Accurate detection and prevalence estimation of behavioral health conditions, such as opioid use disorder (OUD), are crucial for identifying at-risk individuals, determining treatment needs, monitoring prevention and intervention efforts, and recruiting treatment-naive participants for clinical trials. The availability of extensive health data, combined with advancements in machine learning (ML) frameworks, has enabled researchers to employ various ML techniques to predict or identify OUD within patient health data. Ideally, we could directly estimate the prevalence, or the proportion of a population with a condition over time. However, underdiagnosis and undercoding of conditions in patient health records make it challenging to determine the true prevalence of these conditions and to identify at-risk patients with less severe conditions who are more likely to be missed. Consequently, patients without diagnoses may comprise positive and negative examples for a given condition. Treating all undiagnosed (uncoded) patients as negative when applying ML methods can introduce bias into models, affecting their predictive power. To address this issue, we employed Positive Unlabeled Learning Selected Not At Random (PULSNAR), a Positive and Unlabeled (PU) learning technique, to estimate the probability of a given patient having OUD during a time window and the overall population prevalence of OUD. In a sample of 3,342,044 commercially insured US patients with at least one opioid prescription filled, PULSNAR estimated that 5.08% of patients have a cumulative prevalence of OUD over a 2-5 a observation period, compared to the 1.35% with a recorded OUD diagnosis, with 73.5% of cases not diagnosed/coded. The prevalence estimates provided by PULSNAR are consistent with those reported in other studies.

Cyber vulnerabilities are security deficiencies in computer and network systems of organizations, which can be exploited by an adversary to cause significant damage. The technology and security personnel resources currently available in organizations to mitigate the vulnerabilities are highly inadequate. As a result, systems routinely remain unpatched, thus making them vulnerable to security breaches from the adversaries. The potential consequences of an exploited vulnerability depend upon the context as well as the severity of the vulnerability, which may differ among networks and organizations. Furthermore, security personnel tend to have varying levels of expertise and technical proficiencies associated with different computer and network devices. There exists a critical need to develop a resource-constrained approach for effectively identifying and mitigating important context-sensitive cyber vulnerabilities. In this article, we develop an advanced analytics and optimization framework to address this need and compare our approach with rule-based methods employed in real-world cybersecurity operations centers, as well as a vulnerability prioritization method from recent literature. First, we propose a machine learning-based vulnerability priority scoring system (VPSS) to calculate the priority scores for each of the vulnerabilities found in an organization’s network and quantify organizational context-based vulnerability exposure. Next, we propose a decision-support system, which consists of a two-step sequential optimization approach. The first model selects the high priority vulnerability instances from the dense report subject to resource constraints, and the second model then optimally allocates them to the security personnel with matching skill types for mitigation. Experiment results conducted using a real-world vulnerability data set show that our approach 1) outperforms both the rule-based methods and the vulnerability prioritization method from literature in prioritizing context-sensitive vulnerabilities, which are found across highly susceptible organizationally relevant host machines, and 2) maximizes the pairs of vulnerability instance type and the respective security analyst skill type for optimal mitigation.

DNA-stabilized silver nanoclusters (AgN-DNAs) are a class of nanomaterials comprised of 10-30 silver atoms held together by short synthetic DNA template strands. AgN-DNAs are promising biosensors and fluorophores due to their small sizes, natural compatibility with DNA, and bright fluorescence---the property of absorbing light and re-emitting light of a different color. The sequence of the DNA template acts as a "genome" for AgN-DNAs, tuning the size of the encapsulated silver nanocluster, and thus its fluorescence color. However, current understanding of the AgN-DNA genome is still limited. Only a minority of DNA sequences produce highly fluorescent AgN-DNAs, and the bulky DNA strands and complex DNA-silver interactions make it challenging to use first principles chemical calculations to understand and design AgN-DNAs. Thus, a major challenge for researchers studying these nanomaterials is to develop methods to employ observational data about studied AgN-DNAs to design new nanoclusters for targeted applications.