This article proposes a two-fold triple system (TFTS)-based obfuscation scheme as a structured physical-layer transmission technique for multiple-input multiple-output (MIMO) systems. TFTS is a class of combinatorial block designs that enables index-based spatial signaling without cryptographic keys or additional computational overhead. The proposed scheme constructs a space-modulation matrix derived from a TFTS of orderv, where each row corresponds to a unique antenna activation pattern transmitting unmodulated carriers. The TFTS combinatorial space is generated by merging two non-isomorphic Steiner triple systems, yielding a mapping space that grows super-exponentially withv. This growth becomes extreme even for moderate dimensions; for example, atv= 40, the number of valid TFTS realizations exceeds 1010258, rendering exhaustive reconstruction computationally infeasible. The TFTS constellation matrix is assumed to be pre-shared and securely stored at the legitimate transceivers, while an eavesdropper is modeled as a fully informed and computationally unbounded adversary that lacks the correct TFTS mapping and therefore operates under mismatched decoding. Under this adversary model, Eve’s demodulation decisions degrade to random guesses, resulting in an average bit error rate (ABER) approaching 0.5 and negligible exploitable information. Accordingly, the proposed framework is explicitly positioned as a physical-layer obfuscation mechanism rather than a secrecy-capacity or cryptographic security scheme. The obfuscation strength of the system is evaluated through information-leakage analysis, quantifying the mutual information between transmitted indices and Eve’s observations, as well as detectability analysis based on hypothesis testing. Simulation results demonstrate that the proposed TFTS-obfuscation scheme preserves strong performance for the intended receiver in terms of ABER, mutual information, and achievable rate, while maintaining minimal information leakage and low detectability at the eavesdropper.