The organic Rankine cycle (ORC) is an effective application for converting low-grade heat sources into power and is crucial for environmentally friendly production and energy recovery. However, the inherent complexity of the mechanism, its strong and unidentified nonlinearity, and the presence of control constraints severely impair the design of its optimal controller. To solve these issues, this study provides a novel event-triggered (ET) constrained optimal control approach for the ORC systems based on a safe reinforcement learning technique to find the optimal control law. Instead of employing the usual non-quadratic integral form to solve the control-limited optimal control problems, a constraint handling strategy based on a relaxed weighted barrier function (BF) technique is proposed. By adding the BF terms to the original value function, a modified value iteration algorithm is developed to make the control input solutions that tend to violate the constraints be pushed back and maintained in their safe sets. In addition, the ET mechanism proposed in this article is critically required for the ORC systems, and it can significantly reduce the computational load. The combination of these two techniques allows the ORC systems to achieve set-point tracking control and satisfy the control restrictions. The proposed approach is conducted based on a heuristic dynamic programming framework with three neural networks (NNs) involved. The safety and convergence of the proposed approach and the stability of the closed-loop system are analyzed. Simulation results and comparisons are presented to demonstrate its effectiveness.