Knowledge Distillation (KD) serves as an effective approach to addressing heterogeneity issues in Federated Learning (FL), leveraging additional datasets to align local and global models better. There are two primary distillation paradigms: feature-based distillation, which utilizes intermediate-layer features of the network, and logit-based distillation, which employs the final layer's logit outputs. However, existing studies often select distillation methods based on intuitive and empirical evidence when facing different heterogeneous settings, neglecting the intrinsic relationship between distillation paradigms and heterogeneity. This oversight may result in suboptimal federated knowledge distillation performance under heterogeneous conditions. In this paper, we propose the Consolidated Distillation for Heterogeneous Federated Learning - FedCD that balances knowledge representations from both feature-based and logit-based distillation to enhance performance. Specifically, to address the misalignment between knowledge conveyed by features and logits, we aggregate features from different layers via cross-layer attention to preserve semantic knowledge, followed by distribution modeling using Gaussian Mixture Models. This process strengthens knowledge distillation by constraining the transformation of different network layers' features under a consolidated distribution, thereby mitigating impacts from both data and model heterogeneity. Extensive experiments demonstrate that FedCD outperforms state-of-the-art methods by over 10.72% and validate the effectiveness of our approach.

Graph Neural Networks (GNNs) have been widely used for graph analysis. Federated Graph Learning (FGL) is an emerging learning framework to collaboratively train graph data from various clients. Although FGL allows client data to remain localized, a malicious server can still steal client private data information through uploaded gradient. In this paper, we for the first time propose label distribution attacks (LDAs11The term “LDA” here is different from other machine learning terms like Latent Dirichlet Allocation.) on FGL that aim to infer the label distributions of the client-side data. Firstly, we observe that the effectiveness of LDA is closely related to the variance of node embeddings in GNNs. Next, we analyze the relation between them and propose a new attack named ECLDA, which significantly improves the attack effectiveness by compressing node embeddings. Then, extensive experiments on node classification and link prediction tasks across six widely used graph datasets show that EC-LDA outperforms the SOTA LDAs. Specifically, EC-LDA can achieve the Cos-sim as high as 1.0 under almost all cases. Finally, we explore the robustness of EC-LDA under differential privacy protection and discuss the potential effective defense methods to EC-LDA. Our code is available at https://github.com/cheng-t/EC-LDA.

The swift advancement of single-cell RNA sequencing (scRNA-seq) technologies enables the investigation of cellular-level tissue heterogeneity. Cell annotation significantly contributes to the extensive downstream analysis of scRNA-seq data. However, The analysis of scRNA-seq for biological inference presents challenges owing to its intricate and indeterminate data distribution, characterized by a substantial volume and a high frequency of dropout events. Furthermore, the quality of training samples varies greatly, and the performance of the popular scRNA-seq data clustering solution GNN could be harmed by two types of low-quality training nodes: 1) nodes on the boundary; 2) nodes that contribute little additional information to the graph. To address these problems, we propose a single-cell curriculum learning-based deep graph embedding clustering (scCLG). We first propose a Chebyshev graph convolutional autoencoder with multi-criteria (ChebAE) that combines three optimization objectives, including topology reconstruction loss of cell graphs, zero-inflated negative binomial (ZINB) loss, and clustering loss, to learn cell-cell topology representation. Meanwhile, we employ a selective training strategy to train GNN based on the features and entropy of nodes and prune the difficult nodes based on the difficulty scores to keep the high-quality graph. Empirical results on a variety of gene expression datasets show that our model outperforms state-of-the-art methods. The code of scCLG will be made publicly available at https://github.com/LFD-byte/scCLG.