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Lieke Michielsen

dblp:367/0041 · DBLP profile ↗
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1ranked-venue papers
0as first author
1since 2021 · last 2023
0000-0003-4615-1309ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 3 heaviest of 3, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › single-cell analysis › cell type annotation
cell type classification
0.712023
Cell type matching across species using protein embeddings and transfer learning · Bioinform. 2023
Bioinformatics and computational biology › comparative genomics
cross-species sequence comparison
0.712023
Cell type matching across species using protein embeddings and transfer learning · Bioinform. 2023
Bioinformatics and computational biology
single-cell analysis
0.712023
Cell type matching across species using protein embeddings and transfer learning · Bioinform. 2023

Methods — techniques the papers use, named apart from their topics

transfer learning · 0.7protein embedding · 0.7neural network · 0.7natural language processing · 0.7
YearPublicationVenuePosition
2023 Cell type matching across species using protein embeddings and transfer learning
abstract
MOTIVATION: Knowing the relation between cell types is crucial for translating experimental results from mice to humans. Establishing cell type matches, however, is hindered by the biological differences between the species. A substantial amount of evolutionary information between genes that could be used to align the species is discarded by most of the current methods since they only use one-to-one orthologous genes. Some methods try to retain the information by explicitly including the relation between genes, however, not without caveats. RESULTS: In this work, we present a model to transfer and align cell types in cross-species analysis (TACTiCS). First, TACTiCS uses a natural language processing model to match genes using their protein sequences. Next, TACTiCS employs a neural network to classify cell types within a species. Afterward, TACTiCS uses transfer learning to propagate cell type labels between species. We applied TACTiCS on scRNA-seq data of the primary motor cortex of human, mouse, and marmoset. Our model can accurately match and align cell types on these datasets. Moreover, our model outperforms Seurat and the state-of-the-art method SAMap. Finally, we show that our gene matching method results in better cell type matches than BLAST in our model. AVAILABILITY AND IMPLEMENTATION: The implementation is available on GitHub (https://github.com/kbiharie/TACTiCS). The preprocessed datasets and trained models can be downloaded from Zenodo (https://doi.org/10.5281/zenodo.7582460).
Kirti Biharie, Lieke Michielsen, Marcel J. T. Reinders, Ahmed Mahfouz
Bioinform.2