Given an acyclic digraph $G = (V,E)$ and a positive integer $k$, the problem of Maximum Coverage $k$-Antichains (resp. Chains) denoted as MA-$k$ (resp. MC-$k$) asks to find $k$ sets of pairwise unreachable vertices, known as antichains (resp. $k$ subsequences of paths, known as chains), maximizing the number $α_k$ (resp. $β_k$) of vertices covered by these antichains (resp. chains). While MC-$k$ was solved in almost optimal $|E|^{1+o(1)}$ time~[Kogan and Parter, ICALP'22], the fastest algorithms for MA-$k$ are a $(k|E|)^{1+o(1)}$-time solution and a $|E|^{1+o(1)}$-time $1/2$ approximation~[Kogan and Parter, ESA'24]. We obtain the following for MA-$k$: - An algorithm running in $|E|^{1+o(1)}$ time, and an algorithm running in parameterized near-linear $\tilde{O}(α_k |E|)$ time. Our algorithms are simple solutions exploiting a paths-based proof of the Greene-Kleitman theorems leveraged by the greedy algorithm for set cover as well as recent advances in fast algorithms for flows and shortest paths. - An approximation algorithm running in parameterized linear time $O(α_1^2|V| + (α_1+k)|E|)$ with approximation ratio of $(1-1/e) > 0.63 > 1/2$, beating the state-of-the-art $1/2$ approximation. Our solution uses greedy for antichains and a simple strategy to amortize the cost of computing consecutive maximum antichains. We complement these results with two examples (one for chains and one for antichains) showing that, for every $k \ge 2$, greedy misses the tight $1/e$ portion of the optimal coverage for chains, and a $1/4$ portion for antichains. We also show that greedy is a $Ω(\log{|V|})$ factor away from minimality when required to cover all vertices: previously unknown for sets of chains or antichains.

Quantified Boolean Formula (QBF) is a notoriously hard generalization of SAT, especially from the point of view of parameterized complexity, where the problem remains intractable for most standard parameters. A recent work by Eriksson et al. [IJCAI 24] addressed this by considering the case where the propositional part of the formula is in CNF and we parameterize by the number k of existentially quantified variables. One of their main results was that this natural (but so far overlooked) parameter does lead to fixed-parameter tractability, if we also bound the maximum arity d of the clauses of the given CNF. Unfortunately, their algorithm has a double-exponential dependence on k (2^{2^k}), even when d is an absolute constant. Since the work of Eriksson et al. only complemented this with a SETH-based lower bound implying that a 2^{O(k)} dependence is impossible, this left a large gap as an open question. Our main result in this paper is to close this gap by showing that the double-exponential dependence is optimal, assuming the ETH: even for CNFs of arity 4, QBF with k existential variables cannot be solved in time 2^{2^o(k)} |φ|^O(1). Complementing this, we also consider the further restricted case of QBF with only two quantifier blocks (∀∃-QBF). We show that in this case the situation improves dramatically: for each d ≥ 3 we show an algorithm with running time k^O_d(k^{d-1}) |φ|^O(1) (where the notation O_d hides factors depending on d) and a lower bound under the ETH showing our algorithm is almost optimal.

SUMMARY: Life over the past four billion years has been shaped by proteins and their capacity to assemble into three-dimensional conformations. Protein sequence alignments have been the enabling technology for exploring the evolution and functional adaptation of proteins across the tree of life. Recent advancements in scaling the prediction of three-dimensional protein structures from primary sequence alone, revealed that different modes of conservation and function operate on the sequence and structure level. This difference in protein conservation patterns and their underlying functional change that could emerge in suboptimal alignment configurations is often ignored in optimal protein alignment approaches. We introduce EMERALD-UI, an open-source interactive web application which is designed to reveal unexplored biology by visualising stable structural conformations or protein regions hidden in the alternative alignment space. AVAILABILITY: EMERALD-UI is available at https://algbio.github.io/emerald-ui/. The source code of the version described in this manuscript is available at https://github.com/algbio/emerald-ui and archived at Software Heritage: swh: 1: dir: 8b5a70160396d5e9a2e6d015c3b6f1426176d9a4.

Minimum flow decomposition (MFD) is the NP-hard problem of finding a smallest decomposition of a network flow/circulation X on a directed graph G into weighted source-to-sink paths whose weighted sum equals X . We show that, for acyclic graphs, considering the width of the graph (the minimum number of paths needed to cover all of its edges) yields advances in our understanding of its approximability. For the version of the problem that uses only non-negative weights, we identify and characterise a new class of width-stable graphs, for which a popular heuristic is a O (log Val ( X ))-approximation ( Val ( X ) being the total flow of X ), and strengthen its worst-case approximation ratio from \(\Omega (\sqrt {m})\) to Ω ( m /log m ) for sparse graphs, where m is the number of edges in the graph. We also study a new problem on graphs with cycles, Minimum Cost Circulation Decomposition (MCCD), and show that it generalises MFD through a simple reduction. For the version allowing also negative weights, we give a (⌈ log ‖ X ‖ ⌉ +1)-approximation (‖ X ‖ being the maximum absolute value of X on any edge) using a power-of-two approach, combined with parity fixing arguments and a decomposition of unitary circulations (‖ X ‖ ≤ 1), using a generalised notion of width for this problem. Finally, we disprove a conjecture about the linear independence of minimum (non-negative) flow decompositions posed by Kloster et al. [ 2018 ], but show that its useful implication (polynomial-time assignments of weights to a given set of paths to decompose a flow) holds for the negative version.

Minimum flow decomposition (MFD) is the NP-hard problem of finding a smallest decomposition of a network flow/circulation $X$ on a directed graph $G$ into weighted source-to-sink paths whose superposition equals $X$. We show that, for acyclic graphs, considering the \emph{width} of the graph (the minimum number of paths needed to cover all of its edges) yields advances in our understanding of its approximability. For the version of the problem that uses only non-negative weights, we identify and characterise a new class of \emph{width-stable} graphs, for which a popular heuristic is a \gwsimple-approximation ($|X|$ being the total flow of $X$), and strengthen its worst-case approximation ratio from $Ω(\sqrt{m})$ to $Ω(m / \log m)$ for sparse graphs, where $m$ is the number of edges in the graph. We also study a new problem on graphs with cycles, Minimum Cost Circulation Decomposition (MCCD), and show that it generalises MFD through a simple reduction. For the version allowing also negative weights, we give a $(\lceil \log \Vert X \Vert \rceil +1)$-approximation ($\Vert X \Vert$ being the maximum absolute value of $X$ on any edge) using a power-of-two approach, combined with parity fixing arguments and a decomposition of unitary circulations ($\Vert X \Vert \leq 1$), using a generalised notion of width for this problem. Finally, we disprove a conjecture about the linear independence of minimum (non-negative) flow decompositions posed by Kloster et al. [ALENEX 2018], but show that its useful implication (polynomial-time assignments of weights to a given set of paths to decompose a flow) holds for the negative version.