Quantum computing has potential to provide exponential speedups over classical computing for many important applications. However, today's quantum computers are in their early stages, and hardware quality issues hinder the scale of program execution. Benchmarking and simulation of quantum circuits on classical computers is therefore essential to advance the understanding of how quantum computers and programs operate, enabling both algorithm discovery that leads to high-impact quantum computation and engineering improvements that deliver to more powerful quantum systems. Unfortunately, the nature of quantum information causes simulation complexity to scale exponentially with problem size.