Finding a particular object in a display is important for viewers in many visualizations, for example, when reacting to brushing or to a highlighted object. This can be enabled by making the target object different in one of the visual variables that determine the object's appearance; for example, by changing its color or size. Certain interpretations of the visual search literature have promoted the view that using visual variables such as hue-often labeled as preattentive-would make the target object automatically "popout," implying that an object can be located almost instantly, regardless of the number of objects in the display. In this paper we present a study that serves as a bridge between the extensive visual search literature and visualization, establishing empirical base measurements for the localization task. By testing displays with up to hundreds of objects, we are able to show that none of the common visual variables is immune to the increase in the number of objects. We also provide the first empirically informed comparisons between visual variables for this task in the context of visualization, and show how different visual variables have varying robustness with respect to two additional dimensions: the location of the target and the overall visual arrangement (layout). A free copy of this paper and all supplemental materials are available on our online repository: https://osf.io/z68ak/overview.

BACKGROUND: Dealing with the high dimension of both neuroimaging data and genetic data is a difficult problem in the association of genetic data to neuroimaging. In this article, we tackle the latter problem with an eye toward developing solutions that are relevant for disease prediction. Supported by a vast literature on the predictive power of neural networks, our proposed solution uses neural networks to extract from neuroimaging data features that are relevant for predicting Alzheimer's Disease (AD) for subsequent relation to genetics. The neuroimaging-genetic pipeline we propose is comprised of image processing, neuroimaging feature extraction and genetic association steps. We present a neural network classifier for extracting neuroimaging features that are related with the disease. The proposed method is data-driven and requires no expert advice or a priori selection of regions of interest. We further propose a multivariate regression with priors specified in the Bayesian framework that allows for group sparsity at multiple levels including SNPs and genes. RESULTS: We find the features extracted with our proposed method are better predictors of AD than features used previously in the literature suggesting that single nucleotide polymorphisms (SNPs) related to the features extracted by our proposed method are also more relevant for AD. Our neuroimaging-genetic pipeline lead to the identification of some overlapping and more importantly some different SNPs when compared to those identified with previously used features. CONCLUSIONS: The pipeline we propose combines machine learning and statistical methods to benefit from the strong predictive performance of blackbox models to extract relevant features while preserving the interpretation provided by Bayesian models for genetic association. Finally, we argue in favour of using automatic feature extraction, such as the method we propose, in addition to ROI or voxelwise analysis to find potentially novel disease-relevant SNPs that may not be detected when using ROIs or voxels alone.