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Thomas Minotto

dblp:307/3367 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2025
—ORCID · unresolved

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 4 heaviest of 4, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › comparative genomics › orthology analysis
ortholog identification
0.912025
Exploring homology detection via k-means clustering of proteins embedded with a large language model · Bioinform. 2025
Bioinformatics and computational biology › protein sequence analysis
protein homology detection
0.912025
Exploring homology detection via k-means clustering of proteins embedded with a large language model · Bioinform. 2025
Bioinformatics and computational biology › protein analysis › protein bioinformatics › protein representation learning
protein language model embedding
0.912025
Exploring homology detection via k-means clustering of proteins embedded with a large language model · Bioinform. 2025
Bioinformatics and computational biology › protein analysis › protein bioinformatics
protein representation learning
0.912025
Exploring homology detection via k-means clustering of proteins embedded with a large language model · Bioinform. 2025

Methods — techniques the papers use, named apart from their topics

large language model · 0.9k-means clustering · 0.9
YearPublicationVenuePosition
2025 Exploring homology detection via k-means clustering of proteins embedded with a large language model
abstract
MOTIVATION: Inferring protein homology from sequence information is essential for understanding species evolution and enabling functional annotation transfer. Besides similarity-based methods, several machine learning approaches have been developed using various ways of representing protein data. RESULTS: Here, we represent proteins with a biologically oriented large language model and apply k-means clustering to the embedded data to extract homology relationships. Although our approach lacks the sensitivity of other tools, we obtain better precision for the detection of n:m orthologs. Furthermore, we successfully reconstruct full orthologous groups from scratch, highlighting the growing potential of using large language models in combination with clustering algorithms for the analysis of protein data. AVAILABILITY AND IMPLEMENTATION: Datasets are available on OrthoMCL-DB as indicated in the Methods. Source code is available on GitHub at https://github.com/ThomasGTHB/OrthoLM and Zenodo at https://doi.org/10.5281/zenodo.16640170.
Thomas Minotto, Antoine Claessens, Thomas D. Otto
Bioinform.1