GPUs have emerged as foundational platforms for high-performance computing and machine learning. However, rapid architectural evolution challenges existing performance evaluations. Cycle-accurate simulation offers high precision but is prohibitively slow for large-scale design exploration. Sampling-based acceleration techniques struggle with behavior characterization, stable-state detection, and execution time prediction, thus constraining their applicability in complex GPU workloads.

Positron Emission Tomography (PET) images reflect the metabolic rate of tracers in different tissues of the human body, crucial for early cancer diagnosis and treatment. Accurate tumor segmentation is essential to aid clinicians in determining drug dosages. Due to the low resolution of PET images, prior information (such as CT, MRI or distance information) are often incorporated to assist PET segmentation. In this paper, we propose an automatic 3D PET tumor segmentation framework assisted by geodesic sequences. Specifically, considering the intrinsic characteristics of PET images, we first construct geodesic prior, which effectively enhances the contrast between the tumor and background while suppressing noise and the influence of other tissues. To address the need for seed points in the geodesic prior, an automatic marking strategy is designed that identifies all suspected lesion regions and uses their central points as a series of seeds to generate the corresponding geodesic sequences. Subsequently, we develop a three-branch network architecture to simultaneously process PET images, geodesic sequences, and background geodesic information. To enhance image features, a distance attention mechanism is introduced at the end of the network encoder to effectively measure the similarity between different geodesic features, refining the image features. Finally, the network incorporates spatial regularization and local PET intensity information into the activation function via the Soft Threshold Dynamics with Local Intensity Fitting (STDLIF) module, further improving segmentation accuracy. Experimental results demonstrate that, compared to existing state-of-the-art algorithms, the proposed method shows better segmentation performance on both clinical and public datasets.

Fast PET imaging is clinically important for reducing motion artifacts and improving patient comfort. While recent diffusion-based deep learning methods have shown promise, they often fail to capture the true PET degradation process, suffer from accumulated inference errors, introduce artifacts, and require extensive reconstruction iterations. To address these challenges, we propose a novel multistage diffusion framework tailored for fast PET imaging. At the coarse level, we design a multistage structure to approximate the temporal non-linear PET degradation process in a data-driven manner, using paired PET images collected under different acquisition duration. A Phase Error Correction Network (PECNet) ensures consistency across stages by correcting accumulated deviations. At the fine level, we introduce a deterministic cold diffusion mechanism, which simulates intra-stage degradation through interpolation between known acquisition durations—significantly reducing reconstruction iterations to as few as 10. Evaluations on [68Ga]FAPI and [18F]FDG PET datasets demonstrate the superiority of our approach, achieving peak PSNRs of 36.2 dB and 39.0 dB, respectively, with average SSIMs over 0.97. Our framework offers high-fidelity PET imaging with fewer iterations, making it practical for accelerated clinical imaging.

The precise segmentation of different brain regions and tissues is usually a prerequisite for the detection and diagnosis of various neurological disorders in neuroscience. Considering the abundance of functional and structural dual-modality information for positron emission tomography/magnetic resonance (PET/MR) images, we propose a novel 3D whole-brain segmentation network with a cross-fusion mechanism introduced to obtain 45 brain regions. Specifically, the network processes PET and MR images simultaneously, employing UX-Net and a cross-fusion block for feature extraction and fusion in the encoder. We test our method by comparing it with other deep learning-based methods, including 3DUXNET, SwinUNETR, UNETR, nnFormer, UNet3D, NestedUNet, ResUNet, and VNet. The experimental results demonstrate that the proposed method achieves better segmentation performance in terms of both visual and quantitative evaluation metrics and achieves more precise segmentation in three views while preserving fine details. In particular, the proposed method achieves superior quantitative results, with a Dice coefficient of 85.73% 0.01%, a Jaccard index of 76.68% 0.02%, a sensitivity of 85.00% 0.01%, a precision of 83.26% 0.03% and a Hausdorff distance (HD) of 4.4885 14.85%. Moreover, the distribution and correlation of the SUV in the volume of interest (VOI) are also evaluated (PCC > 0.9), indicating consistency with the ground truth and the superiority of the proposed method. In future work, we will utilize our whole-brain segmentation method in clinical practice to assist doctors in accurately diagnosing and treating brain diseases.

Positron emission tomography/magnetic resonance imaging (PET/MRI) systems can provide precise anatomical and functional information with exceptional sensitivity and accuracy for neurological disorder detection. Nevertheless, the radiation exposure risks and economic costs of radiopharmaceuticals may pose significant burdens on patients. To mitigate image quality degradation during low-dose PET imaging, we proposed a novel 3D network equipped with a spatial brain transform (SBF) module for low-dose whole-brain PET and MR images to synthesize high-quality PET images. The FreeSurfer toolkit was applied to derive the spatial brain anatomical alignment information, which was then fused with low-dose PET and MR features through the SBF module. Moreover, several deep learning methods were employed as comparison measures to evaluate the model performance, with the peak signal-to-noise ratio (PSNR), structural similarity (SSIM) and Pearson correlation coefficient (PCC) serving as quantitative metrics. Both the visual results and quantitative results illustrated the effectiveness of our approach. The obtained PSNR and SSIM were 41.96 ± 4.91 dB (p < 0.01) and 0.9654 ± 0.0215 (p < 0.01), which achieved a 19% and 20% improvement, respectively, compared to the original low-dose brain PET images. The volume of interest (VOI) analysis of brain regions such as the left thalamus (PCC = 0.959) also showed that the proposed method could achieve a more accurate standardized uptake value (SUV) distribution while preserving the details of brain structures. In future works, we hope to apply our method to other multimodal systems, such as PET/CT, to assist clinical brain disease diagnosis and treatment.

Nasopharyngeal carcinoma (NPC) is a malignant tumor primarily treated by radiotherapy. Accurate delineation of the target tumor is essential for improving the effectiveness of radiotherapy. However, the segmentation performance of current models is unsatisfactory due to poor boundaries, large-scale tumor volume variation, and the labor-intensive nature of manual delineation for radiotherapy. In this paper, MMCA-Net, a novel segmentation network for NPC using PET/CT images that incorporates an innovative multimodal cross attention transformer (MCA-Transformer) and a modified U-Net architecture, is introduced to enhance modal fusion by leveraging cross-attention mechanisms between CT and PET data. Our method, tested against ten algorithms via fivefold cross-validation on samples from Sun Yat-sen University Cancer Center and the public HECKTOR dataset, consistently topped all four evaluation metrics with average Dice similarity coefficients of 0.815 and 0.7944, respectively. Furthermore, ablation experiments were conducted to demonstrate the superiority of our method over multiple baseline and variant techniques. The proposed method has promising potential for application in other tasks.

The short frames of low-count positron emission tomography (PET) images generally cause high levels of statistical noise. Thus, improving the quality of low-count images by using image postprocessing algorithms to achieve better clinical diagnoses has attracted widespread attention in the medical imaging community. Most existing deep learning-based low-count PET image enhancement methods have achieved satisfying results, however, few of them focus on denoising low-count PET images with the magnetic resonance (MR) image modality as guidance. The prior context features contained in MR images can provide abundant and complementary information for single low-count PET image denoising, especially in ultralow-count (2.5%) cases. To this end, we propose a novel two-stream dual PET/MR cross-modal interactive fusion network with an optical flow pre-alignment module, namely, OIF-Net. Specifically, the learnable optical flow registration module enables the spatial manipulation of MR imaging inputs within the network without any extra training supervision. Registered MR images fundamentally solve the problem of feature misalignment in the multimodal fusion stage, which greatly benefits the subsequent denoising process. In addition, we design a spatial-channel feature enhancement module (SC-FEM) that considers the interactive impacts of multiple modalities and provides additional information flexibility in both the spatial and channel dimensions. Furthermore, instead of simply concatenating two extracted features from these two modalities as an intermediate fusion method, the proposed cross-modal feature fusion module (CM-FFM) adopts cross-attention at multiple feature levels and greatly improves the two modalities' feature fusion procedure. Extensive experimental assessments conducted on real clinical datasets, as well as an independent clinical testing dataset, demonstrate that the proposed OIF-Net outperforms the state-of-the-art methods.

Dose reduction in computed tomography (CT) has gained considerable attention in clinical applications because it decreases radiation risks. However, a lower dose generates noise in low-dose computed tomography (LDCT) images. Previous deep learning (DL)-based works have investigated ways to improve diagnostic performance to address this ill-posed problem. However, most of them disregard the anatomical differences among different human body sites in constructing the mapping function between LDCT images and their high-resolution normal-dose CT (NDCT) counterparts. In this article, we propose a novel deep convolutional neural network (CNN) denoising approach by introducing information of the anatomical prior. Instead of designing multiple networks for each independent human body anatomical site, a unified network framework is employed to process anatomical information. The anatomical prior is represented as a pattern of weights of the features extracted from the corresponding LDCT image in an anatomical prior fusion module. To promote diversity in the contextual information, a spatial attention fusion mechanism is introduced to capture many local regions of interest in the attention fusion module. Although many network parameters are saved, the experimental results demonstrate that our method, which incorporates anatomical prior information, is effective in denoising LDCT images. Furthermore, the anatomical prior fusion module could be conveniently integrated into other DL-based methods and avails the performance improvement on multiple anatomical data.