Drug-target interaction (DTI) prediction plays a pivotal role in accelerating drug discovery. Nevertheless, existing AI-driven approaches face three critical limitations: existing attention-based methods lack dynamic bidirectional interaction channels, limiting their ability to model asymmetric drug-target communication patterns; conventional architectures struggle to integrate both local binding patterns and global biological contexts; and rigid prediction heads discarding spatial interaction patterns. These issues hamper the accuracy and comprehensiveness of DTI prediction. To address these, we propose CAMA-DTI, an end-to-end framework integrating three innovations. First, a cross-domain bidirectional attention module establishes dual-perspective interaction channels that enable co-evolutionary feature refinement through mutual pharmacological feedback. Second, the Mamba-driven fusion block incorporates state-space modeling to dynamically integrate local binding patterns with global biological contexts across extended sequences. Third, we replace conventional classifiers with Kolmogorov-Arnold Networks (KANs) employing adaptive spline transformations that preserve multi-scale interaction signatures while maintaining parametric efficiency. Extensive experimental results demonstrate that CAMA-DTI achieves robust and accurate predictions across diverse datasets, outperforming state-of-the-art methods in both established and novel drug target scenarios. Notably, the framework maintains consistent performance across datasets of varying scales, and case studies validate its practical utility in real-world drug development pipelines.

Enzyme catalytic efficiency (kcat/Km) is a key parameter for identifying high-activity enzymes. Recently, deep learning techniques have demonstrated the potential for fast and accurate kcat/Km prediction. However, three challenges remain: (i) the limited size of the available kcat/Km dataset hinders the development of deep learning models; (ii) the model predictions lack reliable confidence estimates; and (iii) models lack interpretable insights into enzyme-catalyzed reactions. To address these challenges, we proposed IECata, a kcat/Km prediction model that provides uncertainty estimation and interpretability. IECata collected a dataset of 11 815 kcat/Km entries from the BRENDA and SABIO-RK databases, along with an out-of-domain test dataset of 806 entries from the literature. By introducing evidential deep learning, IECata provides uncertainty estimates for kcat/Km predictions. Moreover, it uses a bilinear attention mechanism to focus on learning crucial local interactions to interpret the key residues and substrate atoms in enzyme-catalyzed reactions. Testing results indicate that the prediction performance of IECata exceeds that of state-of-the-art benchmark models. More importantly, it provides a reliable confidence assessment for these predictions. Case studies further highlight that the incorporation of uncertainty in screening for highly active enzymes can effectively increase the hit ratio, thereby improving the efficiency of experimental validation and accelerating directed enzyme evolution. To facilitate researchers' use of IECata, we have developed an online prediction platform: http://mathtc.nscc-tj.cn/cataai/.

As edge-based deep learning applications become more complex, optimizing performance on heterogeneous System-on-Chips (SoCs) presents unique challenges. Traditional pipelining techniques distributing the computation across different on-chip processing units, while effective for throughput, do not address the latency demands posed by modern neural networks with complex interdependencies and extensive operator parallelism. There is a potential in leveraging operator parallelism to enable concurrent execution across multiple processing units, thereby reducing inference latency. However, prioritizing pipelining or parallel execution often necessitates a compromise, where optimizing one performance metric adversely impacts the other. This paper introduces Para-Pipe, a hierarchical mapping framework that integrates intra-and inter-stage operator parallelism within a pipelined architecture. Para-Pipe navigates the trade-off between throughput and latency by selectively fine-tuning parallelism levels within and across pipeline stages. This strategy can significantly reduce inter-processor communication overhead, significantly improving energy efficiency. Our evaluation demonstrates that Para-Pipe generates multiple Pareto-optimal configurations, achieving a balance between throughput and latency on an Amlogic SoC equipped with ARM big.LITTLE CPUs and GPU, as well as the Black Sesame Technology SoC featuring a deep learning accelerator and two DSPs. More importantly, throughput-optimized configurations under Para-Pipe on Amlogic SoC show an average energy efficiency improvement of 11.0% over purely pipelined strategies and 23.3% relative to non-pipelined parallel execution.

Beamforming is a common technique used to improve speech intelligibility and listening comfort of hearing aids users in a noisy environment. Traditional hearing aids beamforming algorithms require the a priori knowledge of the auditory of the listener, which may not be available in real applications. Recent advances in electroencephalography (EEG) offer a potential non-invasive solution to this problem. The listener's auditory is derived from the EEG signals through auditory decoding algorithms and can be used as an input to the beamforming algorithms. In [1], a joint auditory decoding and adaptive beamforming algorithm framework by correlating the envelope of beamforming output and the EEG signal was proposed to improve the beamformer's robustness against decoding error. Consistent performance improvement was demonstrated on an EEG database recorded on listeners with fixed . In this study, we present the evaluation results of this joint formulation on a new EEG dataset collected on subjects with dynamic switch. We demonstrate not only the joint framework's performance improvement against decoding errors, but also its ability to capture listener's dynamic switch.