Electrocardiogram (ECG) is widely used to diagnose cardiac conditions via deep learning methods. Although existing self-supervised learning (SSL) methods have achieved great performance in learning representation for ECG-based cardiac conditions classification, the clinical semantics can not be effectively captured. To overcome this limitation, we proposed to learn cross-modal ECG representations that contain more clinical semantics via a novel framework with \textbf{D}eep \textbf{E}CG-\textbf{R}eport \textbf{I}nteraction (\textbf{DERI}). Specifically, we design a novel framework combining multiple alignments and mutual feature reconstructions to learn effective representation of the ECG with the clinical report, which fuses the clinical semantics of the report. An RME-Module inspired by masked modeling is proposed to improve the ECG representation learning. Furthermore, we extend ECG representation learning to report generation with a language model, which is significant for evaluating clinical semantics in the learned representations and even clinical applications. Comprehensive experiments with various settings are conducted on various datasets to show the superior performance of our DERI. Our code is released on https://github.com/cccccj-03/DERI.

Single-cell RNA sequencing (scRNA-seq) experiments have become instrumental in developmental and differentiation studies, enabling the profiling of cells at a single or multiple time-points to uncover subtle variations in expression profiles reflecting underlying biological processes. Benchmarking studies have compared many of the computational methods used to reconstruct cellular dynamics; however, researchers still encounter challenges in their analysis due to uncertainty with respect to selecting the most appropriate methods and parameters. Even among universal data processing steps used by trajectory inference methods such as feature selection and dimension reduction, trajectory methods' performances are highly dataset-specific. To address these challenges, we developed Escort, a novel framework for evaluating a dataset's suitability for trajectory inference and quantifying trajectory properties influenced by analysis decisions. Escort evaluates the suitability of trajectory analysis and the combined effects of processing choices using trajectory-specific metrics. Escort navigates single-cell trajectory analysis through these data-driven assessments, reducing uncertainty and much of the decision burden inherent to trajectory inference analyses. Escort is implemented in an accessible R package and R/Shiny application, providing researchers with the necessary tools to make informed decisions during trajectory analysis and enabling new insights into dynamic biological processes at single-cell resolution.

Intelligent reflecting surface (IRS) is a promising technology to assist downlink information transmissions from a multi-antenna access point (AP) to a receiver. In this paper, we minimize the AP's transmit power by a joint optimization of the AP's active beamforming and the IRS's passive beamforming. Due to uncertain channel conditions, we formulate a robust power minimization problem subject to the receiver's signal-to-noise ratio (SNR) requirement and the IRS's power budget constraint. We propose a deep reinforcement learning (DRL) approach that can adapt the beamforming strategies from past experiences. To improve the learning performance, we derive a convex approximation as a lower bound on the robust problem, which is integrated with the DRL framework and thus promoting a novel optimization-driven deep deterministic policy gradient (DDPG) approach. In particular, when the DDPG algorithm generates a part of the action (e.g., passive beamforming), we can use the model-based convex approximation to optimize the other part of the action (e.g., active beamforming) efficiently. Our simulation results demonstrate that the optimization-driven DDPG algorithm can improve both the learning rate and reward significantly compared to the conventional DDPG algorithm.