Accurate travel time estimation (TTE) plays a crucial role in intelligent transportation systems. However, it remains challenging due to heterogeneous data sources and complex traffic dynamics. Moreover, traditional approaches typically convert trajectory data into fixed-length representations. This overlooks the inherent variability of real-world motion patterns, often resulting in information loss and redundancy. To address these challenges, this paper introduces the Multimodal Dynamic Trajectory Integration (MDTI) framework--a novel multimodal trajectory representation learning approach that integrates GPS sequences, grid trajectories, and road network constraints to enhance the performance of TTE. MDTI employs modality-specific encoders and a multimodal fusion module to capture complementary spatial, temporal, and topological semantics, while a dynamic trajectory modeling mechanism adaptively regulates information density for trajectories of varying lengths. Two self-supervised pretraining objectives, named contrastive alignment and masked language modeling, further strengthen multimodal consistency and contextual understanding. Extensive experiments on three real-world datasets demonstrate that MDTI consistently outperforms state-of-the-art baselines, confirming its robustness and strong generalization abilities. The code is publicly available at: https://github.com/City-Computing/MDTI.

With the rapid development of pathology foundation models, there is a growing demand for efficient fine-tuning strategies tailored to downstream tasks. However, existing parameter-efficient fine-tuning approaches are largely task-agnostic and exhibit limited generalization to histopathological images, particularly for unseen cancers and stains, due to substantial stain variability and the complexity of tissue microenvironments. To address these challenges, we present Histopathology-induced Adapter (HiAdapter), which incorporates domain-specific insights into staining and imaging mechanisms of histopathology. HiAdapter reconstructs stain-invariant representations via a Stain-invariant Adapter (S-Adapter) and integrates morphological features through a Morphology-aware Adapter (M-Adapter), effectively bridging the gap between low-level optical properties and high-level tissue semantics. Additionally, we introduce a Pathology Prototypical Contrastive Loss (PPCLoss) to reduce inter-class similarity and mitigate intra-class heterogeneity, enhancing feature discriminability. Extensive experiments using three pathology foundation models (CTransPath, CONCH and UNI) across six benchmarks, including two public datasets, an osteosarcoma tissue classification dataset (56,178 patches) and a chondrosarcoma necrosis classification dataset (3,867 patches) for unseen cancers generalization, as well as an IHC-stained dataset (4,967 patches) and an HIF1A IHC-stained dataset (4,433 patches) for unseen stains generalization, demonstrate the effectiveness of HiAdapter in both efficiency and accuracy. HiAdapter achieves an average improvement of 2.15 in F1 and 1.55 in accuracy over the second-best performer, maintaining strong biological and diagnostic interpretability. External validation on an independent osteosarcoma dataset (9,535 patches) and WSI-level survival analysis (178 slides) further confirm the superior generalizability and underscore the potential for patient-level diagnosis and prognosis in clinical practice. Our code is available at https://github.com/idata-ora/HiAdapter.

Federated Graph Learning (FGL) has emerged as a key paradigm for distributed graph machine learning, enabling cross-domain graph collaborative modeling while preserving data privacy. However, existing methods face two major bottlenecks: the structural heterogeneity discrepancy of graph data among clients weakens the generalization ability of the global model; and model heterogeneity leads to inefficient knowledge sharing and complex global aggregation. To address these issues, we propose FedGVD, an efficient framework that constructs a global perspective through data condensation and server-side virtual node generation, which not only preserves the semantic equivalence of the original data but also avoids privacy leakage. Subsequently, by distributing low-dimensional generalizable knowledge for unidirectional distillation, FedGVD enables local models to absorb global knowledge without transmitting local parameters, thus breaking through the challenges of data and structural heterogeneity as well as model heterogeneity. This innovative approach ensures privacy-preserving and efficient federated graph collaboration. Experiments show that FedGVD maintains excellent performance in heterogeneous model scenarios while significantly improving communication efficiency, offering a new approach for privacy-preserving collaborative modeling in FGL. The code is available at https://github.com/Jasonxx4/FedGVD.

MOTIVATION: Heart failure (HF), a major cause of morbidity and mortality, necessitates precise diagnostic and prognostic methods. RESULTS: This study presents a novel deep learning approach, Transformer-based Analysis of Images of Tissue for Effective Remedy (TRAITER), for HF diagnosis and prognosis. Using image segmentation techniques and a Vision Transformer, TRAITER predicts HF likelihood from cardiac tissue cell nuclear morphology images and the potential for left ventricular reverse remodeling (LVRR) from dual-stained images with cell nuclei and DNA damage markers. In HF prediction using 31 158 images from 9 patients, TRAITER achieved 83.1% accuracy. For LVRR prediction with 231 840 images from 46 patients, TRAITER attained 84.2% accuracy for individual images and 92.9% for individual patients. TRAITER outperformed other neural network models in terms of receiver operating characteristics, and precision-recall curves. Our method promises to advance personalized HF medicine decision-making. AVAILABILITY AND IMPLEMENTATION: The source code and data are available at the following link: https://github.com/HamanoLaboratory/predict-of-HF-and-LVRR.

Unmanned aerial vehicle (UAV)-assisted mobile edge computing (MEC) has emerged as a valuable supplement to conventional MEC, offering unique advantages in temporary or emergency scenarios. However, the integration of UAVs into MEC introduces new challenges. First, the existing UAV-empowered MEC frameworks predominantly have not accounted for dependencies between the computing tasks. Second, the limited coverage area of UAVs and the sparse distribution of end devices result in a scarcity of training samples, hindering the effectiveness of data-driven approaches. To address these challenges, we introduce a novel UAV-assisted task offloading scheme designed to minimize the average task execution delay and energy consumption in vehicular networks. Initially, we craft a dependency-aware UAV-assisted MEC framework, where the task dependency and priority models are meticulously developed to illustrate the associations between the tasks. Subsequently, we devise an asynchronous federated deep reinforcement learning-based task offloading algorithm, incorporating an asynchronous federated optimization mechanism to enhance the data diversity, with a premise of ensuring data privacy. Our method has been rigorously tested using real traffic flow data and a directed acyclic graph task data set. Comparative experiments highlight the superiority of our framework, showcasing a substantial reduction in the average task delay and energy consumption.

Nowadays, the most common primary bone tumor is osteosarcoma, which mostly occurs in teenagers. A common diagnosis method is currently that doctors manually diagnose osteosarcoma in magnetic resonance imaging (MRI) images because it is nonradioactive and has no biological damage to brain tissue and more obvious performance in soft tissue components such as tumors, blood vessels, and muscles in MRI images. However, this method is labor-intensive and time-consuming work, and cannot guarantee the accuracy of the diagnostic results. Existing osteosarcoma MRI image segmentation methods either aim to model the global context to improve the inner consistency of objects, or multiscale feature fusion to refine the detail of objects along their boundaries, which all ignore the interaction between the body of the object and the object boundary. Therefore, this paper proposes a novel segmentation method for osteosarcoma MRI images based on DecoupleSegNet, which explores the relationship between body feature and edge feature. It can assist doctors in diagnosing osteosarcoma and improve their work efficiency. First, we warp the feature of MRI images through learning a flow field so we can make the object more consistent. We then make further work to optimize the resulting body feature and residual edge feature through explicitly sampling pixels from different parts under decoupled supervision. Through these steps, we finally obtain the final feature map with fine boundaries from the MRI image of osteosarcoma. We take a test by using more than 80,000 osteosarcoma MRI images obtained from three hospitals in China. We find that compared with existing osteosarcoma MRI image segmentation methods, our proposed method achieves 90.51 Intersection of Union % with few parameters on the test, outperforming other models. In the test, we prove that our proposed method has better accuracy and lower resource consumption.

Osteosarcoma is a malignant bone tumor commonly found in adolescents or children, with high incidence and poor prognosis. Magnetic resonance imaging (MRI), which is the more common diagnostic method for osteosarcoma, has a very large number of output images with sparse valid data and may not be easily observed due to brightness and contrast problems, which in turn makes manual diagnosis of osteosarcoma MRI images difficult and increases the rate of misdiagnosis. Current image segmentation models for osteosarcoma mostly focus on convolution, whose segmentation performance is limited due to the neglect of global features. In this paper, we propose an intelligent assisted diagnosis system for osteosarcoma, which can reduce the burden of doctors in diagnosing osteosarcoma from three aspects. First, we construct a classification-image enhancement module consisting of resnet18 and DeepUPE to remove redundant images and improve image clarity, which can facilitate doctors' observation. Then, we experimentally compare the performance of serial, parallel, and hybrid fusion transformer and convolution, and propose a Double U-shaped visual transformer with convolution (DUconViT) for automatic segmentation of osteosarcoma to assist doctors' diagnosis. This experiment utilizes more than 80,000 osteosarcoma MRI images from three hospitals in China. The results show that DUconViT can better segment osteosarcoma with DSC 2.6% and 1.8% higher than Unet and Unet++, respectively. Finally, we propose the pixel point quantification method to calculate the area of osteosarcoma, which provides more reference basis for doctors' diagnosis.

Osteosarcoma is the most common malignant osteosarcoma, and most developing countries face great challenges in the diagnosis due to the lack of medical resources. Magnetic resonance imaging (MRI) has always been an important tool for the detection of osteosarcoma, but it is a time-consuming and labor-intensive task for doctors to manually identify MRI images. It is highly subjective and prone to misdiagnosis. Existing computer-aided diagnosis methods of osteosarcoma MRI images focus only on accuracy, ignoring the lack of computing resources in developing countries. In addition, the large amount of redundant and noisy data generated during imaging should also be considered. To alleviate the inefficiency of osteosarcoma diagnosis faced by developing countries, this paper proposed an artificial intelligence multiprocessing scheme for pre-screening, noise reduction, and segmentation of osteosarcoma MRI images. For pre-screening, we propose the Slide Block Filter to remove useless images. Next, we introduced a fast non-local means algorithm using integral images to denoise noisy images. We then segmented the filtered and denoised MRI images using a U-shaped network (ETUNet) embedded with a transformer layer, which enhances the functionality and robustness of the traditional U-shaped architecture. Finally, we further optimized the segmented tumor boundaries using conditional random fields. This paper conducted experiments on more than 70,000 MRI images of osteosarcoma from three hospitals in China. The experimental results show that our proposed methods have good results and better performance in pre-screening, noise reduction, and segmentation.