Biometric recognition plays an increasingly pivotal role in cybersecurity, where the CIA triad, Confidentiality, Integrity, and Availability, forms the cornerstone of information security, with authentication as a critical yet challenging component. This paper presents the Biometric Multi-modal Authentication System using Geometric Programming (BMMA-GPT), tailored for deployment in Fast IDentity Online (FIDO/FIDO2)-enabled environments and Zero Trust Architectures (ZTA). The system employs a dual-threshold mechanism integrated with Defense-in-Depth (DiD) strategies to simultaneously enhance accuracy, efficiency, and security. The underlying optimization problem is formulated as a mathematical programming task and reformulated into a Geometric Programming (GP) model to efficiently compute optimal biometric permutations and verification thresholds under constrained estimation errors. BMMA-GPT enables the flexible integration of multiple biometric modalities, allowing dynamic adjustments to meet both individual user profiles and organizational security requirements. It achieves a high Area Under Curve (AUC) of approximately 0.99 while maintaining authentication latency under 1.5 seconds. This design supports Chief Information Security Officers (CISOs) in configuring tailored authentication processes with minimal computational cost, enhancing resilience against spoofing attacks and ensuring seamless user experience. By aligning biometric verification with DiD principles and GP-based optimization, the proposed framework offers a scalable and robust solution for identity authentication in complex digital ecosystems.

Hepatocellular carcinoma (HCC), the most common type of liver cancer, poses significant challenges in detection and diagnosis. Medical imaging, especially computed tomography (CT), is pivotal in non-invasively identifying this disease, requiring substantial expertise for interpretation. This research introduces an innovative strategy that integrates two-dimensional (2D) and three-dimensional (3D) deep learning models within a federated learning (FL) framework for precise segmentation of liver and tumor regions in medical images. The study utilized 131 CT scans from the Liver Tumor Segmentation (LiTS) challenge and demonstrated the superior efficiency and accuracy of the proposed Hybrid-ResUNet model with a Dice score of 0.9433 and an AUC of 0.9965 compared to ResNet and EfficientNet models. This FL approach is beneficial for conducting large-scale clinical trials while safeguarding patient privacy across healthcare settings. It facilitates active engagement in problem-solving, data collection, model development, and refinement. The study also addresses data imbalances in the FL context, showing resilience and highlighting local models' robust performance. Future research will concentrate on refining federated learning algorithms and their incorporation into the continuous implementation and deployment (CI/CD) processes in AI system operations, emphasizing the dynamic involvement of clients. We recommend a collaborative human-AI endeavor to enhance feature extraction and knowledge transfer. These improvements are intended to boost equitable and efficient data collaboration across various sectors in practical scenarios, offering a crucial guide for forthcoming research in medical AI.