Mammogram image is important for breast cancer screening, and typically obtained in a dual-view form, i.e., cranio-caudal (CC) and mediolateral oblique (MLO), to provide complementary information for clinical decisions. However, previous methods mostly learn features from the two views independently, which violates the clinical knowledge and ignores the importance of dual-view correlation in the feature learning. In this paper, we propose a dual-view correlation hybrid attention network (DCHA-Net) for robust holistic mammogram classification. Specifically, DCHA-Net is carefully designed to extract and reinvent deep feature maps for the two views, and meanwhile to maximize the underlying correlations between them. A hybrid attention module, consisting of local relation and non-local attention blocks, is proposed to alleviate the spatial misalignment of the paired views in the correlation maximization. A dual-view correlation loss is introduced to maximize the feature similarity between corresponding strip-like regions with equal distance to the chest wall, motivated by the fact that their features represent the same breast tissues, and thus should be highly-correlated with each other. Experimental results on the two public datasets, i.e., INbreast and CBIS-DDSM, demonstrate that the DCHA-Net can well preserve and maximize feature correlations across views, and thus outperforms previous state-of-the-art methods for classifying a whole mammogram as malignant or not.

Deep convolutional neural networks (CNNs) have achieved impressive performance in medical image segmentation; however, their performance could degrade significantly when being deployed to unseen data with heterogeneous characteristics. Unsupervised domain adaptation (UDA) is a promising solution to tackle this problem. In this work, we present a novel UDA method, named dual adaptation-guiding network (DAG-Net), which incorporates two highly effective and complementary structural-oriented guidance in training to collaboratively adapt a segmentation model from a labelled source domain to an unlabeled target domain. Specifically, our DAG-Net consists of two core modules: 1) Fourier-based contrastive style augmentation (FCSA) which implicitly guides the segmentation network to focus on learning modality-insensitive and structural-relevant features, and 2) residual space alignment (RSA) which provides explicit guidance to enhance the geometric continuity of the prediction in the target modality based on a 3D prior of inter-slice correlation. We have extensively evaluated our method with cardiac substructure and abdominal multi-organ segmentation for bidirectional cross-modality adaptation between MRI and CT images. Experimental results on two different tasks demonstrate that our DAG-Net greatly outperforms the state-of-the-art UDA approaches for 3D medical image segmentation on unlabeled target images.