Abstract Motivation: Meta-analysis of large gene expression datasets obtained from public repositories requires consistently annotated data. Curation of such experiments, however, is an expert activity which involves repetitive manipulation of text. Existing tools for automated curation are few, which bottleneck the analysis pipeline. Results: We present MageComet, a web application for biologists and annotators that facilitates the re-annotation of gene expression experiments in MAGE-TAB format. It incorporates data mining, automatic annotation, use of ontologies and data validation to improve the consistency and quality of experimental meta-data from the ArrayExpress Repository. Availability and implementation: Source and tutorials for MageComet are openly available at goo.gl/8LQPR under the GNU GPL v3 licenses. An implementation can be found at goo.gl/IdCuA Contact: [email protected] or [email protected]

This paper discusses the architecture, protocol, analysis, and experimentation of optical packet switching routers incorporating optical-label switching (OLS) technologies and electronic edge routers with traffic shaping capabilities. The core optical router incorporates all-optical switching with contention resolution in wavelength, time, and space domains. It is also capable of accommodating traffic of any protocol and format, and supports packet, flow, burst, and circuit traffic. The edge router is designed to achieve traffic shaping with consideration for quality of service and priority based class-of-service. Simulation results show packet loss rates below 0.3% at load 0.7 and jitter values below 18 μs. The traffic shaping reduces the packet loss rate by a factor of ∼5 while adding negligible additional latency. The OLS core routers and the electronic edge routers are constructed including the field-programmable-gate-arrays incorporating the wavelength-aware forwarding and contention resolution algorithms. The experiment shows optical-label-based packet switching with a packet loss rate near 0.2%.