Interpretability is essential in Whole Slide Image (WSI) analysis for computational pathology, where understanding model predictions helps build trust in AI-assisted diagnostics. While Integrated Gradients (IG) and related attribution methods have shown promise, applying them directly to WSIs introduces challenges due to their high-resolution nature. These methods capture model decision patterns but may overlook class-discriminative signals that are crucial for distinguishing between tumor subtypes. In this work, we introduce Contrastive Integrated Gradients (CIG), a novel attribution method that enhances interpretability by computing contrastive gradients in logit space. First, CIG highlights class-discriminative regions by comparing feature importance relative to a reference class, offering sharper differentiation between tumor and non-tumor areas. Second, CIG satisfies the axioms of integrated attribution, ensuring consistency and theoretical soundness. Third, we propose two attribution quality metrics, MIL-AIC and MIL-SIC, which measure how predictive information and model confidence evolve with access to salient regions, particularly under weak supervision. We validate CIG across three datasets spanning distinct cancer types: CAMELYON16 (breast cancer metastasis in lymph nodes), TCGA-RCC (renal cell carcinoma), and TCGA-Lung (lung cancer). Experimental results demonstrate that CIG yields more informative attributions both quantitatively, using MIL-AIC and MIL-SIC, and qualitatively, through visualizations that align closely with ground truth tumor regions, underscoring its potential for interpretable and trustworthy WSI-based diagnostics

Understanding radiologists' eye movement during Computed Tomography (CT) reading is crucial for developing effective interpretable computer-aided diagnosis systems. However, CT research in this area has been limited by the lack of publicly available eye-tracking datasets and the three-dimensional complexity of CT volumes. To address these challenges, we present the first publicly available eye gaze dataset on CT, called CT-ScanGaze. Then, we introduce CT-Searcher, a novel 3D scanpath predictor designed specifically to process CT volumes and generate radiologist-like 3D fixation sequences, overcoming the limitations of current scanpath predictors that only handle 2D inputs. Since deep learning models benefit from a pretraining step, we develop a pipeline that converts existing 2D gaze datasets into 3D gaze data to pretrain CT-Searcher. Through both qualitative and quantitative evaluations on CT-ScanGaze, we demonstrate the effectiveness of our approach and provide a comprehensive assessment framework for 3D scanpath prediction in medical imaging.

Medical eye-tracking data is an important information source for understanding how radiologists visually inter-pret medical images. This information not only improves the accuracy of deep learning models for X-ray analysis but also their interpretability, enhancing transparency in decision-making. However, the current eye-tracking data is dispersed, unprocessed, and ambiguous, making it difficult to derive meaningful insights. Therefore, there is a need to create a new dataset with more focus and purposeful eye-tracking data, improving its utility for diagnostic applications. In this work, we propose a refinement method inspired by the target-present visual search challenge: there is a specific finding and fixations are guided to locate it. After re-fining the existing eye-tracking datasets, we transform them into a curated visual search dataset, called Gazesearch. specifically for radiology findings, where each fixation sequence is purposefully aligned to the task of locating a particular finding. Subsequently, we introduce a scan path prediction baseline, called ChestSearch, specifically tailored to Gazesearch. Finally, we employ the newly introduced Gazesearch as a benchmark to evaluate the performance of current state-of-the-art methods, offering a comprehensive assessment for visual search in the medical imaging domain. Code is available at https://github.com/UARK-AICV/GazeSearch.

Detecting anomalies in videos is a fundamental challenge in machine learning, particularly for applications like disaster management. Leveraging satellite data, with its high frequency and wide coverage, proves invaluable for promptly identifying extreme events such as wildfires, cyclones, or floods. Geostationary satellites, providing data streams at frequent intervals, effectively create a continuous video feed of Earth from space. This study focuses on detecting anomalies, specifically wildfires and smoke, in these high-frequency satellite videos. In contrast to prior endeavors in anomaly detection within surveillance videos, this study introduces a system tailored for high-frequency satellite videos, placing particular emphasis on two anomalies. Unlike the majority of existing Convolution Neural Network-based methods for wildfire detection that rely on labeled images or videos, our unsupervised approach addresses the challenges posed by high-frequency satellite videos with a high intensity of clouds. These Convolution Neural Network-based methods can only identify fires once they have reached a certain size and are susceptible to false positives. We frame the challenge of wildfire detection as a general anomaly detection problem. Introducing an innovative unsupervised approach involving diffusion models, which are state-of-the-art generative models for anomaly detection in satellite videos, we adopt a “generating-to-detecting” strategy. Performance evaluation, measured through AUC-ROC, underscores the superior efficacy of the diffusion model over CNN and Generative Adversarial Networks-based methods in detecting anomalies in these high-frequency satellite videos characterized by a high intensity of clouds. The dataset utilized can be accessed at this location.