MOTIVATION: Single-cell multi-omics data integration is essential for understanding cellular states and disease mechanisms, yet integrating heterogeneous data modalities remains a challenge. We present scMGCL, a graph contrastive learning framework for robust integration of single-cell ATAC-seq and RNA-seq data. Our approach leverages self-supervised learning on cell-cell similarity graphs, in which each modality's graph structure serves as an augmentation for the other. This cross-modality contrastive paradigm enables the learning of biologically meaningful, shared representations while preserving modality-specific features. RESULTS: Benchmarking against state-of-the-art methods demonstrates that scMGCL outperforms others in cell-type clustering, label transfer accuracy, and preservation of marker-gene correlations. Additionally, scMGCL significantly improves computational efficiency, reducing runtime and memory usage. The method's effectiveness is further validated through extensive analyses of cell-type similarity and functional consistency, providing a powerful tool for multi-omics data exploration. AVAILABILITY AND IMPLEMENTATION: Code and datasets are released at https://github.com/zlCreator/scMGCL.

Prior research suggests that affective states of self-regulated learning can be used to improve learners’ cognitive processes and their learning outcomes. However, little research explored the effect of using facial movements to detect learners’ affective states on self-regulated learning. In this work, we designed, implemented, and evaluated Mirror: a self-regulated learning tool that applies facial expression recognition to support learners’ reflections in video-based learning. We conducted two studies to identify user needs (with 12 participants) and to evaluate the tool (with 16 participants). The results show that, after watching a video, participants benefited from using Mirror through different reflection processes, e.g., gaining a deeper understanding of their learning experiences through self-observation and attributing causes for their learning affects through self-judgment. Meanwhile, we also identified several ethical concerns, e.g., users’ agency of handling the uncertainty of AI, reactivity towards outcome-based AI, over-reliance on “positive” AI results, and fairness of AI informed decision-making.