Motor imagery (MI) engages a broad network of brain regions to imagine a specific action. Investigating the mechanism of brain network reorganization during MI after spinal cord injury (SCI) is crucial because it reflects overall brain activity. Using electroencephalogram (EEG) data from SCI patients, we conducted EEG-based coherence analysis to examine different brain network reorganizations across different frequency bands, from resting to MI. Furthermore, we introduced a consistency calculation-based residual graph convolution (C-ResGCN) classification algorithm. The results show that the [Formula: see text]- and [Formula: see text]-band connectivity weakens, and brain activity decreases during the MI task compared to the resting state. In contrast, the [Formula: see text]-band connectivity increases in motor regions while the default mode network activity declines during MI. Our C-ResGCN algorithm showed excellent performance, achieving a maximum classification accuracy of 96.25%, highlighting its reliability and stability. These findings suggest that brain reorganization in SCI patients reallocates relevant brain resources from the resting state to MI, and effective network reorganization correlates with improved MI performance. This study offers new insights into the mechanisms of MI and potential biomarkers for evaluating rehabilitation outcomes in patients with SCI.

Stroke, an abrupt cerebrovascular ailment resulting in brain tissue damage, has prompted the adoption of motor imagery (MI)-based brain–computer interface (BCI) systems in stroke rehabilitation. However, analyzing electroencephalogram (EEG) signals from stroke patients poses challenges. To address the issues of low accuracy and efficiency in EEG classification, particularly involving MI, the study proposes a residual graph convolutional network (M-ResGCN) framework based on the modified S-transform (MST), and introduces the self-attention mechanism into residual graph convolutional network (ResGCN). This study uses MST to extract EEG time-frequency domain features, derives spatial EEG features by calculating the absolute Pearson correlation coefficient (aPcc) between channels, and devises a method to construct the adjacency matrix of the brain network using aPcc to measure the strength of the connection between channels. Experimental results involving 16 stroke patients and 16 healthy subjects demonstrate significant improvements in classification quality and robustness across tests and subjects. The highest classification accuracy reached 94.91% and a Kappa coefficient of 0.8918. The average accuracy and F1 scores from 10 times 10-fold cross-validation are 94.38% and 94.36%, respectively. By validating the feasibility and applicability of brain networks constructed using the aPcc in EEG signal analysis and feature encoding, it was established that the aPcc effectively reflects overall brain activity. The proposed method presents a novel approach to exploring channel relationships in MI-EEG and improving classification performance. It holds promise for real-time applications in MI-based BCI systems.

In software development, the raw requirements proposed by users are frequently incomplete, which impedes the complete implementation of software functionalities. With the emergence of large language models, the exploration of generating software through user requirements has attracted attention. Recent methods with the top-down waterfall model employ a questioning approach for requirement completion, attempting to explore further user requirements. However, users, constrained by their domain knowledge, result in a lack of effective acceptance criteria during the requirement completion, failing to fully capture the implicit needs of the user. Moreover, the cumulative errors of the waterfall model can lead to discrepancies between the generated code and user requirements. The Agile methodologies reduce cumulative errors of the waterfall model through lightweight iteration and collaboration with users, but the challenge lies in ensuring semantic consistency between user requirements and the code generated by the agent. To address these challenges, we propose AgileGen, an agile-based generative software development through human-AI teamwork. Unlike existing questioning agents, AgileGen adopts a novel collaborative approach that breaks free from the constraints of domain knowledge by initiating the end-user perspective to complete the acceptance criteria. By introducing the Gherkin language, AgileGen attempts for the first time to use testable requirement descriptions as a bridge for semantic consistency between requirements and code, aiming to ensure that software products meet actual user requirements by defining user scenarios that include acceptance criteria. Additionally, we innovate in the human-AI teamwork model, allowing users to participate in decision-making processes they do well and significantly enhancing the completeness of software functionality. To ensure semantic consistency between requirements and generated code, we derive consistency factors from Gherkin to drive the subsequent software code generation. Finally, to improve the reliability of user scenarios, we also introduce a memory pool mechanism, collecting user decision-making scenarios and recommending them to new users with similar requirements. AgileGen, as a user-friendly interactive system, significantly outperformed existing best methods by 16.4% and garnered higher user satisfaction.

Pain is an experience of unpleasant sensations and emotions associated with actual or potential tissue damage. In the global context, billions of people are affected by pain disorders. There are particular challenges in the measurement and assessment of pain, and the commonly used pain measuring tools include traditional subjective scoring methods and biomarker-based measures. The main tools for biomarker-based analysis are electroencephalography (EEG), electrocardiography and functional magnetic resonance. The EEG-based quantitative pain measurements are of immense value in clinical pain management and can provide objective assessments of pain intensity. The assessment of pain is now primarily limited to the identification of the presence or absence of pain, with less research on multilevel pain. High power laser stimulation pain experimental paradigm and five pain level classification methods based on EEG data augmentation are presented. First, the EEG features are extracted using modified S-transform, and the time-frequency information of the features is retained. Based on the pain recognition effect, the 20-40[Formula: see text]Hz frequency band features are optimized. Afterwards the Wasserstein generative adversarial network with gradient penalty is used for feature data augmentation. It can be inferred from the good classification performance of features in the parietal region of the brain that the sensory function of the parietal lobe region is effectively activated during the occurrence of pain. By comparing the latest data augmentation methods and classification algorithms, the proposed method has significant advantages for the five-level pain dataset. This research provides new ways of thinking and research methods related to pain recognition, which is essential for the study of neural mechanisms and regulatory mechanisms of pain.

Neonatal epilepsy is a common emergency phenomenon in neonatal intensive care units (NICUs), which requires timely attention, early identification, and treatment. Traditional detection methods mostly use supervised learning with enormous labeled data. Hence, this study offers a semi-supervised hybrid architecture for detecting seizures, which combines the extracted electroencephalogram (EEG) feature dataset and convolutional autoencoder, called Fd-CAE. First, various features in the time domain and entropy domain are extracted to characterize the EEG signal, which helps distinguish epileptic seizures subsequently. Then, the unlabeled EEG features are fed into the convolutional autoencoder (CAE) for training, which effectively represents EEG features by optimizing the loss between the input and output features. This unsupervised feature learning process can better combine and optimize EEG features from unlabeled data. After that, the pre-trained encoder part of the model is used for further feature learning of labeled data to obtain its low-dimensional feature representation and achieve classification. This model is performed on the neonatal EEG dataset collected at the University of Helsinki Hospital, which has a high discriminative ability to detect seizures, with an accuracy of 92.34%, precision of 93.61%, recall rate of 98.74%, and F1-score of 95.77%, respectively. The results show that unsupervised learning by CAE is beneficial to the characterization of EEG signals, and the proposed Fd-CAE method significantly improves classification performance.

Stroke, a sudden cerebrovascular ailment resulting from brain tissue damage, has prompted the use of motor imagery (MI)-based Brain-Computer Interface (BCI) systems in stroke rehabilitation. However, analyzing EEG signals from stroke patients is challenging because of their low signal-to-noise ratio and high variability. Therefore, we propose a novel approach that combines the modified S-transform (MST) and a dense graph convolutional network (DenseGCN) algorithm to enhance the MI-BCI performance across time, frequency, and space domains. MST is a time-frequency analysis method that efficiently concentrates energy in EEG signals, while DenseGCN is a deep learning model that uses EEG feature maps from each layer as inputs for subsequent layers, facilitating feature reuse and hyper-parameters optimization. Our approach outperforms conventional networks, achieving a peak classification accuracy of 90.22% and an average information transfer rate (ITR) of 68.52 bits per minute. Moreover, we conduct an in-depth analysis of the event-related desynchronization/event-related synchronization (ERD/ERS) phenomenon in the deep-level EEG features of stroke patients. Our experimental results confirm the feasibility and efficacy of the proposed approach for MI-BCI rehabilitation systems.

Deep learning-based epileptic seizure recognition via electroencephalogram signals has shown considerable potential for clinical practice. Although deep learning algorithms can enhance epilepsy identification accuracy compared with classical machine learning techniques, classifying epileptic activities based on the association between multichannel signals in electroencephalogram recordings is still challenging in automated seizure classification from electroencephalogram signals. Furthermore, the performance of generalization is hardly maintained by the fact that existing deep learning models were constructed using just one architecture. This study focuses on addressing this challenge using a hybrid framework. Alternatively put, a hybrid deep learning model, which is based on the ground-breaking graph neural network and transformer architectures, was proposed. The proposed deep architecture consists of a graph model to discover the inner relationship between multichannel signals and a transformer to reveal the heterogeneous associations between the channels. To evaluate the performance of the proposed approach, the comparison experiments were conducted on a publicly available dataset between the state-of-the-art algorithms and ours. Experimental results demonstrate that the proposed method is a potentially valuable instrument for epoch-based epileptic EEG classification.

Central neuropathic pain (CNP) after spinal cord injury (SCI) is related to the plasticity of cerebral cortex. The plasticity of cortex recorded by electroencephalogram (EEG) signal can be used as a biomarker of CNP. To analyze changes in the brain network mechanism under the combined effect of injury and pain or under the effect of pain, this paper mainly studies the changes of brain network functional connectivity in patients with neuropathic pain and without neuropathic pain after SCI. This paper has recorded the EEG with the CNP group after SCI, without the CNP group after SCI, and a healthy control group. Phase-locking value has been used to construct brain network topological connectivity maps. By comparing the brain networks of the two groups of SCI with the healthy group, it has been found that in the [Formula: see text] and [Formula: see text] frequency bands, the injury increases the functional connectivity between the frontal lobe and occipital lobes, temporal, and parietal of the patients. Furthermore, the comparison of brain networks between the group with CNP and the group without CNP after SCI has found that pain has a greater effect on the increased connectivity within the patients' frontal lobes. Motor imagery (MI) data of CNP patients have been used to extract one-dimensional local binary pattern (1D-LBP) and common spatial pattern (CSP) features, the left and right hand movements of the patients' MI have been classified. The proposed LBP-CSP feature method has achieved the highest accuracy of 98.6% and the average accuracy of 91.5%. The results of this study have great clinical significance for the neural rehabilitation and brain-computer interface of CNP patients.

Stroke patients are prone to fatigue during the EEG acquisition procedure, and experiments have high requirements on cognition and physical limitations of subjects. Therefore, how to learn effective feature representation is very important. Deep learning networks have been widely used in motor imagery (MI) based brain-computer interface (BCI). This paper proposes a contrast predictive coding (CPC) framework based on the modified s-transform (MST) to generate MST-CPC feature representations. MST is used to acquire the temporal-frequency feature to improve the decoding performance for MI task recognition. EEG2Image is used to convert multi-channel one-dimensional EEG into two-dimensional EEG topography. High-level feature representations are generated by CPC which consists of an encoder and autoregressive model. Finally, the effectiveness of generated features is verified by the k-means clustering algorithm. It can be found that our model generates features with high efficiency and a good clustering effect. After classification performance evaluation, the average classification accuracy of MI tasks is 89% based on 40 subjects. The proposed method can obtain effective feature representations and improve the performance of MI-BCI systems. By comparing several self-supervised methods on the public dataset, it can be concluded that the MST-CPC model has the highest average accuracy. This is a breakthrough in the combination of self-supervised learning and image processing of EEG signals. It is helpful to provide effective rehabilitation training for stroke patients to promote motor function recovery.

Automatic seizure detection from electroencephalography (EEG) based on deep learning has been significantly improved. However, existing works have not adequately excavate the spatial-temporal information between EEG channels. Besides, most works mainly focus on patient-specific scenarios while cross-patient seizure detection is more challenging and meaningful. Regarding the above problems, we propose a hybrid attention network (HAN) for automatic seizure detection. Specifically, the graph attention network (GAT) extracts spatial features at the front end, and Transformer gets time features as the back end. HAN leverages the attention mechanism and fully extracts the spatial-temporal correlation of EEG signals. The focal loss function is introduced to HAN to deal with the imbalance of the dataset accompanied by seizure detection based on EEG. Both patient-specific and patient-independent experiments are carried out on the public CHB-MIT database. Experimental results demonstrate the efficacy of HAN in both experimental settings.

Feature extraction is an essential procedure in the detection and recognition of epilepsy, especially for clinical applications. As a type of multichannel signal, the association between all of the channels in EEG samples can be further utilized. To implement the classification of epileptic seizures from the nonseizures in EEG samples, one graph convolutional neural network (GCNN)-based framework is proposed for capturing the spatial enhanced pattern of multichannel signals to characterize the behavior of EEG activity, which is capable of visualizing the salient regions in each sequence of EEG samples. Meanwhile, the presented GCNN could be exploited to discriminate normal, ictal and interictal EEGs as a novel classifier. To evaluate the proposed approach, comparison experiments were conducted between state-of-the-art techniques and ours. From the experimental results, we found that for ictal and interictal EEG signal discrimination, the presented approach can achieve a sensitivity of 98.33%, specificity of 99.19% and accuracy of 98.38%.

The motor imagery brain-computer interface (MI-BCI) system is currently one of the most advanced rehabilitation technologies, and it can be used to restore the motor function of stroke patients. The deep learning algorithms in the MI-BCI system require lots of training samples, but the electroencephalogram (EEG) data of stroke patients is quite scarce. Therefore, the expansion of EEG data has become an important part of stroke clinical rehabilitation research. In this paper, a deep convolution generative adversarial network (DCGAN) model is proposed to generate artificial EEG data and further expand the scale of the stroke dataset. First, multichannel one-dimensional EEG data is converted into a two-dimensional EEG spectrogram using EEG2Image based on the modified S-transform. Then, DCGAN is used to artificially generate EEG data based on MI. Finally, the validity of the generated artificial EEG data is proved. This paper preliminarily indicates that generating artificial stroke data is a promising strategy, which contributes to the further development of stroke clinical rehabilitation.

Epilepsy is a neurological disorder caused by brain dysfunction, which could cause uncontrolled behavior, loss of consciousness and other hazards. Electroencephalography (EEG) is an indispensable auxiliary tool for clinical diagnosis. Great progress has been made by current seizure identification methods. However, the performance of the methods on different patients varies a lot. In order to deal with this problem, we propose an automatic seizure identification method based on brain connectivity learning. The connectivity of different brain regions is modeled by a graph. Different from the manually defined graph structure, our method can extract the optimal graph structure and EEG features in an end-to-end manner. Combined with the popular graph attention neural network (GAT), this method achieves high performance and stability on different patients from the CHB-MIT dataset. The average values of accuracy, sensitivity, specificity, F1-score and AUC of the proposed model are 98.90%, 98.33%, 98.48%, 97.72% and 98.54%, respectively. The standard deviations of the above five indicators are 0.0049, 0.0125, 0.0116 and 0.0094, respectively. Compared with the existing seizure identification methods, the stability of the proposed model is improved by 78-95%.

To develop an efficient brain-computer interface (BCI) system, electroencephalography (EEG) measures neuronal activities in different brain regions through electrodes. Many EEG-based motor imagery (MI) studies do not make full use of brain network topology. In this paper, a deep learning framework based on a modified graph convolution neural network (M-GCN) is proposed, in which temporal-frequency processing is performed on the data through modified S-transform (MST) to improve the decoding performance of original EEG signals in different types of MI recognition. MST can be matched with the spatial position relationship of the electrodes. This method fusions multiple features in the temporal-frequency-spatial domain to further improve the recognition performance. By detecting the brain function characteristics of each specific rhythm, EEG generated by imaginary movement can be effectively analyzed to obtain the subjects' intention. Finally, the EEG signals of patients with spinal cord injury (SCI) are used to establish a correlation matrix containing EEG channel information, the M-GCN is employed to decode relation features. The proposed M-GCN framework has better performance than other existing methods. The accuracy of classifying and identifying MI tasks through the M-GCN method can reach 87.456%. After 10-fold cross-validation, the average accuracy rate is 87.442%, which verifies the reliability and stability of the proposed algorithm. Furthermore, the method provides effective rehabilitation training for patients with SCI to partially restore motor function.

Electroencephalogram (EEG) plays an important role in recording brain activity to diagnose epilepsy. However, it is not only laborious, but also not very cost effective for medical experts to manually identify the features on EEG. Therefore, automatic seizure detection in accordance with the EEG recordings is significant for the diagnosis and treatment of epilepsy. Here, a new method for detecting seizures using tensor distance (TD) is proposed. First, the time-frequency characteristics of EEG signals are obtained by wavelet transformation, and the tensor representation of EEG signals is then obtained. Tucker decomposition is used to obtain the principal components of the EEG tensor. After, the distances between different categories of EEG tensors are calculated as the EEG features. Finally, the TD features are classified through the Bayesian Linear Discriminant Analysis (Bayesian LDA) classifier. The performance of this method is measured by the sensitivity, specificity, and recognition accuracy. Results indicate 95.12% sensitivity, 97.60% specificity, 97.60% recognition accuracy, and a false detection rate of 0.76 per hour in the invasive EEG dataset, which included 566.57[Formula: see text]h of EEG recording data from 21 patients. Taken together, the results show that TD has a good detection effect for seizure classification and that this method has high computational speed and great potential for real-time diagnosis.

Automatic seizure detection from electroencephalogram (EEG) plays a vital role in accelerating epilepsy diagnosis. Previous researches on seizure detection mainly focused on extracting time-domain and frequency-domain features from single electrodes, while paying little attention to the positional correlations between different EEG channels of the same subject. Moreover, data imbalance is common in seizure detection scenarios where the duration of nonseizure periods is much longer than the duration of seizures. To cope with the two challenges, a novel seizure detection method based on graph attention network (GAT) is presented. The approach acts on graph-structured data and takes the raw EEG data as input. The positional relationship between different EEG signals is exploited by GAT. The loss function of the GAT model is redefined using the focal loss to tackle data imbalance problem. Experiments are conducted on the CHB-MIT dataset. The accuracy, sensitivity and specificity of the proposed method are 98.89[Formula: see text], 97.10[Formula: see text] and 99.63[Formula: see text], respectively.

Reliable epileptic seizure prediction is significantly important in improving the life of patients and enhancing the therapy effect. In this paper, a novel seizure prediction algorithm is proposed employing the tensor decomposition on long-term intracranial EEG recordings. The modified Stockwell transform (MST) is conducted on the segmented EEG signals to transform into two-dimensional instantaneous power spectra. Then, the third-order tensor representation of the multi-channel EEG signals are structured with the models of time, frequency and space. Tucker decomposition, one valid tensor decomposition method, is applied to obtain the principal components of the EEG tensors and the smaller core tensors after decomposition are extracted as features of interictal EEG and preictal EEG. After that, the classification of preictal and interictal data is achieved by feeding the features into Bayesian Linear Discriminant Analysis (BLDA) classifier. The evaluation of the proposed algorithm is carried out on the Freiburg EEG database and a sensitivity of 88.49% for the seizure occurrence period of 30 min, meanwhile, a sensitivity of 97.62% for the seizure occurrence period of 50 min are yielded with a false alarm rate of 0. 25/h. The results show that this algorithm based on tensor analysis has notable performance for seizure prediction.

We present BusTr, a machine-learned model for translating road traffic forecasts into predictions of bus delays, used by Google Maps to serve the majority of the world's public transit systems where no official real-time bus tracking is provided. We demonstrate that our neural sequence model improves over DeepTTE, the state-of-the-art baseline, both in performance (-30% MAPE) and training stability. We also demonstrate significant generalization gains over simpler models, evaluated on longitudinal data to cope with a constantly evolving world.

Various image pre‐processing tasks in optical coherence tomography (OCT) systems involve reversing degradation effects (e.g. deblurring). Current deblurring research mainly focuses on how to build suitable degradation models using deconvolution operators. However, model‐based solutions may not work well in many scenarios. To solve this problem, the authors propose a non‐model architecture, called a deep convolutional neural network, to address parameter‐free situations. The proposed solution employs a deep learning strategy to bridge the gap between traditional model‐based methods and neural network architectures. Experiments on retinal OCT images demonstrate that the proposed approach achieves superior performance compared with the state‐of‐the‐art model‐based OCT deblurring methods.

The automatic identification of epileptic electroencephalogram (EEG) signals can give assistance to doctors in diagnosis of epilepsy, and provide the higher security and quality of life for people with epilepsy. Feature extraction of EEG signals determines the performance of the whole recognition system. In this paper, a novel method using the local binary pattern (LBP) based on the wavelet transform (WT) is proposed to characterize the behavior of EEG activities. First, the WT is employed for time-frequency decomposition of EEG signals. After that, the "uniform" LBP operator is carried out on the wavelet-based time-frequency representation. And the generated histogram is regarded as EEG feature vector for the quantification of the textural information of its wavelet coefficients. The LBP features coupled with the support vector machine (SVM) classifier can yield the satisfactory recognition accuracies of 98.88% for interictal and ictal EEG classification and 98.92% for normal, interictal and ictal EEG classification on the publicly available EEG dataset. Moreover, the numerical results on another large size EEG dataset demonstrate that the proposed method can also effectively detect seizure events from multi-channel raw EEG data. Compared with the standard LBP, the "uniform" LBP can obtain the much shorter histogram which greatly reduces the computational burden of classification and enables it to detect ictal EEG signals in real time.

The feature extraction and classification of brain signal is very significant in brain-computer interface (BCI). In this study, we describe an algorithm for motor imagery (MI) classification of electrocorticogram (ECoG)-based BCI. The proposed approach employs multi-resolution fractal measures and local binary pattern (LBP) operators to form a combined feature for characterizing an ECoG epoch recording from the right hemisphere of the brain. A classifier is trained by using the gradient boosting in conjunction with ordinary least squares (OLS) method. The fractal intercept, lacunarity and LBP features are extracted to classify imagined movements of either the left small finger or the tongue. Experimental results on dataset I of BCI competition III demonstrate the superior performance of our method. The cross-validation accuracy and accuracy is 90.6% and 95%, respectively. Furthermore, the low computational burden of this method makes it a promising candidate for real-time BCI systems.