A major challenge of the long measurement times in magnetic resonance imaging (MRI), an important medical imaging technology, is that patients may move during data acquisition. This leads to severe motion artifacts in the reconstructed images and volumes. In this paper, we propose MotionTTT a deep learning-based test-time-training (TTT) method for accurate motion estimation. The key idea is that a neural network trained for motion-free reconstruction has a small loss if there is no motion, thus optimizing over motion parameters passed through the reconstruction network enables accurate estimation of motion. The estimated motion parameters enable to correct for the motion and to reconstruct accurate motion-corrected images. Our method uses 2D reconstruction networks to estimate rigid motion in 3D, and constitutes the first deep learning based method for 3D rigid motion estimation towards 3D-motion-corrected MRI. We show that our method can provably reconstruct motion parameters for a simple signal and neural network model. We demonstrate the effectiveness of our method for both retrospectively simulated motion and prospectively collected real motion-corrupted data. Code is available at \url{https://github.com/MLI-lab/MRI_MotionTTT}.

Supervised training of deep neural networks on pairs of clean image and noisy measurement achieves state-of-the-art performance for many image reconstruction tasks, but such training pairs are difficult to collect. Self-supervised methods enable training based on noisy measurements only, without clean images. In this work, we investigate the cost of self-supervised training in terms of sample complexity for a class of self-supervised methods that enable the computation of unbiased estimates of gradients of the supervised loss, including noise2noise methods. We analytically show that a model trained with such self-supervised training is as good as the same model trained in a supervised fashion, but self-supervised training requires more examples than supervised training. We then study self-supervised denoising and accelerated MRI empirically and characterize the cost of self-supervised training in terms of the number of additional samples required, and find that the performance gap between self-supervised and supervised training vanishes as a function of the training examples, at a problem-dependent rate, as predicted by our theory.