Driven by the ultra-high throughput requirements of 6G, wireless communications are migrating to centimeter wave (cmWave) bands to overcome the limitations of current spectral resources. Massive multiple-input multiple-output (MIMO) and orthogonal frequency division multiplexing (OFDM) systems aim to achieve high spectral efficiency in cmWave regimes but are often constrained by the heavy overhead of downlink channel state information (CSI) feedback. This paper proposes a deep learning scheme based on the multi-axis multi-layer perceptron for image processing (MAXIM) architecture for joint semantic CSI feedback and hybrid beamforming in multi-user cmWave MIMO-OFDM systems, which maximizes the downlink sum rate by end-to-end optimization. Specifically, distributed encoders at multiple user equipments (UEs) perform limited CSI feedback, while the decoder at the base station (BS) jointly designs the hybrid beamforming matrices without explicit CSI reconstruction. The uplink transmission is implemented via deep joint source–channel coding (DJSCC) to enhance CSI compression efficiency and noise robustness. Furthermore, considering the high correlation between vertical and horizontal polarization channels in dual-polarized massive MIMO systems, a cross-polarization interaction module is introduced at the UEs to exploit polarization correlations for joint CSI compression. Simulation results demonstrate that the proposed method improves the downlink sum rate under various signal-to-noise ratio (SNR) conditions with a limited number of feedback symbols, validating its robustness and superiority in multi-user dual-polarized cmWave MIMO-OFDM systems.

With the anticipation of sixth-generation (6G) networks escalating, the integrated sensing and communication (ISAC) and millimeter-wave (mmWave) unmanned aerial vehicle (UAV) communications emerge as the key focus areas. This paper presents an innovative approach to ISAC waveform design tailored for mmWave UAV communications. The orthogonal chirp division multiplexing (OCDM), characterized by a brunch of orthogonal chirp signals, is firstly introduced in UAV scenarios to offer dual sensing and communication functionalities.We propose an holistic waveform design which incorporates OCDM with the state-of-the-art mmWave frequency-modulated continuous wave (FMCW) radar. Specifically, one subcarrier in OCDM is chosen as the dedicated sensing signal to facilitate the FMCW processing at the UAV receiver, while the rest of OCDM subcarriers can be used to enhance communication data rate. Such OCDM-FMCW scheme significantly reduces the required hardware complexity, particularly in analog-to-digital converter, which provides an energy-efficient ISAC solution for the resource-constraint UAVs. Simulation results demonstrate the effectiveness and superiority of the proposed scheme. It can surpass traditional methods like OFDM and OTFS, by trading off the sensing performance, communication performance, and hardware complexity.

The Extremely-large Aperture Reconfigurable In-telligent Surface (RIS) stands out as a promising technology for future 6G communications. However, existing far-field or near-field channel models struggle to adapt effectively to channel estimation in the context of Extremely-large Aperture RIS-assisted wireless communication under a hybrid field. To address this challenge, this paper introduces an efficient hybrid-field channel estimation scheme tailored for Extremely-large Aperture RIS-assisted wireless communication. In this scheme, we initially extend the one-dimensional polar coordinate dictionary to a full-dimensional spherical coordinate dictionary to achieve a more uniform distribution of grid points in the spherical coordinate-domain. Subsequently, we propose a hybrid passive/active RIS architecture, utilizing a limited number of Radio Frequency (RF) chains to acquire channel observations. Finally, we introduce a hybrid-field channel estimation scheme designed to estimate both far-field and near-field components. Simulation results demonstrate that the proposed scheme outperforms purely far-field or near-field schemes.

This paper studies the affine frequency division multiplexing (AFDM)-empowered sparse code multiple access (SCMA) system, referred to as AFDM-SCMA, for supporting massive connectivity in high-mobility environments. First, by placing the sparse codewords on the AFDM chirp subcarriers, the input-output (I/O) relation of AFDM-SCMA systems is presented. Next, we delve into the generalized receiver design, chirp rate selection, and error rate performance of the proposed AFDM-SCMA. The proposed AFDM-SCMA is shown to provide a general framework and subsume the existing OFDM-SCMA as a special case. Third, for efficient transceiver design, we further propose a class of sparse codebooks for simplifying the I/O relation, referred to as I/O relation-inspired codebook design in this paper. Building upon these codebooks, we propose a novel iterative detection and decoding scheme with linear minimum mean square error (LMMSE) estimator for both downlink and uplink channels based on orthogonal approximate message passing principles. Our numerical results demonstrate the superiority of the proposed AFDM-SCMA systems over OFDM-SCMA systems in terms of the error rate performance. We show that the proposed receiver can significantly enhance the error rate performance while reducing the detection complexity.

A novel in-contact three-dimensional (3D) measuring device, called MultiCal, is proposed as a convenient, low-cost (less than US$5000), and robust facility for onsite kinematic calibration and online measurement of robot manipulator accuracy. The device has µm-level accuracy and can be easily embedded in robot cells. During the calibration procedure, the robot manipulator first moves automatically to multiple end-effector orientations with its tool center point (TCP) constrained on a fixed point by a 3D displacement measuring device (single point constraint), and the corresponding joint angles are recorded. Then, the measuring device is precisely mounted at different positions using a well-designed fixture, and the above measurement process is repeated to implement a multi-point constraint. The relative mounting positions are accurately measured and used as prior information to improve calibration accuracy and robustness. The results of theoretical analysis indicate that MultiCal reduces calibration accuracy by 10% to 20% in contrast to traditional non-contact 3D or six-dimensional (6D) measuring devices (such as laser trackers) when subject to the same level of artificial measurement noise. The results of a calibration experiment conducted on a Staubli TX90 robot show that MultiCal has only 7% to 14% lower calibration accuracy compared to a measuring arm with a laser scanner, and 21% to 30% lower time efficiency compared to a 6D binocular vision measuring system, yielding maximum and mean absolute position errors of 0.831 mm and 0.339 mm, respectively.

Integrated sensing and communication (ISAC) has opened up numerous game-changing opportunities for realizing future wireless systems. In this paper, we propose an ISAC processing framework relying on millimeter-wave (mmWave) massive multiple-input multiple-output (MIMO) systems. Specifically, we provide a compressed sampling (CS) perspective to facilitate ISAC processing, which can not only recover the high-dimensional channel state information or/and radar imaging information, but also significantly reduce pilot overhead. First, an energy-efficient widely spaced array (WSA) architecture is tailored for the radar receiver, which enhances the angular resolution of radar sensing at the cost of angular ambiguity. Then, we propose an ISAC frame structure for time-varying ISAC systems considering different timescales. The pilot waveforms are judiciously designed by taking into account both CS theories and hardware constraints induced by hybrid beamforming (HBF) architecture. Next, we design the dedicated dictionary for WSA that serves as a building block for formulating the ISAC processing as sparse signal recovery problems. The orthogonal matching pursuit with support refinement (OMP-SR) algorithm is proposed to effectively solve the problems in the existence of the angular ambiguity. We also provide a framework for estimating the Doppler frequencies during payload data transmission to guarantee communication performances. Simulation results demonstrate the good performances of both communications and radar sensing under the proposed ISAC framework.

In this paper, we study the application of integrated sensing and communication (ISAC) to unmanned aerial vehicle (UAV) networks aided by millimeter-wave (mmWave) massive multiple-input multiple-output (mMIMO). To reduce the pilot overhead for joint channel estimation (CE) and radar sensing, the state-of-the-art compressive sensing (CS) is applied to ISAC processing in UAV networks. Specifically, we proposed a full duplex terrestrial station architecture with hybrid beamforming (HBF), which can simultaneously communicates with UAVs and senses the surrounding environment to avoid UAV collisions. Given that the switch of phase shifter will take non-negligible reconfiguring time in HBF architecture, we propose a pilot waveform design which takes into account both CS theories and hardware constraints. We also design the mixed-resolution (MR) dictionaries that serve as the building block for formulating the joint CE and radar sensing as sparse signal recovery problems. On this basis, the MR orthogonal matching pursuit (MR-OMP) algorithm is utilized to effectively solve the problems. Simulation results demonstrate the good performances of both CE and radar sensing under the proposed ISAC framework.

MOTIVATION: In the process of discovery and optimization of lead compounds, it is difficult for non-expert pharmacologists to intuitively determine the contribution of substructure to a particular property of a molecule. RESULTS: In this work, we develop a user-friendly web service, named interpretable-absorption, distribution, metabolism, excretion and toxicity (ADMET), which predict 59 ADMET-associated properties using 90 qualitative classification models and 28 quantitative regression models based on graph convolutional neural network and graph attention network algorithms. In interpretable-ADMET, there are 250 729 entries associated with 59 kinds of ADMET-associated properties for 80 167 chemical compounds. In addition to making predictions, interpretable-ADMET provides interpretation models based on gradient-weighted class activation map for identifying the substructure, which is important to the particular property. Interpretable-ADMET also provides an optimize module to automatically generate a set of novel virtual candidates based on matched molecular pair rules. We believe that interpretable-ADMET could serve as a useful tool for lead optimization in drug discovery. AVAILABILITY AND IMPLEMENTATION: Interpretable-ADMET is available at http://cadd.pharmacy.nankai.edu.cn/interpretableadmet/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

We propose a holographic version of a reconfigurable intelligent surface (RIS) and investigate its application to terahertz (THz) massive multiple-input multiple-output systems. Capitalizing on the miniaturization of THz electronic components, RISs can be implemented by densely packing sub-wavelength unit cells, so as to realize continuous or quasi-continuous apertures and to enable holographic communications. In this paper, in particular, we derive the beam pattern of a holographic RIS. Our analysis reveals that the beam pattern of an ideal holographic RIS can be well approximated by that of an ultra-dense RIS, which has a more practical hardware architecture. In addition, we propose a closed-loop channel estimation (CE) scheme to effectively estimate the broadband channels that characterize THz massive MIMO systems aided by holographic RISs. The proposed CE scheme includes a downlink coarse CE stage and an uplink finer-grained CE stage. The uplink pilot signals are judiciously designed for obtaining good CE performance. Moreover, to reduce the pilot overhead, we introduce a compressive sensing-based CE algorithm, which exploits the dual sparsity of THz MIMO channels in both the angular domain and delay domain. Simulation results demonstrate the superiority of holographic RISs over the non-holographic ones, and the effectiveness of the proposed CE scheme.

This paper investigates the broadband channel estimation (CE) for intelligent reflecting surface (IRS)-aided millimeter-wave (mmWave) massive MIMO systems. The CE for such systems is a challenging task due to the large dimension of both the active massive MIMO at the base station (BS) and passive IRS. To address this problem, this paper proposes a compressive sensing (CS)-based CE solution for IRS-aided mmWave massive MIMO systems, whereby the angular channel sparsity of large-scale array at mmWave is exploited for improved CE with reduced pilot overhead. Specifically, we first propose a downlink pilot transmission framework. By designing the pilot signals based on the prior knowledge that the line-of-sight dominated BS-to-IRS channel is known, the high-dimensional channels for BS-to-user and IRS-to-user can be jointly estimated based on CS theory. Moreover, to efficiently estimate broadband channels, a distributed orthogonal matching pursuit algorithm is exploited, where the common sparsity shared by the channels at different subcarriers is utilized. Additionally, the redundant dictionary to combat the power leakage is also designed for the enhanced CE performance. Simulation results demonstrate the effectiveness of the proposed scheme.