Existing approaches usually perform spatiotemporal representation in the spatial and temporal dimensions, respectively, which isolates the spatial and temporal natures of the target and leads to sub-optimal embeddings. Neuroscience research has shown that the mammalian brain entorhinal-hippocampal system provides efficient graph representations for general knowledge. Moreover, entorhinal grid cells present concise spatial representations, while hippocampal place cells represent perception conjunctions effectively. Thus, the entorhinal-hippocampal system provides a novel angle for spatiotemporal representation, which inspires us to propose the SpatioTemporal aware Embedding framework (STE) and apply it to POIs (STEP). STEP considers two types of POI-specific representations: sequential representation and spatiotemporal conjunctive representation, learned using sparse unlabeled data based on the proposed graph-building policies. Notably, STEP jointly represents the spatiotemporal natures of POIs using both observations and contextual information from integrated spatiotemporal dimensions by constructing a spatiotemporal context graph. Furthermore, we introduce a successive POI recommendation method using STEP, which achieves state-of-the-art performance on two benchmarks. In addition, we demonstrate the excellent performance of the STE representation approach in other spatiotemporal representation-centered tasks through a case study of the traffic flow prediction problem. Therefore, this work provides a novel solution to spatiotemporal representation and paves a new way for spatiotemporal modeling-related tasks.

Developing computational models of neural response is crucial for understanding sensory processing and neural computations. Current state-of-the-art neural network methods use temporal filters to handle temporal dependencies, resulting in an **unrealistic and inflexible processing paradigm**. Meanwhile, these methods target **trial-averaged firing rates** and fail to capture important features in spike trains. This work presents the temporal conditioning spiking latent variable models (***TeCoS-LVM***) to simulate the neural response to natural visual stimuli. We use spiking neurons to produce spike outputs that directly match the recorded trains. This approach helps to avoid losing information embedded in the original spike trains. We exclude the temporal dimension from the model parameter space and introduce a temporal conditioning operation to allow the model to adaptively explore and exploit temporal dependencies in stimuli sequences in a **natural paradigm**. We show that TeCoS-LVM models can produce more realistic spike activities and accurately fit spike statistics than powerful alternatives. Additionally, learned TeCoS-LVM models can generalize well to longer time scales. Overall, while remaining computationally tractable, our model effectively captures key features of neural coding systems. It thus provides a useful tool for building accurate predictive computational accounts for various sensory perception circuits.