Electronic health records (EHR) aggregate extensive data critical for advancing patient care and refining intervention strategies. EHR data is essential for epidemiological study, more commonly referred to as cohort study, where patients with shared characteristics or similar diseases are analyzed over time. Unfortunately, existing studies on cohort modeling are limited, struggling to derive fine-grained cohorts or effectively utilize cohort information, which hinders their ability to uncover intrinsic relationships between cohorts. To this end, we propose NeuralCohort, a cohort-aware neural representation learning method that precisely segments patients into finer-grained cohorts via an innovative cohort contextualization mechanism and captures both intra- and inter-cohort information using a Biscale Cohort Learning Module. Designed as a plug-in, NeuralCohort integrates seamlessly with existing backbone models, enhancing their cohort analysis capabilities by infusing deep cohort insights into the representation learning processes. The effectiveness and generalizability of NeuralCohort are validated across extensive real-world EHR datasets. Experimental results demonstrate that NeuralCohort consistently improves the performance of various backbone models, achieving up to an 8.1% increase in AUROC.

Relational database management systems (RDBMS) are widely used for the storage of structured data. To derive insights beyond statistical aggregation, we typically have to extract specific subdatasets from the database using conventional database operations, and then apply deep neural networks (DNN) training and inference on these subdatasets in a separate analytics system. The process can be prohibitively expensive, especially when there are various subdatasets extracted for different analytical purposes. This calls for efficient in-database support of advanced analytical methods. In this paper, we introduce LEADS, a novel SQL-aware dynamic model slicing technique to customize models for specified SQL queries. LEADS improves the predictive modeling of structured data via the mixture of experts (MoE) and maintains efficiency by a SQL-aware gating network. At the core of LEADS is the construction of a general model with multiple expert sub-models trained over the database. The MoE scales up the modeling capacity, enhances effectiveness, and preserves efficiency by activating necessary experts via the SQL-aware gating network during inference. To support in-database analytics, we build an inference extension that integrates LEADS onto PostgreSQL. Our extensive experiments on real-world datasets demonstrate that LEADS consistently outperforms the baseline models, and the in-database inference extension delivers a considerable reduction in inference latency compared to traditional solutions.

Conventional multi-label classification (MLC) methods assume that all samples are fully labeled and identically distributed. Unfortunately, this assumption is unrealistic in large-scale MLC data that has long-tailed (LT) distribution and partial labels (PL). To address the problem, we introduce a novel task, Partial labeling and Long-Tailed Multi-Label Classification (PLT-MLC), to jointly consider the above two imperfect learning environments. Not surprisingly, we find that most LT-MLC and PL-MLC approaches fail to solve the PLT-MLC, resulting in significant performance degradation on the two proposed PLT-MLC benchmarks. Therefore, we propose an end-to-end learning framework: COrrection → ModificatIon → balanCe, abbreviated as COMIC. Our bootstrapping philosophy is to simultaneously correct the missing labels (Correction) with convinced prediction confidence over a class-aware threshold and to learn from these recall labels during training. We next propose a novel multi-focal modifier loss that simultaneously addresses head-tail imbalance and positive-negative imbalance to adaptively modify the attention to different samples (Modification) under the LT class distribution. In addition, we develop a balanced training strategy by distilling the model’s learning effect from head and tail samples, and thus design a balanced classifier (Balance) conditioned on the head and tail learning effect to maintain stable performance for all samples. Our experimental study shows that the proposed COMIC significantly outperforms general MLC, LT-MLC and PL-MLC methods in terms of effectiveness and robustness on our newly created PLT-MLC datasets. Codes and benchmarks are available on the link https://https://github.com/wannature/COMIC