This study proposes a spatial multiplexing wireless communication method based on coding metasurfaces, achieving efficient electromagnetic wave manipulation through optimized coding matrices to enable independent information transmission in different directions. By employing the weighting theorem, we optimize the reflection characteristics of the metasurface, suppressing sidelobe gain and enhancing the gain difference between the main and sidelobes. This improves beam directionality and reduces energy leakage in non-target directions. In the experiment, we constructed a dual-channel direct digital transmission system, where an FPGA dynamically modulates the coding metasurface to generate specific reflected beams based on input data, enabling independent transmission of a 6.1 GHz carrier signal in two asymmetric directions. Experimental results show that, with Chebyshev-weighted optimized coding sequences, the gain difference between the main lobe and the strongest sidelobe increased by 4.99 dB, 1.5 dB, and 7.33 dB at three positive angles (+18°, +28°, and +45°), and by 4.94 dB, 4.03 dB, and 4.22 dB at three negative angles (−15°, −35°, and −40°), respectively. Furthermore, a wireless communication system was constructed based on the metasurface, enabling simultaneous transmission of digital information at two asymmetric angles, −15° and +18°. The proposed spatial multiplexing strategy can be further extended to multi-channel wireless transmission. This study verifies the feasibility of using metasurfaces to manipulate communication signals, providing a foundational reference for future expansion and applications in complex channel environments.