Cardiac Diffusion Tensor Imaging (cDTI) provides unique insights into myocardial microstructure in-vivo but requires averaging multiple repetitions for adequate signal quality, leading to prohibitively long acquisition times. Standard acceleration strategies, such as reducing repetitions and employing simultaneous multi-slice (SMS) imaging, are limited by low signal-to-noise ratio (SNR) and inter-slice leakage artefacts, respectively. We introduce ORCAS, a unified framework that synergistically combines a novel variable CAIPIRINHA acquisition with an artefact-aware AI reconstruction to overcome these challenges. The variable CAIPIRINHA scheme decoheres SMS artefacts across repetitions, while our dual-domain deep learning model simultaneously suppresses these artefacts and combats the low SNR from fewer repetitions. The model is guided by patient-specific single-band auxiliary data to preserve anatomical fidelity. Validated on ex-vivo hearts with and without anomalies, ORCAS achieves an over 18-fold acceleration by combining these strategies, reducing a whole-heart scan from over two hours to under 7 min. This is accomplished while reducing errors in key biomarkers, such as Fractional Anisotropy, by up to 64%. The framework preserves essential microstructural properties and the delineation of abnormalities, representing a significant step towards the clinical translation of whole-heart cDTI. • Novel variable CAIPIRINHA reduces SMS artefacts in cardiac DTI. • AI framework achieves 18×acceleration while preserving biomarkers. • Reduces DTI errors by 64% compared to conventional reconstruction. • Enables whole-heart cDTI in under 7 min vs over 2 h. • Preserves abnormalities even at extreme acceleration factors.

MOTIVATION: Copy number alterations are driving forces of tumour development and the emergence of intra-tumour heterogeneity. A comprehensive picture of these genomic aberrations is therefore essential for the development of personalised and precise cancer diagnostics and therapies. Single-cell sequencing offers the highest resolution for copy number profiling down to the level of individual cells. Recent high-throughput protocols allow for the processing of hundreds of cells through shallow whole-genome DNA sequencing. The resulting low read-depth data poses substantial statistical and computational challenges to the identification of copy number alterations. RESULTS: We developed SCICoNE, a statistical model and MCMC algorithm tailored to single-cell copy number profiling from shallow whole-genome DNA sequencing data. SCICoNE reconstructs the history of copy number events in the tumour and uses these evolutionary relationships to identify the copy number profiles of the individual cells. We show the accuracy of this approach in evaluations on simulated data and demonstrate its practicability in applications to two breast cancer samples from different sequencing protocols. AVAILABILITY AND IMPLEMENTATION: SCICoNE is available at https://github.com/cbg-ethz/SCICoNE.

Diffusion tensor cardiovascular magnetic resonance (DTCMR) is the only non-invasive method for visualizing myocardial microstructure, but it is challenged by inconsistent breath-holds and imperfect cardiac triggering, causing in-plane shifts and through-plane warping with an inadequate tensor fitting. While rigid registration corrects in-plane shifts, deformable registration risks distorting the diffusion distribution, and selecting a reference frame among low SNR frames is challenging. Existing pairwise deep learning and iterative methods are unsuitable for DTCMR due to their inability to handle the drastic in-plane motion and disentangle the diffusion contrast distortion with through-plane motions on low SNR frames, which compromises the accuracy of clinical biomarker tensor estimation. Our study introduces a novel deep learning framework incorporating tensor information for groupwise deformable registration, effectively correcting intra-subject inter-frame motion. This framework features a cascaded registration branch for addressing in-plane and through-plane motions and a parallel branch for generating pseudo-frames with diffusion contrasts and template updates to guide registration with a refined loss function and denoising. We evaluated our method on four DTCMR-specific metrics using data from over 900 cases from 2012 to 2023. Our method outperformed three traditional and two deep learning-based methods, achieving reduced fitting errors, the lowest percentage of negative eigenvalues at 0.446%, the highest R2 of HA line profiles at 0.911, no negative Jacobian Determinant, and the shortest reference time of 0.06 seconds per case. In conclusion, our deep learning framework significantly improves DTCMR imaging by effectively correcting inter-frame motion and surpassing existing methods across multiple metrics, demonstrating substantial clinical potential.

The Internet of Vehicles (IoV) is the future of transportation. It will be present everywhere and will have a huge impact on our lives. However, there are plenty of aspects to consider while studying these networks, such as data dissemination, cybersecurity threats and vulnerabilities. For an IoV to work efficiently, data needs to spread through it efficiently. However, the dynamics of vehicular environments due to frequent node mobility and nodes' misbehavior poses many challenges to efficient data dissemination. Therefore, a deep learning-based monitoring system that is capable of detecting anomalies in the network and identifying known misbehavior is proposed. Performance evaluation shows that the monitoring system can identify well-known attacks with a very high success rate. Besides, the algorithm is also capable of detecting other types of misbehavior without labeling them.

The Internet of Vehicles (IoV) is undoubtedly at the core of the future of intelligent transportation. It will prevail over the road ecosystem, and it will have a huge impact on our lives throughout the provision of seamless connectivity among diverse transportation means. For the network to operate efficiently, the data needs to be quickly spread throughout the network, which requires low computational and bandwidth overheads. However, the dynamics of vehicular environments due to frequent node mobility poses many challenges to realize efficient data dissemination. This work addresses this type of problem by proposing a novel clustering algorithm at the edge of the network and an efficient message routing approach, which is known as Group’n Route (GnR). Both mechanisms resort to machine learning and graph metrics that reflect the social relationships between the nodes. Our performance evaluation reveals that the clustering algorithm yields stable results with varying road scenarios, which are becoming an advisable approach in the presence of mobile IoV nodes. Also, the designed routing protocol achieves two orders of magnitude smaller overhead and almost double the delivery rate when it is compared to traditional routing protocols, which thereby justify that the combination of our two proposed clustering and routing methods are a plausible alternative to support IoV communications in real-world setups.