Analysing large numbers of brain samples can reveal minor, but statistically and biologically relevant variations in brain morphology that provide critical insights into animal behaviour, ecology and evolution. So far, however, such analyses have required extensive manual effort, which considerably limits the scope for comparative research. Here we used micro-CT imaging and deep learning to perform automated analyses of 3D image data from 187 honey bee and bumblebee brains. We revealed strong inter-individual variations in total brain size that are consistent across colonies and species, and may underpin behavioural variability central to complex social organisations. In addition, the bumblebee dataset showed a significant level of lateralization in optic and antennal lobes, providing a potential explanation for reported variations in visual and olfactory learning. Our fast, robust and user-friendly approach holds considerable promises for carrying out large-scale quantitative neuroanatomical comparisons across a wider range of animals. Ultimately, this will help address fundamental unresolved questions related to the evolution of animal brains and cognition.

Like many other types of cancer, colorectal cancer (CRC) develops through multiple pathways of carcinogenesis. This is also true for colorectal carcinogenesis in Lynch syndrome (LS), the most common inherited CRC syndrome. However, a comprehensive understanding of the distribution of these pathways of carcinogenesis, which allows for tailored clinical treatment and even prevention, is still lacking. We suggest a linear dynamical system modeling the evolution of different pathways of colorectal carcinogenesis based on the involved driver mutations. The model consists of different components accounting for independent and dependent mutational processes. We define the driver gene mutation graphs and combine them using the Cartesian graph product. This leads to matrix components built by the Kronecker sum and product of the adjacency matrices of the gene mutation graphs enabling a thorough mathematical analysis and medical interpretation. Using the Kronecker structure, we developed a mathematical model which we applied exemplarily to the three pathways of colorectal carcinogenesis in LS. Beside a pathogenic germline variant in one of the DNA mismatch repair (MMR) genes, driver mutations in APC, CTNNB1, KRAS and TP53 are considered. We exemplarily incorporate mutational dependencies, such as increased point mutation rates after MMR deficiency, and based on recent experimental data, biallelic somatic CTNNB1 mutations as common drivers of LS-associated CRCs. With the model and parameter choice, we obtained simulation results that are in concordance with clinical observations. These include the evolution of MMR-deficient crypts as early precursors in LS carcinogenesis and the influence of variants in MMR genes thereon. The proportions of MMR-deficient and MMR-proficient APC-inactivated crypts as first measure for the distribution among the pathways in LS-associated colorectal carcinogenesis are compatible with clinical observations. The approach provides a modular framework for modeling multiple pathways of carcinogenesis yielding promising results in concordance with clinical observations in LS CRCs.

Characterizing compute kernel execution behavior on GPUs for efficient task scheduling is a non-trivial task. We address this with a simple model enabling portable and fast predictions among different GPUs using only hardware-independent features. This model is built based on random forests using 189 individual compute kernels from benchmarks such as Parboil, Rodinia, Polybench-GPU, and SHOC. Evaluation of the model performance using cross-validation yields a median Mean Average Percentage Error (MAPE) of 8.86–52.0% for time and 1.84–2.94% for power prediction across five different GPUs, while latency for a single prediction varies between 15 and 108 ms.

There are two types of ordinary differential equations (ODEs): initial value problems (IVPs) and boundary value problems (BVPs). While many probabilistic numerical methods for the solution of IVPs have been presented to-date, there exists no efficient probabilistic general-purpose solver for nonlinear BVPs. Our method based on iterated Gaussian process (GP) regression returns a GP posterior over the solution of nonlinear ODEs, which provides a meaningful error estimation via its predictive posterior standard deviation. Our solver is fast (typically of quadratic convergence rate) and the theory of convergence can be transferred from prior non-probabilistic work. Our method performs on par with standard codes for an established benchmark of test problems.

SUMMARY In the last few years, the landscape of parallel computing has been subject to profound and highly dynamic changes. The paradigm shift towards multicore and manycore technologies coupled with accelerators in a heterogeneous environment is offering a great potential of computing power for scientific and industrial applications. However, for one to take full advantage of these new technologies, holistic approaches coupling the expertise ranging from hardware architecture and software design to numerical algorithms are a pressing necessity. Parallel computing is no longer limited to supercomputers and is now much more diversified – with a multitude of technologies, architectures, and programming approaches leading to increased complexity for developers and engineers. In this work, we give – from the perspective of numerical simulation and applications – an overview of existing and emerging multicore and manycore technologies as well as accelerator concepts. We emphasize the challenges associated with high‐performance heterogeneous computing and discuss the interfaces needed to fill the gap between the hardware architecture and the implementation of efficient numerical algorithms. By means of this short survey – which stresses the necessity of hardware‐aware computing – we aim at giving assistance to users in scientific computing entering this fascinating field and help understanding associated issues and capabilities. Copyright © 2011 John Wiley & Sons, Ltd.

As hardware devices like processor cores and memory sub-systems based on nano-scale technology nodes become more unreliable, the need for fault tolerant numerical computing engines, as used in many critical applications with long computation/mission times, is becoming pronounced. In this paper, we present an Algorithm-based Fault Tolerance (ABFT) scheme for an iterative linear solver engine based on the Conjugated Gradient method (CG) by taking the advantage of numerical defect correction. This method is "pay as you go", meaning that there is practically only a runtime overhead if errors occur and a correction is performed. Our experimental comparison with software-based Triple Modular Redundancy (TMR) clearly shows the runtime benefit of the proposed approach, good fault tolerance and no occurrence of silent data corruption.