Abstract Clustering ensembles can obtain more superior final results by combining multiple different clustering results. The qualities of the points, clusters, and partitions play crucial roles in the consistency of the clustering process. However, existing methods mostly focus on one or two aspects of them, without a comprehensive consideration of the three aspects. This paper proposes a three-level weighted clustering ensemble algorithm namely unified point-cluser-partition algorithm (PCPA). The first step of the PCPA is to generate the adjacency matrix by base clusterings. Then, the central step is to obtain the weighted adjacency matrix by successively weighting three layers, i.e., points, clusters, and partitions. Finally, the consensus clustering is obtained by the average link method. Three performance indexes, namely F, NMI, and ARI, are used to evaluate the accuracy of the proposed method. The experimental results show that: Firstly, as expected, the proposed three-layer weighted clustering ensemble can improve the accuracy of each evaluation index by an average value of 22.07% compared with the direct clustering ensemble without weighting; Secondly, compared with seven other methods, PCPA can achieve better clustering results and the proportion that PCPA ranks first is 28/33.

Composed query image retrieval task aims to retrieve the target image in the database by a query that composes two different modalities: a reference image and a sentence declaring that some details of the reference image need to be modified and replaced by new elements. Tackling this task needs to learn a multimodal embedding space, which can make semantically similar targets and queries close but dissimilar targets and queries as far away as possible. Most of the existing methods start from the perspective of model structure and design some clever interactive modules to promote the better fusion and embedding of different modalities. However, their learning objectives use conventional query-level examples as negatives while neglecting the composed query's multimodal characteristics, leading to the inadequate utilization of the training data and suboptimal construction of metric space. To this end, in this paper, we propose to improve the learning objective by constructing and mining hard negative examples from the perspective of multimodal fusion. Specifically, we compose the reference image and its logically unpaired sentences rather than paired ones to create component-level negative examples to better use data and enhance the optimization of metric space. In addition, we further propose a new sentence augmentation method to generate more indistinguishable multimodal negative examples from the element level and help the model learn a better metric space. Massive comparison experiments on four real-world datasets confirm the effectiveness of the proposed method.

Genetic predisposition for complex traits often acts through multiple tissues at different time points during development. As a simple example, the genetic predisposition for obesity could be manifested either through inherited variants that control metabolism through regulation of genes expressed in the brain, or that control fat storage through dysregulation of genes expressed in adipose tissue, or both. Here we describe a statistical approach that leverages tissue-specific expression quantitative trait loci (eQTLs) corresponding to tissue-specific genes to prioritize a relevant tissue underlying the genetic predisposition of a given individual for a complex trait. Unlike existing approaches that prioritize relevant tissues for the trait in the population, our approach probabilistically quantifies the tissue-wise genetic contribution to the trait for a given individual. We hypothesize that for a subgroup of individuals the genetic contribution to the trait can be mediated primarily through a specific tissue. Through simulations using the UK Biobank, we show that our approach can predict the relevant tissue accurately and can cluster individuals according to their tissue-specific genetic architecture. We analyze body mass index (BMI) and waist to hip ratio adjusted for BMI (WHRadjBMI) in the UK Biobank to identify subgroups of individuals whose genetic predisposition act primarily through brain versus adipose tissue, and adipose versus muscle tissue, respectively. Notably, we find that these individuals have specific phenotypic features beyond BMI and WHRadjBMI that distinguish them from random individuals in the data, suggesting biological effects of tissue-specific genetic contribution for these traits.