The synthesis of computed tomography images can supplement electron density information and eliminate MR-CT image registration errors. Consequently, an increasing number of MR-to-CT image translation approaches are being proposed for MR-only radiotherapy planning. However, due to substantial anatomical differences between various regions, traditional approaches often require each model to undergo independent development and use. In this paper, we propose a unified model driven by prompts that dynamically adapt to the different anatomical regions and generates CT images with high structural consistency. Specifically, it utilizes a region-specific attention mechanism, including a region-aware vector and a dynamic gating factor, to achieve MRI-to-CT image translation for multiple anatomical regions. Qualitative and quantitative results on three datasets of anatomical parts demonstrate that our models generate clearer and more anatomically detailed CT images than other state-of-the-art translation models. The results of the dosimetric analysis also indicate that our proposed model generates images with dose distributions more closely aligned to those of the real CT images. Thus, the proposed model demonstrates promising potential for enabling MR-only radiotherapy across multiple anatomical regions. we have released the source code for our RSAM model. The repository is accessible to the public at: https://github.com/yhyumi123/RSAM.

Modelling disease progression in precision medicine requires capturing complex spatio-temporal dynamics while preserving anatomical integrity. Existing methods often struggle with longitudinal dependencies and structural consistency in progressive disorders. To address these limitations, we introduce MambaControl, a novel framework that integrates selective state-space modelling with diffusion processes for high-fidelity prediction of medical image trajectories. To better capture subtle structural changes over time while maintaining anatomical consistency, MambaControl combines Mamba-Based long-range modelling with graph- guided anatomical control to more effectively represent anatomical correlations. Furthermore, we introduce Fourier-Enhanced spectral graph representations to capture spatial coherence and multiscale detail, enabling MambaControl to achieve state-of-the-art performance in Alzheimer’s disease prediction. Quantitative and regional evaluations demonstrate improved progression prediction quality and anatomical fidelity, highlighting its potential for personalised prognosis and clinical decision support.