We provide a method for compiling approximate multicontrolled single qubit gates into quantum circuits. Without ancilla qubits, the total number of elementary gates to decompose an n-qubit multicontrolled gate is proportional to 32n elementary operations. The proposed decomposition depends on an optimization technique that minimizes the CNOT gate count for multitarget and multicontrolled CNOT and SU(2) gates. We also provide an approximate decomposition with ancilla qubits with lower-circuit complexity. Computational experiments show the reduction of CNOT gates when multicontrolled U(2) gates are applied. As multicontrolled single-qubit gates serve as fundamental components of quantum algorithms, the proposed decomposition offers a comprehensive solution that can significantly decrease the count of elementary operations employed in quantum computing applications.