The brain can learn to solve a wide range of tasks with high temporal and energetic efficiency. However, most biological models are composed of simple single-compartment neurons and cannot achieve the state-of-the-art performances of artificial intelligence. We propose a multi-compartment model of pyramidal neuron, in which bursts and dendritic input segregation give the possibility to plausibly support a biological target-based learning. In target-based learning, the internal solution of a problem (a spatio-temporal pattern of bursts in our case) is suggested to the network, bypassing the problems of error backpropagation and credit assignment. Finally, we show that this neuronal architecture naturally supports the orchestration of “hierarchical imitation learning”, enabling the decomposition of challenging long-horizon decision-making tasks into simpler subtasks.

Visual object recognition has been extensively studied in both neuroscience and computer vision. Recently, the most popular class of artificial systems for this task, deep convolutional neural networks (CNNs), has been shown to provide excellent models for its functional analogue in the brain, the ventral stream in visual cortex. This has prompted questions on what, if any, are the common principles underlying the reformatting of visual information as it flows through a CNN or the ventral stream. Here we consider some prominent statistical patterns that are known to exist in the internal representations of either CNNs or the visual cortex and look for them in the other system. We show that intrinsic dimensionality (ID) of object representations along the rat homologue of the ventral stream presents two distinct expansion-contraction phases, as previously shown for CNNs. Conversely, in CNNs, we show that training results in both distillation and active pruning (mirroring the increase in ID) of low- to middle-level image information in single units, as representations gain the ability to support invariant discrimination, in agreement with previous observations in rat visual cortex. Taken together, our findings suggest that CNNs and visual cortex share a similarly tight relationship between dimensionality expansion/reduction of object representations and reformatting of image information.

The field of recurrent neural networks is over-populated by a variety of proposed learning rules and protocols. The scope of this work is to define a generalized framework, to move a step forward towards the unification of this fragmented scenario. In the field of supervised learning, two opposite approaches stand out, error-based and target-based. This duality gave rise to a scientific debate on which learning framework is the most likely to be implemented in biological networks of neurons. Moreover, the existence of spikes raises the question of whether the coding of information is rate-based or spike-based. To face these questions, we proposed a learning model with two main parameters, the rank of the feedback learning matrix [Formula: see text] and the tolerance to spike timing τ⋆. We demonstrate that a low (high) rank [Formula: see text] accounts for an error-based (target-based) learning rule, while high (low) tolerance to spike timing promotes rate-based (spike-based) coding. We show that in a store and recall task, high-ranks allow for lower MSE values, while low-ranks enable a faster convergence. Our framework naturally lends itself to Behavioral Cloning and allows for efficiently solving relevant closed-loop tasks, investigating what parameters [Formula: see text] are optimal to solve a specific task. We found that a high [Formula: see text] is essential for tasks that require retaining memory for a long time (Button and Food). On the other hand, this is not relevant for a motor task (the 2D Bipedal Walker). In this case, we find that precise spike-based coding enables optimal performances. Finally, we show that our theoretical formulation allows for defining protocols to estimate the rank of the feedback error in biological networks. We release a PyTorch implementation of our model supporting GPU parallelization.