy requesting a real-time conversion rate (CVR) prediction. It makes the observed data contain a large number of fake negatives that temporarily have no feedback but will convert later. Training on such biased data distribution would severely harm the performance of models. Prevailing approaches wait for a set period of time to see if samples convert before training on them, but solutions to guaranteeing data freshness remain under-explored by current research. In this work, we propose Delayed Feed-back modeling via neural Satellite Networks (DFSN for short) for online CVR prediction. It tackles the issue of data freshness to permit adaptive waiting windows. We first assign a long waiting window for our main model to cover most of conversions and greatly reduce fake negatives. Meanwhile, two kinds of satellite models are devised to learn from the latest data, and online transfer learning techniques are utilized to sufficiently exploit their knowledge. With information from satellites, our main model can deal with the issue of data freshness, achieving better performance than previous methods. Extensive experiments on two real-world advertising datasets demonstrate the superiority of our model.

Many researches have been carried out to explore the ultrastructure of organisms at home and abroad, and different algorithms have been used to reconstruct the images of different samples at the nanoscale. Image “matching” and “fusion” are two significant research fields that directly affect the performance of image Mosaic. As image stitching the first and the last step, if there is no correct image matching and fusion algorithm, it is almost impossible to successful image stitching. Image registration is to map one image to another by looking for a space transformation for two images in a set of image data, so that the points corresponding to the same position in the space in the two images correspond one to one, so as to achieve the purpose of information fusion. In this paper, the feature-based image stitching algorithm was used to transform the analysis of the whole image into the analysis of some features of the image, which greatly reduced the calculation amount. Meanwhile, the feature points were further optimized and selected to reduce the mismatching rate, and the electron microscope images of autistic mice were mosaically splicing. In the registration part, this paper adopts the elastic registration method and makes fine adjustments on this basis to obtain more accurate registration results, which will be helpful for the subsequent segmentation of each organizational structure.