GPUs are essential to accelerating the latency-sensitive deep neural network (DNN) inference workloads in cloud datacenters. To fully utilize GPU resources,spatial sharingof GPUs among co-located DNN inference workloads becomes increasingly compelling. However, GPU sharing inevitably bringssevere performance interferenceamong co-located inference workloads, as motivated by an empirical measurement study of DNN inference on EC2 GPU instances. While existing works on guaranteeing inference performance service level objectives (SLOs) focus on eithertemporal sharingof GPUs orreactiveGPU resource scaling and inference migration techniques, how toproactivelymitigate such severe performance interference has received comparatively little attention. In this paper, we proposeiGniter, aninterference-awareGPU resource provisioning framework for cost-efficiently achieving predictable DNN inference in the cloud.iGniteris comprised of two key components: (1) alightweightDNN inference performance model, which leverages the system and workload metrics that are practically accessible to capture the performance interference; (2) Acost-efficientGPU resource provisioning strategy thatjointlyoptimizes the GPU resource allocation and adaptive batching based on our inference performance model, with the aim of achieving predictable performance of DNN inference workloads. We implement a prototype ofiGniterbased on the NVIDIA Triton inference server hosted on EC2 GPU instances. Extensive prototype experiments on four representative DNN models and datasets demonstrate thatiGnitercan guarantee the performance SLOs of DNN inference workloads with practically acceptable runtime overhead, while saving the monetary cost by up to$25\%$in comparison to the state-of-the-art GPU resource provisioning strategies.