Humans have a strong class-agnostic object segmentation ability and can outline boundaries of unknown objects precisely, which motivates us to propose a box-supervised class-agnostic object segmentation (BoxCaseg) based solution for weakly-supervised instance segmentation. The BoxCaseg model is jointly trained using box-supervised images and salient images in a multi-task learning manner. The fine-annotated salient images provide class-agnostic and precise object localization guidance for box-supervised images. The object masks predicted by a pretrained BoxCaseg model are refined via a novel merged and dropped strategy as proxy ground truth to train a Mask R-CNN for weakly-supervised instance segmentation. Only using 7991 salient images, the weakly-supervised Mask R-CNN is on par with fully-supervised Mask R-CNN on PASCAL VOC and significantly outperforms previous state-of-the-art box-supervised instance segmentation methods on COCO. The source code, pretrained models and datasets are available at https://github.com/hustvl/BoxCaseg.

Accurate and rapid diagnosis of COVID-19 suspected cases plays a crucial role in timely quarantine and medical treatment. Developing a deep learning-based model for automatic COVID-19 diagnosis on chest CT is helpful to counter the outbreak of SARS-CoV-2. A weakly-supervised deep learning framework was developed using 3D CT volumes for COVID-19 classification and lesion localization. For each patient, the lung region was segmented using a pre-trained UNet; then the segmented 3D lung region was fed into a 3D deep neural network to predict the probability of COVID-19 infectious; the COVID-19 lesions are localized by combining the activation regions in the classification network and the unsupervised connected components. 499 CT volumes were used for training and 131 CT volumes were used for testing. Our algorithm obtained 0.959 ROC AUC and 0.976 PR AUC. When using a probability threshold of 0.5 to classify COVID-positive and COVID-negative, the algorithm obtained an accuracy of 0.901, a positive predictive value of 0.840 and a very high negative predictive value of 0.982. The algorithm took only 1.93 seconds to process a single patient's CT volume using a dedicated GPU. Our weakly-supervised deep learning model can accurately predict the COVID-19 infectious probability and discover lesion regions in chest CT without the need for annotating the lesions for training. The easily-trained and high-performance deep learning algorithm provides a fast way to identify COVID-19 patients, which is beneficial to control the outbreak of SARS-CoV-2. The developed deep learning software is available at https://github.com/sydney0zq/covid-19-detection.